Development of proteolytically stable N-methylated peptide inhibitors of aggregation of the amylin peptide implicated in type 2 diabetes

Islet amyloid polypeptide, also known as amylin, is the main component of the amyloid deposits present in approximately 90% of people with type 2 diabetes mellitus (T2DM). In this disease, amylin aggregates into multimeric β-pleated sheet structures which cause damage to pancreatic islet β-cells. In...

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Veröffentlicht in:	Interface focus 2017-12, Vol.7 (6), p.20160127
Hauptverfasser:	Obasse, Idira, Taylor, Mark, Fullwood, Nigel J., Allsop, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Amylin Amyloid Diabetes Iapp Islet Amyloid Polypeptide N-Methylated Peptide
Online-Zugang:	Volltext
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