Synthesis of cyclic adenosine 5′-diphosphate ribose analogues: a C2′ endo/syn "southern" ribose conformation underlies activity at the sea urchin cADPR receptorThis paper is part of an Organic & Biomolecular Chemistry web theme issue on chemical biology

Novel 8-substituted base and sugar-modified analogues of the Ca 2+ mobilizing second messenger cyclic adenosine 5′-diphosphate ribose (cADPR) were synthesized using a chemoenzymatic approach and evaluated for activity in sea urchin egg homogenate (SUH) and in Jurkat T-lymphocytes; conformational ana...

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Hauptverfasser:	Moreau, Christelle, Ashamu, Gloria A, Bailey, Victoria C, Galione, Antony, Guse, Andreas H, Potter, Barry V. L
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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