Copper(i) catalyzed asymmetric 1,2-addition of Grignard reagents to -methyl substituted ,-unsaturated ketonesThis article is part of the ChemComm Emerging Investigators 2012 themed issue.Electronic supplementary information (ESI) available. See DOI: 10.1039/c1cc16725a
The first catalytic enantioselective 1,2-addition of Grignard reagents to ketones is presented. This additive-free copper( i ) catalyzed 1,2-addition provides chiral allylic tertiary alcohols with an er of up to 98:2 and excellent yields due to the complete shift of overwhelming 1,4-selectivity of c...
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| creator | Madduri, Ashoka V. R Minnaard, Adriaan J Harutyunyan, Syuzanna R |
| description | The first catalytic enantioselective 1,2-addition of Grignard reagents to ketones is presented. This additive-free copper(
i
) catalyzed 1,2-addition provides chiral allylic tertiary alcohols with an er of up to 98:2 and excellent yields due to the complete shift of overwhelming 1,4-selectivity of copper(
i
)-catalysts towards 1,2-selectivity in the addition reaction to enones.
Copper-catalyzed 1,2-addition of Grignard reagents to enones has been achieved for the first time with high enantioselectivities and excellent yields. |
| doi_str_mv | 10.1039/c1cc16725a |
| format | Article |
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i
) catalyzed 1,2-addition provides chiral allylic tertiary alcohols with an er of up to 98:2 and excellent yields due to the complete shift of overwhelming 1,4-selectivity of copper(
i
)-catalysts towards 1,2-selectivity in the addition reaction to enones.
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i
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i
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i
)-catalysts towards 1,2-selectivity in the addition reaction to enones.
Copper-catalyzed 1,2-addition of Grignard reagents to enones has been achieved for the first time with high enantioselectivities and excellent yields.</abstract><doi>10.1039/c1cc16725a</doi><tpages>3</tpages></addata></record> |
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| title | Copper(i) catalyzed asymmetric 1,2-addition of Grignard reagents to -methyl substituted ,-unsaturated ketonesThis article is part of the ChemComm Emerging Investigators 2012 themed issue.Electronic supplementary information (ESI) available. See DOI: 10.1039/c1cc16725a |
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