A bioorthogonal chemistry strategy for probing protein lipidation in live cellsThis article is part of the 2010 Molecular BioSystems 'Emerging Investigators' issue: highlighting the work of outstanding young scientists at the chemical- and systems-biology interfaces.Electronic supplementary information (ESI) available: Full experimental details and compound characterization data. See DOI: 10.1039/c003470c

We report a chemical lipidation model for the study of protein lipidations in vitro and in live mammalian cells based on a bioorthogonal, photoinduced tetrazole-alkene cycloaddition reaction. We report a chemical lipidation model for the study of protein lipidations in vitro and in live mammalian cells based on a bioorthogonal, photoinduced tetrazole-alkene cycloaddition reaction.