Osmium(vi) complexes as a new class of potential anti-cancer agentsElectronic supplementary information (ESI) available: Experimental section, Fig. S1: stability evaluation of 1; Fig. S2 and S3: UV-visible spectral change of 1 in the presence of GSH and 5′-GMP; Fig. S4: cytotoxic profiles of 1 towards cancerous cell lines; Fig. S5: antiproliferative effects of 1 and cisplatin in HeLa and HepG2 for 72 h; Fig. S6: cytotoxic profiles of 1 and cisplatin towards CCD-19Lu cells; Fig. S7: flow cytometr
A nitridoosmium( vi ) complex [Os VI (N)(sap)(OH 2 )Cl] (H 2 sap = N -salicylidene-2-aminophenol) displays prominent in vitro and in vivo anti-cancer properties, induces S- and G2/M-phase arrest and forms a stable adduct with dianionic 5′-guanosine monophosphate. A nitridoosmium( vi ) complex [Os VI...
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| creator | Ni, Wen-Xiu Man, Wai-Lun Cheung, Myra Ting-Wai Sun, Raymond Wai-Yin Shu, Yuan-Lan Lam, Yun-Wah Che, Chi-Ming Lau, Tai-Chu |
| description | A nitridoosmium(
vi
) complex [Os
VI
(N)(sap)(OH
2
)Cl] (H
2
sap =
N
-salicylidene-2-aminophenol) displays prominent
in vitro
and
in vivo
anti-cancer properties, induces S- and G2/M-phase arrest and forms a stable adduct with dianionic 5′-guanosine monophosphate.
A nitridoosmium(
vi
) complex [Os
VI
(N)(sap)(OH
2
)Cl] (H
2
sap =
N
-salicylidene-2-aminophenol) displays prominent
in vitro
and
in vivo
anti-cancer properties, induces S- and G2/M-phase arrest and forms a stable adduct with dianionic 5′-guanosine monophosphate. |
| doi_str_mv | 10.1039/c0cc04515b |
| format | Article |
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vi
) complex [Os
VI
(N)(sap)(OH
2
)Cl] (H
2
sap =
N
-salicylidene-2-aminophenol) displays prominent
in vitro
and
in vivo
anti-cancer properties, induces S- and G2/M-phase arrest and forms a stable adduct with dianionic 5′-guanosine monophosphate.
A nitridoosmium(
vi
) complex [Os
VI
(N)(sap)(OH
2
)Cl] (H
2
sap =
N
-salicylidene-2-aminophenol) displays prominent
in vitro
and
in vivo
anti-cancer properties, induces S- and G2/M-phase arrest and forms a stable adduct with dianionic 5′-guanosine monophosphate.</description><identifier>ISSN: 1359-7345</identifier><identifier>EISSN: 1364-548X</identifier><identifier>DOI: 10.1039/c0cc04515b</identifier><language>eng</language><creationdate>2011-02</creationdate><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids></links><search><creatorcontrib>Ni, Wen-Xiu</creatorcontrib><creatorcontrib>Man, Wai-Lun</creatorcontrib><creatorcontrib>Cheung, Myra Ting-Wai</creatorcontrib><creatorcontrib>Sun, Raymond Wai-Yin</creatorcontrib><creatorcontrib>Shu, Yuan-Lan</creatorcontrib><creatorcontrib>Lam, Yun-Wah</creatorcontrib><creatorcontrib>Che, Chi-Ming</creatorcontrib><creatorcontrib>Lau, Tai-Chu</creatorcontrib><title>Osmium(vi) complexes as a new class of potential anti-cancer agentsElectronic supplementary information (ESI) available: Experimental section, Fig. S1: stability evaluation of 1; Fig. S2 and S3: UV-visible spectral change of 1 in the presence of GSH and 5′-GMP; Fig. S4: cytotoxic profiles of 1 towards cancerous cell lines; Fig. S5: antiproliferative effects of 1 and cisplatin in HeLa and HepG2 for 72 h; Fig. S6: cytotoxic profiles of 1 and cisplatin towards CCD-19Lu cells; Fig. S7: flow cytometr</title><description>A nitridoosmium(
vi
) complex [Os
VI
(N)(sap)(OH
2
)Cl] (H
2
sap =
N
-salicylidene-2-aminophenol) displays prominent
in vitro
and
in vivo
anti-cancer properties, induces S- and G2/M-phase arrest and forms a stable adduct with dianionic 5′-guanosine monophosphate.
A nitridoosmium(
vi
) complex [Os
VI
(N)(sap)(OH
2
)Cl] (H
2
sap =
N
-salicylidene-2-aminophenol) displays prominent
in vitro
and
in vivo
anti-cancer properties, induces S- and G2/M-phase arrest and forms a stable adduct with dianionic 5′-guanosine monophosphate.</description><issn>1359-7345</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNqFksuO0zAUQAMCieGxYY902c1IZEiaZDoNy9JpkQaBVEDsKte9aY0c2_J10nbHN_FJfARrbtIWxAKwItm6j5PjRxQ9TZPLNMlGL2UiZZIXabG8G52l2VUeF_n153vduhjFwywvHkQPib4kPNLi-uzOj3dUq6Y-b9UFSFs7jTskEPyBwS1ILYjAVuBsQBOU0CB4iqUwEj2INQdpolEGb42SQI1jRM1R4fegTGV9LYKyBs4n8zcXIFqhtFhqLGGyc-hVX6qBmMBVL-BGrS9hnpZAQSyVVmEP2ArdHCAskr461gzYZAXzrISPn-JWkWIqkOtUGCg3wqyxb2ANCBsE55GQtbvgdD7r24vvX7_F07fvT9C8BLkPNtgdb8Z5WymNdKAEuxV-RXDYum14hVqDVgbp1F6U_fFwo1YVepZuEbCqWOpI6X4qFTnNOdOZzfBW9NEZuukA-MBgOIDNiXj1d6E_USe98fh1nI5um97ul9iwhErbbc-qMfjH0f1KaMInx_lR9Oxm8mE8iz3JheNr4etb_H5M2f_zz_-VX7hVlf0EUNHdXQ</recordid><startdate>20110201</startdate><enddate>20110201</enddate><creator>Ni, Wen-Xiu</creator><creator>Man, Wai-Lun</creator><creator>Cheung, Myra Ting-Wai</creator><creator>Sun, Raymond Wai-Yin</creator><creator>Shu, Yuan-Lan</creator><creator>Lam, Yun-Wah</creator><creator>Che, Chi-Ming</creator><creator>Lau, Tai-Chu</creator><scope/></search><sort><creationdate>20110201</creationdate><title>Osmium(vi) complexes as a new class of potential anti-cancer agentsElectronic supplementary information (ESI) available: Experimental section, Fig. S1: stability evaluation of 1; Fig. S2 and S3: UV-visible spectral change of 1 in the presence of GSH and 5′-GMP; Fig. S4: cytotoxic profiles of 1 towards cancerous cell lines; Fig. S5: antiproliferative effects of 1 and cisplatin in HeLa and HepG2 for 72 h; Fig. S6: cytotoxic profiles of 1 and cisplatin towards CCD-19Lu cells; Fig. S7: flow cytometr</title><author>Ni, Wen-Xiu ; Man, Wai-Lun ; Cheung, Myra Ting-Wai ; Sun, Raymond Wai-Yin ; Shu, Yuan-Lan ; Lam, Yun-Wah ; Che, Chi-Ming ; Lau, Tai-Chu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-rsc_primary_c0cc04515b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ni, Wen-Xiu</creatorcontrib><creatorcontrib>Man, Wai-Lun</creatorcontrib><creatorcontrib>Cheung, Myra Ting-Wai</creatorcontrib><creatorcontrib>Sun, Raymond Wai-Yin</creatorcontrib><creatorcontrib>Shu, Yuan-Lan</creatorcontrib><creatorcontrib>Lam, Yun-Wah</creatorcontrib><creatorcontrib>Che, Chi-Ming</creatorcontrib><creatorcontrib>Lau, Tai-Chu</creatorcontrib></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ni, Wen-Xiu</au><au>Man, Wai-Lun</au><au>Cheung, Myra Ting-Wai</au><au>Sun, Raymond Wai-Yin</au><au>Shu, Yuan-Lan</au><au>Lam, Yun-Wah</au><au>Che, Chi-Ming</au><au>Lau, Tai-Chu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Osmium(vi) complexes as a new class of potential anti-cancer agentsElectronic supplementary information (ESI) available: Experimental section, Fig. S1: stability evaluation of 1; Fig. S2 and S3: UV-visible spectral change of 1 in the presence of GSH and 5′-GMP; Fig. S4: cytotoxic profiles of 1 towards cancerous cell lines; Fig. S5: antiproliferative effects of 1 and cisplatin in HeLa and HepG2 for 72 h; Fig. S6: cytotoxic profiles of 1 and cisplatin towards CCD-19Lu cells; Fig. S7: flow cytometr</atitle><date>2011-02-01</date><risdate>2011</risdate><volume>47</volume><issue>7</issue><spage>214</spage><epage>2142</epage><pages>214-2142</pages><issn>1359-7345</issn><eissn>1364-548X</eissn><abstract>A nitridoosmium(
vi
) complex [Os
VI
(N)(sap)(OH
2
)Cl] (H
2
sap =
N
-salicylidene-2-aminophenol) displays prominent
in vitro
and
in vivo
anti-cancer properties, induces S- and G2/M-phase arrest and forms a stable adduct with dianionic 5′-guanosine monophosphate.
A nitridoosmium(
vi
) complex [Os
VI
(N)(sap)(OH
2
)Cl] (H
2
sap =
N
-salicylidene-2-aminophenol) displays prominent
in vitro
and
in vivo
anti-cancer properties, induces S- and G2/M-phase arrest and forms a stable adduct with dianionic 5′-guanosine monophosphate.</abstract><doi>10.1039/c0cc04515b</doi><tpages>3</tpages></addata></record> |
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| language | eng |
| recordid | cdi_rsc_primary_c0cc04515b |
| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| title | Osmium(vi) complexes as a new class of potential anti-cancer agentsElectronic supplementary information (ESI) available: Experimental section, Fig. S1: stability evaluation of 1; Fig. S2 and S3: UV-visible spectral change of 1 in the presence of GSH and 5′-GMP; Fig. S4: cytotoxic profiles of 1 towards cancerous cell lines; Fig. S5: antiproliferative effects of 1 and cisplatin in HeLa and HepG2 for 72 h; Fig. S6: cytotoxic profiles of 1 and cisplatin towards CCD-19Lu cells; Fig. S7: flow cytometr |
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