Structural Requirements for Antibacterial Activity and $\beta$-Lactamase Stability of 7$\beta$-Arylmalonylamino-7$\alpha$-Methoxy-1-Oxacephems

Replacement of a sulphur atom by an oxygen at the 1-position of the cephem nucleus generally resulted in fourfold to sixteenfold increase of antibacterial activity in each pair of the structural congeners. However, the increased antibacterial activity caused by the replacement was accompanied by ins...

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