Osmium(vi) complexes as a new class of potential anti-cancer agentsElectronic supplementary information (ESI) available: Experimental section, Fig. S1: stability evaluation of 1; Fig. S2 and S3: UV-visible spectral change of 1 in the presence of GSH and 5′-GMP; Fig. S4: cytotoxic profiles of 1 towards cancerous cell lines; Fig. S5: antiproliferative effects of 1 and cisplatin in HeLa and HepG2 for 72 h; Fig. S6: cytotoxic profiles of 1 and cisplatin towards CCD-19Lu cells; Fig. S7: flow cytometr

A nitridoosmium( vi ) complex [Os VI (N)(sap)(OH 2 )Cl] (H 2 sap = N -salicylidene-2-aminophenol) displays prominent in vitro and in vivo anti-cancer properties, induces S- and G2/M-phase arrest and forms a stable adduct with dianionic 5′-guanosine monophosphate. A nitridoosmium( vi ) complex [Os VI (N)(sap)(OH 2 )Cl] (H 2 sap = N -salicylidene-2-aminophenol) displays prominent in vitro and in vivo anti-cancer properties, induces S- and G2/M-phase arrest and forms a stable adduct with dianionic 5′-guanosine monophosphate.