Small-molecule inhibitors of dimeric transcription factors: Antagonism of protein-protein and protein-DNA interactions

Transcription factors are DNA-binding proteins that - usually in combination with other proteins to form the pre-initiation complex (PIC) - regulate the transcription of specific DNA sequences (genes) into mRNA by controlling the recruitment of RNA polymerase II. Constitutive activation of transcrip...

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Veröffentlicht in:	MedChemComm 2012-05, Vol.3 (5), p.541-551
Hauptverfasser:	Yap, Jeremy L, Chauhan, Jay, Jung, Kwan-Young, Chen, Lijia, Prochownik, Edward V, Fletcher, Steven
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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