Structural and functional analysis of Oceanobacillus iheyensis macrodomain reveals a network of waters involved in substrate binding and catalysis

Macrodomains are ubiquitous conserved domains that bind or transform ADP-ribose (ADPr) metabolites. In humans, they are involved in transcription, X-chromosome inactivation, neurodegeneration and modulating PARP1 signalling, making them potential targets for therapeutic agents. Unfortunately, some a...

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Veröffentlicht in:	Open biology 2017-04, Vol.7 (4), p.160327
Hauptverfasser:	Zapata-Pérez, Rubén, Gil-Ortiz, Fernando, Martínez-Moñino, Ana Belén, García-Saura, Antonio Ginés, Juanhuix, Jordi, Sánchez-Ferrer, Álvaro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate Ribose - chemistry Adenosine Diphosphate Ribose - metabolism Bacillaceae - metabolism Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Binding Sites Biocatalysis Catalytic Mechanism Crystal Structure Crystallography, X-Ray Humans Hydrogen Bonding Hydrolysis Kinetic Characterization Kinetics Macrodomains Molecular Dynamics Simulation Mutagenesis, Site-Directed Mutational Analysis O-Acetyl-ADP-Ribose - chemical synthesis O-Acetyl-ADP-Ribose - metabolism Poly(ADP-ribose) Polymerases - chemistry Poly(ADP-ribose) Polymerases - genetics Poly(ADP-ribose) Polymerases - metabolism Protein Binding Protein Structure, Tertiary Substrate Specificity Temperature Water - chemistry Water - metabolism
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