Synthesis and evaluation of indazole based analog sensitive Akt inhibitorsElectronic supplementary information (ESI) available: Supplementary Table 1. See DOI: 10.1039/c003917aThis article is part of a Molecular BioSystems themed issue on Chemical Genomics

The kinase Akt is a key signaling node in regulating cellular growth and survival. It is implicated in cancer by mutation and its role in the downstream transmission of aberrant PI3K signaling. For these reasons, Akt has become an increasingly important target of drug development efforts and several...

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Hauptverfasser:	Okuzumi, Tatsuya, Ducker, Gregory S, Zhang, Chao, Aizenstein, Brian, Hoffman, Randy, Shokat, Kevan M
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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