Cysteine and histidine shuffling: mixing and matching cysteine and histidine residues in zinc finger proteins to afford different folds and functionWe are grateful to the NSF (NSF CAREER Award # CHE-0747863) for support of this research

Zinc finger proteins utilize zinc for structural purposes: zinc binds to a combination of cysteine and histidine ligands in a tetrahedral coordination geometry facilitating protein folding and function. While much is known about the classical zinc finger proteins, which utilize a Cys 2 His 2 ligand...

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Hauptverfasser:	Michalek, Jamie L, Besold, Angelique N, Michel, Sarah L. J
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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