Fatal attraction in rats infected with Toxoplasma gondii
We tested the hypothesis that the parasite Toxoplasma gondii manipulates the behaviour of its intermediate rat host in order to increase its chance of being predated by cats, its feline definitive host, thereby ensuring the completion of its life cycle. Here we report that, although rats have evolve...
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| Veröffentlicht in: | Proceedings of the Royal Society. B, Biological sciences Biological sciences, 2000-08, Vol.267 (1452), p.1591-1594 |
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| container_title | Proceedings of the Royal Society. B, Biological sciences |
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| creator | Berdoy, M. Webster, J. P. Macdonald, D. W. |
| description | We tested the hypothesis that the parasite Toxoplasma gondii manipulates the behaviour of its intermediate rat host in order to increase its chance of being predated by cats, its feline definitive host, thereby ensuring the completion of its life cycle. Here we report that, although rats have evolved anti-predator avoidance of areas with signs of cat presence, T. gondii's manipulation appears to alter the rat's perception of cat predation risk, in some cases turning their innate aversion into an imprudent attraction. The selectivity of such behavioural changes suggests that this ubiquitous parasite subtly alters the brain of its intermediate host to enhance predation rate whilst leaving other behavioural categories and general health intact. This is in contrast to the gross impediments frequently characteristic of many other host-parasite systems. We discuss our results in terms of their potential implications both for the epidemiology of toxoplasmosis and the neurological basis of anxiety and cognitive processes in humans and other mammals. |
| doi_str_mv | 10.1098/rspb.2000.1182 |
| format | Article |
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P.</creatorcontrib><creatorcontrib>Macdonald, D. W.</creatorcontrib><title>Fatal attraction in rats infected with Toxoplasma gondii</title><title>Proceedings of the Royal Society. B, Biological sciences</title><addtitle>Proc Biol Sci</addtitle><description>We tested the hypothesis that the parasite Toxoplasma gondii manipulates the behaviour of its intermediate rat host in order to increase its chance of being predated by cats, its feline definitive host, thereby ensuring the completion of its life cycle. Here we report that, although rats have evolved anti-predator avoidance of areas with signs of cat presence, T. gondii's manipulation appears to alter the rat's perception of cat predation risk, in some cases turning their innate aversion into an imprudent attraction. The selectivity of such behavioural changes suggests that this ubiquitous parasite subtly alters the brain of its intermediate host to enhance predation rate whilst leaving other behavioural categories and general health intact. This is in contrast to the gross impediments frequently characteristic of many other host-parasite systems. We discuss our results in terms of their potential implications both for the epidemiology of toxoplasmosis and the neurological basis of anxiety and cognitive processes in humans and other mammals.</description><subject>Animals</subject><subject>Anxiety</subject><subject>Behavior, Animal</subject><subject>Cat Odours</subject><subject>Cats</subject><subject>Host-Parasite Interactions</subject><subject>Infections</subject><subject>Odors</subject><subject>Parasite hosts</subject><subject>Parasite Manipulation</subject><subject>Parasites</subject><subject>Parasitism</subject><subject>Parasitology</subject><subject>Predation</subject><subject>Rats</subject><subject>Rattus Norvegicus</subject><subject>Toxoplasma - physiology</subject><subject>Toxoplasma Gondii</subject><subject>Toxoplasmosis</subject><subject>Toxoplasmosis - physiopathology</subject><issn>0962-8452</issn><issn>1471-2954</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk2P0zAQhiMEYkvhygmhnLil-CO24wsCVhQQK1gtC-JmuY7duqRxsJ3dLb8ep6kKFWI5WaN55p0Zv5NljyGYQcCr5z50ixkCIIWwQneyCSwZLBAn5d1sAjhFRVUSdJI9CGGdKE4qcj87gRAAhjGdZNVcRtnkMkYvVbSuzW2bexlDeo1WUdf5tY2r_NLduK6RYSPzpWtrax9m94xsgn60f6fZl_mby9N3xdmnt-9PX50VilZVLBAlBBmpJEWylGahS4oUUQRjjrGUhqmFIlRjxiuKSl6bEhtgeAkNB6pGFZ5mL0bdrl9sdK10myZtROftRvqtcNKK40xrV2LprgSkHDAAk8CzvYB3P3odotjYoHTTyFa7PgiGEEeQgv-CkDFUJskEzkZQeReC1-YwDQRicEUMrojBFTG4kgqe_rnDb3xvQwLwCHi3TZ_plNVxK9au920K_y0bbqu6-Hz-GnIOrhBlFqYrEKDCELCygkj8tN1ObgBEAoQNoddihx23-bvrk7HrOkTnD7sgSglL20yzYkzbEPXNIS39d0EZZkR8rUrxjXz8UKKLczFPPBr5lV2urq3X4mibFHQ-LHYj7oaDhA-evry1aJhYuTamkziuFKZv0vHUBv8C89kAsA</recordid><startdate>20000807</startdate><enddate>20000807</enddate><creator>Berdoy, M.</creator><creator>Webster, J. P.</creator><creator>Macdonald, D. W.</creator><general>The Royal Society</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7SN</scope><scope>C1K</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20000807</creationdate><title>Fatal attraction in rats infected with Toxoplasma gondii</title><author>Berdoy, M. ; Webster, J. P. ; Macdonald, D. 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P.</creatorcontrib><creatorcontrib>Macdonald, D. W.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Ecology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the Royal Society. B, Biological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Berdoy, M.</au><au>Webster, J. P.</au><au>Macdonald, D. W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fatal attraction in rats infected with Toxoplasma gondii</atitle><jtitle>Proceedings of the Royal Society. B, Biological sciences</jtitle><addtitle>Proc Biol Sci</addtitle><date>2000-08-07</date><risdate>2000</risdate><volume>267</volume><issue>1452</issue><spage>1591</spage><epage>1594</epage><pages>1591-1594</pages><issn>0962-8452</issn><eissn>1471-2954</eissn><abstract>We tested the hypothesis that the parasite Toxoplasma gondii manipulates the behaviour of its intermediate rat host in order to increase its chance of being predated by cats, its feline definitive host, thereby ensuring the completion of its life cycle. Here we report that, although rats have evolved anti-predator avoidance of areas with signs of cat presence, T. gondii's manipulation appears to alter the rat's perception of cat predation risk, in some cases turning their innate aversion into an imprudent attraction. The selectivity of such behavioural changes suggests that this ubiquitous parasite subtly alters the brain of its intermediate host to enhance predation rate whilst leaving other behavioural categories and general health intact. This is in contrast to the gross impediments frequently characteristic of many other host-parasite systems. We discuss our results in terms of their potential implications both for the epidemiology of toxoplasmosis and the neurological basis of anxiety and cognitive processes in humans and other mammals.</abstract><cop>England</cop><pub>The Royal Society</pub><pmid>11007336</pmid><doi>10.1098/rspb.2000.1182</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; PubMed Central |
| subjects | Animals Anxiety Behavior, Animal Cat Odours Cats Host-Parasite Interactions Infections Odors Parasite hosts Parasite Manipulation Parasites Parasitism Parasitology Predation Rats Rattus Norvegicus Toxoplasma - physiology Toxoplasma Gondii Toxoplasmosis Toxoplasmosis - physiopathology |
| title | Fatal attraction in rats infected with Toxoplasma gondii |
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