The Docking Manoeuvre at a Drug Receptor: A Quantum Mechanical Study of Intercalative Attack of Ethidium and its Carboxylated Derivative on a DNA Fragment

Various semi-empirical quantum mechanical methods have been used to investigate the docking manoeuvre of ethidium and of its carboxylated derivative at the (dC-dG) • (dC-dG) receptor. The objective of the work was to determine whether the drug attacks the receptor in a random orientation or is pre-a...

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Veröffentlicht in:	Philosophical transactions of the Royal Society of London. Series B, Biological sciences Biological sciences, 1979-12, Vol.287 (1025), p.571-604
Hauptverfasser:	Dean, P. M., Wakelin, L. P. G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Atoms Chemical Phenomena Chemistry, Physical DNA - metabolism Drug interactions Electric fields Electrostatic fields Electrostatics Energy Ethidium - metabolism Intercalating Agents Kinetics Ligands Molecular interactions Molecules Nucleic Acid Conformation Oligodeoxyribonucleotides Receptors Receptors, Drug
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