Chemoenzymatic synthesis of (2S)-2-arylpropanols through a dynamic kinetic resolution of 2-arylpropanals with alcohol dehydrogenasesElectronic supplementary information (ESI) available: Synthesis and spectroscopic data of 2-arylpropanals 1b-f, HPLC analyses and procedure for oxidation of (2S)-arylpropanols 2c and 2d to (2S)-2-arylpropionic acids. See DOI: 10.1039/c005098a

We applied Horse Liver Alcohol Dehydrogenase (HLADH) to the enantioselective synthesis of six (2 S )-2-arylpropanols, useful intermediates in the synthesis of Profens. The influence of substrate structure and reaction conditions on yields and enantioselectivity were investigated. The high yields and...

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Hauptverfasser:	Galletti, Paola, Emer, Enrico, Gucciardo, Gabriele, Quintavalla, Arianna, Pori, Matteo, Giacomini, Daria
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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