Maintenance of phenotypic diversity within a set of virulence encoding genes of the malaria parasite Plasmodium falciparum

Infection by the human malaria parasite Plasmodium falciparum results in a broad spectrum of clinical outcomes, ranging from severe and potentially life-threatening malaria to asymptomatic carriage. In a process of naturally acquired immunity, individuals living in malaria-endemic regions build up a...

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Veröffentlicht in:	Journal of the Royal Society interface 2015-12, Vol.12 (113), p.20150848-20150848
Hauptverfasser:	Holding, Thomas, Recker, Mario
Format:	Artikel
Sprache:	eng
Schlagworte:	Evolutionary Trade-Off Female Genes Humans Malaria, Cerebral - genetics Malaria, Cerebral - immunology Malaria, Falciparum - genetics Malaria, Falciparum - immunology Male Mathematical Modelling Models, Genetic Models, Immunological Phenotype Phenotypic Diversity Plasmodium falciparum Plasmodium falciparum - genetics Plasmodium falciparum - immunology Plasmodium falciparum - pathogenicity Pregnancy Pregnancy Complications, Parasitic - genetics Pregnancy Complications, Parasitic - immunology Protozoan Proteins - genetics Protozoan Proteins - immunology Virulence Factors - genetics Virulence Factors - immunology
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