Therapeutic targeting in the silent era: advances in non-viral siRNA delivery

Gene silencing using RNA-interference, first described in mammalian systems almost a decade ago, is revolutionizing therapeutic target validation efforts both in vitro and in vivo . Moreover, the potential for using short interfering RNA (siRNA) as a therapy in its own right is also progressing at a...

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Veröffentlicht in:	Molecular bioSystems 2010-01, Vol.6 (7), p.1143-1161
Hauptverfasser:	Guo, Jianfeng, Fisher, Karen A, Darcy, Raphael, Cryan, John F, O'Driscoll, Caitriona
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Clinical Trials as Topic Drug Delivery Systems - methods Humans Macular Degeneration - genetics Macular Degeneration - therapy Neoplasms - genetics Neoplasms - therapy RNA Interference RNA, Small Interfering - administration & dosage RNA, Small Interfering - genetics Technology, Pharmaceutical - methods
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