Synthesis of chiral β-aminoalcohol palladium complexes exhibiting cytotoxic propertiesCCDC reference numbers CCDC 767180 (3, PdCl2(norephedrine)2), 745869 (6, Pd(OAc)2(valinol)2), 745867 (11, PdCl2(prolinol)2), 745868 (13, Pd(prolinato)2). For crystallographic data in CIF or other electronic format see DOI: 10.1039/c0dt00328j

Synthesis of chiral β-aminoalcohol palladium complexes exhibiting cytotoxic propertiesCCDC reference numbers CCDC 767180 (3, PdCl2(norephedrine)2), 745869 (6, Pd(OAc)2(valinol)2), 745867 (11, PdCl2(prolinol)2), 745868 (13, Pd(prolinato)2). For crystallographic data in CIF or other electronic format see DOI: 10.1039/c0dt00328j

Original palladium complexes involving (−)-ephedrine, (−)-norephedrine, L-prolinol, L-valinol and L-isoleucinol have been rapidly prepared in neutral or basic medium and simply purified. They have been fully characterized by classical analytical methods and four of them were characterized by X-Ray a...

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Hauptverfasser: Accadbled, Fabien, Tinant, Bernard, Hénon, Eric, Carrez, Danièle, Croisy, Alain, Bouquillon, Sandrine
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Tinant, Bernard
Hénon, Eric
Carrez, Danièle
Croisy, Alain
Bouquillon, Sandrine
description Original palladium complexes involving (−)-ephedrine, (−)-norephedrine, L-prolinol, L-valinol and L-isoleucinol have been rapidly prepared in neutral or basic medium and simply purified. They have been fully characterized by classical analytical methods and four of them were characterized by X-Ray analysis. In parallel with the experimental work, HF-DFT(B3LYP/PCM) computations were performed to obtain additional structural information. Their antiproliferative properties have been evaluated and some complexes showed small activities especially towards HT29 human cancer cells. Original palladium complexes involving (−)-ephedrine, (−)-norephedrine, L-prolinol, L-valinol and L-isoleucinol have been rapidly prepared in neutral or basic medium and simply purified.
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title Synthesis of chiral β-aminoalcohol palladium complexes exhibiting cytotoxic propertiesCCDC reference numbers CCDC 767180 (3, PdCl2(norephedrine)2), 745869 (6, Pd(OAc)2(valinol)2), 745867 (11, PdCl2(prolinol)2), 745868 (13, Pd(prolinato)2). For crystallographic data in CIF or other electronic format see DOI: 10.1039/c0dt00328j
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