Candida auris: A quick review on identification, current treatments, and challenges
Candida auris is a novel and major fungal pathogen that has triggered several outbreaks in the last decade. The few drugs available to treat fungal diseases, the fact that this yeast has a high rate of multidrug resistance and the occurrence of misleading identifications, and the ability of forming...
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| Veröffentlicht in: | International journal of molecular sciences 2021-05, Vol.22 (9), p.4470 |
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| container_issue | 9 |
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| container_title | International journal of molecular sciences |
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| creator | Cernáková, L. Roudbary, M. Brás, Susana Tafaj, S. Rodrigues, Célia F. |
| description | Candida auris is a novel and major fungal pathogen that has triggered several outbreaks in the last decade. The few drugs available to treat fungal diseases, the fact that this yeast has a high rate of multidrug resistance and the occurrence of misleading identifications, and the ability of forming biofilms (naturally more resistant to drugs) has made treatments of C. auris infections highly difficult. This review intends to quickly illustrate the main issues in C. auris identification, available treatments and the associated mechanisms of resistance, and the novel and alternative treatment and drugs (natural and synthetic) that have been recently reported. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
L.. thanks the Slovak Research and Development Agency under contract No. APVV-15-0347 and the grant of VEGA 1/0537/19 from the Ministry of Education, Science, Research, and the Sport of the Slovak Republic. C.F.R. would like to acknowledge the UID/EQU/00511/2020 Project-Laboratory of Process Engineering, Environment, Biotechnology and Energy (LEPABE)-financed by national funds through FCT/MCTES (PIDDAC). |
| doi_str_mv | 10.3390/ijms22094470 |
| format | Article |
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L.. thanks the Slovak Research and Development Agency under contract No. APVV-15-0347 and the grant of VEGA 1/0537/19 from the Ministry of Education, Science, Research, and the Sport of the Slovak Republic. C.F.R. would like to acknowledge the UID/EQU/00511/2020 Project-Laboratory of Process Engineering, Environment, Biotechnology and Energy (LEPABE)-financed by national funds through FCT/MCTES (PIDDAC).</description><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms22094470</identifier><language>eng</language><publisher>MDPI</publisher><subject>Antifungal ; Biofilm ; Candida auris ; Infection ; Novel therapy ; Resistance ; Science & Technology</subject><ispartof>International journal of molecular sciences, 2021-05, Vol.22 (9), p.4470</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids></links><search><creatorcontrib>Cernáková, L.</creatorcontrib><creatorcontrib>Roudbary, M.</creatorcontrib><creatorcontrib>Brás, Susana</creatorcontrib><creatorcontrib>Tafaj, S.</creatorcontrib><creatorcontrib>Rodrigues, Célia F.</creatorcontrib><title>Candida auris: A quick review on identification, current treatments, and challenges</title><title>International journal of molecular sciences</title><description>Candida auris is a novel and major fungal pathogen that has triggered several outbreaks in the last decade. The few drugs available to treat fungal diseases, the fact that this yeast has a high rate of multidrug resistance and the occurrence of misleading identifications, and the ability of forming biofilms (naturally more resistant to drugs) has made treatments of C. auris infections highly difficult. This review intends to quickly illustrate the main issues in C. auris identification, available treatments and the associated mechanisms of resistance, and the novel and alternative treatment and drugs (natural and synthetic) that have been recently reported. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
L.. thanks the Slovak Research and Development Agency under contract No. APVV-15-0347 and the grant of VEGA 1/0537/19 from the Ministry of Education, Science, Research, and the Sport of the Slovak Republic. C.F.R. would like to acknowledge the UID/EQU/00511/2020 Project-Laboratory of Process Engineering, Environment, Biotechnology and Energy (LEPABE)-financed by national funds through FCT/MCTES (PIDDAC).</description><subject>Antifungal</subject><subject>Biofilm</subject><subject>Candida auris</subject><subject>Infection</subject><subject>Novel therapy</subject><subject>Resistance</subject><subject>Science & Technology</subject><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNqNjE0OgjAQRhsTE393HmAOAFoKCLgzRuNe92RSio5i1U7R64uJB3D1vrx8eULMIjmP40Iu6HJjpWSRJJnsiWGUKBVKucwGYsR8kVLFKi2G4rBBW1GFgK0jXsEani3pKzjzIvOGuwWqjPVUk0ZPdxuAbp3rDHhn0N-6xQF0DdBnbBpjT4Ynol9jw2b641jAbnvc7EOnER_lN80euYxypco8jYo0_uPyAfa7QaU</recordid><startdate>20210525</startdate><enddate>20210525</enddate><creator>Cernáková, L.</creator><creator>Roudbary, M.</creator><creator>Brás, Susana</creator><creator>Tafaj, S.</creator><creator>Rodrigues, Célia F.</creator><general>MDPI</general><scope>RCLKO</scope></search><sort><creationdate>20210525</creationdate><title>Candida auris: A quick review on identification, current treatments, and challenges</title><author>Cernáková, L. ; Roudbary, M. ; Brás, Susana ; Tafaj, S. ; Rodrigues, Célia F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-rcaap_revistas_1822_851953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Antifungal</topic><topic>Biofilm</topic><topic>Candida auris</topic><topic>Infection</topic><topic>Novel therapy</topic><topic>Resistance</topic><topic>Science & Technology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cernáková, L.</creatorcontrib><creatorcontrib>Roudbary, M.</creatorcontrib><creatorcontrib>Brás, Susana</creatorcontrib><creatorcontrib>Tafaj, S.</creatorcontrib><creatorcontrib>Rodrigues, Célia F.</creatorcontrib><collection>RCAAP open access repository</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cernáková, L.</au><au>Roudbary, M.</au><au>Brás, Susana</au><au>Tafaj, S.</au><au>Rodrigues, Célia F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Candida auris: A quick review on identification, current treatments, and challenges</atitle><jtitle>International journal of molecular sciences</jtitle><date>2021-05-25</date><risdate>2021</risdate><volume>22</volume><issue>9</issue><spage>4470</spage><pages>4470-</pages><eissn>1422-0067</eissn><abstract>Candida auris is a novel and major fungal pathogen that has triggered several outbreaks in the last decade. The few drugs available to treat fungal diseases, the fact that this yeast has a high rate of multidrug resistance and the occurrence of misleading identifications, and the ability of forming biofilms (naturally more resistant to drugs) has made treatments of C. auris infections highly difficult. This review intends to quickly illustrate the main issues in C. auris identification, available treatments and the associated mechanisms of resistance, and the novel and alternative treatment and drugs (natural and synthetic) that have been recently reported. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
L.. thanks the Slovak Research and Development Agency under contract No. APVV-15-0347 and the grant of VEGA 1/0537/19 from the Ministry of Education, Science, Research, and the Sport of the Slovak Republic. C.F.R. would like to acknowledge the UID/EQU/00511/2020 Project-Laboratory of Process Engineering, Environment, Biotechnology and Energy (LEPABE)-financed by national funds through FCT/MCTES (PIDDAC).</abstract><pub>MDPI</pub><doi>10.3390/ijms22094470</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | EISSN: 1422-0067 |
| ispartof | International journal of molecular sciences, 2021-05, Vol.22 (9), p.4470 |
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| language | eng |
| recordid | cdi_rcaap_revistas_1822_85195 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
| subjects | Antifungal Biofilm Candida auris Infection Novel therapy Resistance Science & Technology |
| title | Candida auris: A quick review on identification, current treatments, and challenges |
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