Multimodal and multifunctional stealth polymer nanospheres for sustained drug deliveryElectronic supplementary information (ESI) available: TEM of magnetite nanoparticles, magnetic characterisation by SQUID, relaxometry plots. See DOI: 10.1039/c2nj40016b

Multimodal and multifunctional stealth polymer nanospheres for sustained drug deliveryElectronic supplementary information (ESI) available: TEM of magnetite nanoparticles, magnetic characterisation by SQUID, relaxometry plots. See DOI: 10.1039/c2nj40016b

We report the preparation of fluorescent and magnetic PMMA nanospheres, and a corresponding PEGylated 'stealth' analogue prepared using a block copolymer. The nanospheres contain encapsulated magnetite nanoparticles and fluorescent BODIPY dyes, including a new such dye with pH-sensitive fl...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Evans, Cameron W, Latter, Melissa J, Ho, Diwei, Peerzade, Saquib Ahmed M. A, Clemons, Tristan D, Fitzgerald, Melinda, Dunlop, Sarah A, Iyer, K. Swaminathan
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 1462
container_issue 7
container_start_page 1457
container_title
container_volume 36
creator Evans, Cameron W
Latter, Melissa J
Ho, Diwei
Peerzade, Saquib Ahmed M. A
Clemons, Tristan D
Fitzgerald, Melinda
Dunlop, Sarah A
Iyer, K. Swaminathan
description We report the preparation of fluorescent and magnetic PMMA nanospheres, and a corresponding PEGylated 'stealth' analogue prepared using a block copolymer. The nanospheres contain encapsulated magnetite nanoparticles and fluorescent BODIPY dyes, including a new such dye with pH-sensitive fluorescent emission. The new dye could potentially be used as an indicator of the immediate physiological environment. The nanospheres were non-toxic at up to 500 μg ml −1 in PC12 cells. Lomerizine, a lipophilic calcium channel blocker, was also encapsulated in the nanospheres and displayed sustained, pH-dependent release characteristics. The nanospheres may be of use to release lomerizine and other water-insoluble drugs at central nervous system injury sites. Multimodal stealth PMMA nanospheres for sustained and pH-dependent drug delivery.
doi_str_mv 10.1039/c2nj40016b
format Article
fullrecord <record><control><sourceid>rsc</sourceid><recordid>TN_cdi_rsc_primary_c2nj40016b</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>c2nj40016b</sourcerecordid><originalsourceid>FETCH-rsc_primary_c2nj40016b3</originalsourceid><addsrcrecordid>eNqFUE1Lw0AQXUTBWr14F8abQluzTYy0VxuxhyLSei7TzaTdsl_sbor582LqBx4EPc3Me2_eG4axc54MeJKObsTQbLMk4fnqgHV4mo_6o2HOD9ueZ1k_uc3yY3YSwraV8Lucd9jbrFZRaluiAjQl6P1Y1UZEaU2LhUio4gacVY0mDwaNDW5DngJU1kOoQ0RpqITS12soSckd-aZQJKK3RopW4ZwiTSaib0Cadkvj3h2uivn0GnCHUuFK0RgWxQxsBRrXhqKM9JHm0EcpFIXeNyFAbNCjiORl-LRaNTB_fplOeuBJ4avVFNswp2wMA5gTweRpOobfXzplRxWqQGdftcsuHorF_WPfB7F0Xur25uWPPO2yy7_4pSur9D-Pdz6Hi0s</addsrcrecordid><sourcetype>Enrichment Source</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Multimodal and multifunctional stealth polymer nanospheres for sustained drug deliveryElectronic supplementary information (ESI) available: TEM of magnetite nanoparticles, magnetic characterisation by SQUID, relaxometry plots. See DOI: 10.1039/c2nj40016b</title><source>Royal Society Of Chemistry Journals 2008-</source><source>Alma/SFX Local Collection</source><creator>Evans, Cameron W ; Latter, Melissa J ; Ho, Diwei ; Peerzade, Saquib Ahmed M. A ; Clemons, Tristan D ; Fitzgerald, Melinda ; Dunlop, Sarah A ; Iyer, K. Swaminathan</creator><creatorcontrib>Evans, Cameron W ; Latter, Melissa J ; Ho, Diwei ; Peerzade, Saquib Ahmed M. A ; Clemons, Tristan D ; Fitzgerald, Melinda ; Dunlop, Sarah A ; Iyer, K. Swaminathan</creatorcontrib><description>We report the preparation of fluorescent and magnetic PMMA nanospheres, and a corresponding PEGylated 'stealth' analogue prepared using a block copolymer. The nanospheres contain encapsulated magnetite nanoparticles and fluorescent BODIPY dyes, including a new such dye with pH-sensitive fluorescent emission. The new dye could potentially be used as an indicator of the immediate physiological environment. The nanospheres were non-toxic at up to 500 μg ml −1 in PC12 cells. Lomerizine, a lipophilic calcium channel blocker, was also encapsulated in the nanospheres and displayed sustained, pH-dependent release characteristics. The nanospheres may be of use to release lomerizine and other water-insoluble drugs at central nervous system injury sites. Multimodal stealth PMMA nanospheres for sustained and pH-dependent drug delivery.</description><identifier>ISSN: 1144-0546</identifier><identifier>EISSN: 1369-9261</identifier><identifier>DOI: 10.1039/c2nj40016b</identifier><language>eng</language><creationdate>2012-07</creationdate><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Evans, Cameron W</creatorcontrib><creatorcontrib>Latter, Melissa J</creatorcontrib><creatorcontrib>Ho, Diwei</creatorcontrib><creatorcontrib>Peerzade, Saquib Ahmed M. A</creatorcontrib><creatorcontrib>Clemons, Tristan D</creatorcontrib><creatorcontrib>Fitzgerald, Melinda</creatorcontrib><creatorcontrib>Dunlop, Sarah A</creatorcontrib><creatorcontrib>Iyer, K. Swaminathan</creatorcontrib><title>Multimodal and multifunctional stealth polymer nanospheres for sustained drug deliveryElectronic supplementary information (ESI) available: TEM of magnetite nanoparticles, magnetic characterisation by SQUID, relaxometry plots. See DOI: 10.1039/c2nj40016b</title><description>We report the preparation of fluorescent and magnetic PMMA nanospheres, and a corresponding PEGylated 'stealth' analogue prepared using a block copolymer. The nanospheres contain encapsulated magnetite nanoparticles and fluorescent BODIPY dyes, including a new such dye with pH-sensitive fluorescent emission. The new dye could potentially be used as an indicator of the immediate physiological environment. The nanospheres were non-toxic at up to 500 μg ml −1 in PC12 cells. Lomerizine, a lipophilic calcium channel blocker, was also encapsulated in the nanospheres and displayed sustained, pH-dependent release characteristics. The nanospheres may be of use to release lomerizine and other water-insoluble drugs at central nervous system injury sites. Multimodal stealth PMMA nanospheres for sustained and pH-dependent drug delivery.</description><issn>1144-0546</issn><issn>1369-9261</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNqFUE1Lw0AQXUTBWr14F8abQluzTYy0VxuxhyLSei7TzaTdsl_sbor582LqBx4EPc3Me2_eG4axc54MeJKObsTQbLMk4fnqgHV4mo_6o2HOD9ueZ1k_uc3yY3YSwraV8Lucd9jbrFZRaluiAjQl6P1Y1UZEaU2LhUio4gacVY0mDwaNDW5DngJU1kOoQ0RpqITS12soSckd-aZQJKK3RopW4ZwiTSaib0Cadkvj3h2uivn0GnCHUuFK0RgWxQxsBRrXhqKM9JHm0EcpFIXeNyFAbNCjiORl-LRaNTB_fplOeuBJ4avVFNswp2wMA5gTweRpOobfXzplRxWqQGdftcsuHorF_WPfB7F0Xur25uWPPO2yy7_4pSur9D-Pdz6Hi0s</recordid><startdate>20120701</startdate><enddate>20120701</enddate><creator>Evans, Cameron W</creator><creator>Latter, Melissa J</creator><creator>Ho, Diwei</creator><creator>Peerzade, Saquib Ahmed M. A</creator><creator>Clemons, Tristan D</creator><creator>Fitzgerald, Melinda</creator><creator>Dunlop, Sarah A</creator><creator>Iyer, K. Swaminathan</creator><scope/></search><sort><creationdate>20120701</creationdate><title>Multimodal and multifunctional stealth polymer nanospheres for sustained drug deliveryElectronic supplementary information (ESI) available: TEM of magnetite nanoparticles, magnetic characterisation by SQUID, relaxometry plots. See DOI: 10.1039/c2nj40016b</title><author>Evans, Cameron W ; Latter, Melissa J ; Ho, Diwei ; Peerzade, Saquib Ahmed M. A ; Clemons, Tristan D ; Fitzgerald, Melinda ; Dunlop, Sarah A ; Iyer, K. Swaminathan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-rsc_primary_c2nj40016b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Evans, Cameron W</creatorcontrib><creatorcontrib>Latter, Melissa J</creatorcontrib><creatorcontrib>Ho, Diwei</creatorcontrib><creatorcontrib>Peerzade, Saquib Ahmed M. A</creatorcontrib><creatorcontrib>Clemons, Tristan D</creatorcontrib><creatorcontrib>Fitzgerald, Melinda</creatorcontrib><creatorcontrib>Dunlop, Sarah A</creatorcontrib><creatorcontrib>Iyer, K. Swaminathan</creatorcontrib></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Evans, Cameron W</au><au>Latter, Melissa J</au><au>Ho, Diwei</au><au>Peerzade, Saquib Ahmed M. A</au><au>Clemons, Tristan D</au><au>Fitzgerald, Melinda</au><au>Dunlop, Sarah A</au><au>Iyer, K. Swaminathan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multimodal and multifunctional stealth polymer nanospheres for sustained drug deliveryElectronic supplementary information (ESI) available: TEM of magnetite nanoparticles, magnetic characterisation by SQUID, relaxometry plots. See DOI: 10.1039/c2nj40016b</atitle><date>2012-07-01</date><risdate>2012</risdate><volume>36</volume><issue>7</issue><spage>1457</spage><epage>1462</epage><pages>1457-1462</pages><issn>1144-0546</issn><eissn>1369-9261</eissn><abstract>We report the preparation of fluorescent and magnetic PMMA nanospheres, and a corresponding PEGylated 'stealth' analogue prepared using a block copolymer. The nanospheres contain encapsulated magnetite nanoparticles and fluorescent BODIPY dyes, including a new such dye with pH-sensitive fluorescent emission. The new dye could potentially be used as an indicator of the immediate physiological environment. The nanospheres were non-toxic at up to 500 μg ml −1 in PC12 cells. Lomerizine, a lipophilic calcium channel blocker, was also encapsulated in the nanospheres and displayed sustained, pH-dependent release characteristics. The nanospheres may be of use to release lomerizine and other water-insoluble drugs at central nervous system injury sites. Multimodal stealth PMMA nanospheres for sustained and pH-dependent drug delivery.</abstract><doi>10.1039/c2nj40016b</doi><tpages>6</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1144-0546
ispartof
issn 1144-0546
1369-9261
language eng
recordid cdi_rsc_primary_c2nj40016b
source Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection
title Multimodal and multifunctional stealth polymer nanospheres for sustained drug deliveryElectronic supplementary information (ESI) available: TEM of magnetite nanoparticles, magnetic characterisation by SQUID, relaxometry plots. See DOI: 10.1039/c2nj40016b
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T08%3A26%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-rsc&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Multimodal%20and%20multifunctional%20stealth%20polymer%20nanospheres%20for%20sustained%20drug%20deliveryElectronic%20supplementary%20information%20(ESI)%20available:%20TEM%20of%20magnetite%20nanoparticles,%20magnetic%20characterisation%20by%20SQUID,%20relaxometry%20plots.%20See%20DOI:%2010.1039/c2nj40016b&rft.au=Evans,%20Cameron%20W&rft.date=2012-07-01&rft.volume=36&rft.issue=7&rft.spage=1457&rft.epage=1462&rft.pages=1457-1462&rft.issn=1144-0546&rft.eissn=1369-9261&rft_id=info:doi/10.1039/c2nj40016b&rft_dat=%3Crsc%3Ec2nj40016b%3C/rsc%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true