Pectin-like polysaccharide extracted from leaves Crataeva tapia promotes antioxidant, immunomodulatory and emulsifiers applied in therapeutic formulations
The objective of this work was to isolate a polysaccharide similar to pectin from Crataeva tapia leaves, not yet reported in the literature, and to evaluate its antioxidant, cytotoxic and immunomodulatory profile. Pectin was extracted from the leaves in three stages, organic solvent followed by acid...
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| Veröffentlicht in: | 3 Biotech 2023-04, Vol.13 (4), p.114-114, Article 114 |
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| creator | da Paz Leôncio Alves, Simone Jacob, Iris Trindade Tenório Arruda, Marcela Daniela Muniz da Silva, Abdênego Rodrigues de Sousa, Georon Ferreira de Souza, Guilherme Antônio de Lima, Maria do Carmo Alves de Souza, Ivone Antônia de Melo, Cristiane Moutinho Lagos da Cruz Filho, Iranildo José do Nascimento Santos, Dayane Kelly Dias |
| description | The objective of this work was to isolate a polysaccharide similar to pectin from
Crataeva tapia
leaves, not yet reported in the literature, and to evaluate its antioxidant, cytotoxic and immunomodulatory profile. Pectin was extracted from the leaves in three stages, organic solvent followed by acidified water and ethanol precipitation. With the pectin obtained, the physicochemical characterization of the molecule was carried out using high-performance liquid chromatography, Fourier-transform infrared spectroscopy, nuclear magnetic resonance (
13
C and
1
H) and different thermal and elemental analysis. Furthermore, the antioxidant activities were evaluated in vitro, and using human peripheral blood mononuclear cell culture, cytotoxicity and immunostimulatory actions were investigated. Physical and chemical analyses showed characteristic signs of pectin. Antioxidant activity tests showed that pectin had moderate to low antioxidant activity. Furthermore, pectin did not affect the viability of erythrocytes and PBMC and induced an immunostimulatory state when it promoted the production of cytokines IL-6, IL-10 and TNF-α and increased the activation of CD8 + T lymphocytes. This study showed that pectin from
Crataeva tapia
is not cytotoxic and promoted a pro-inflammatory profile in peripheral blood mononuclear cell with application as an immunostimulating and emulsifying compound. |
| doi_str_mv | 10.1007/s13205-023-03509-y |
| format | Article |
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Crataeva tapia
leaves, not yet reported in the literature, and to evaluate its antioxidant, cytotoxic and immunomodulatory profile. Pectin was extracted from the leaves in three stages, organic solvent followed by acidified water and ethanol precipitation. With the pectin obtained, the physicochemical characterization of the molecule was carried out using high-performance liquid chromatography, Fourier-transform infrared spectroscopy, nuclear magnetic resonance (
13
C and
1
H) and different thermal and elemental analysis. Furthermore, the antioxidant activities were evaluated in vitro, and using human peripheral blood mononuclear cell culture, cytotoxicity and immunostimulatory actions were investigated. Physical and chemical analyses showed characteristic signs of pectin. Antioxidant activity tests showed that pectin had moderate to low antioxidant activity. Furthermore, pectin did not affect the viability of erythrocytes and PBMC and induced an immunostimulatory state when it promoted the production of cytokines IL-6, IL-10 and TNF-α and increased the activation of CD8 + T lymphocytes. This study showed that pectin from
Crataeva tapia
is not cytotoxic and promoted a pro-inflammatory profile in peripheral blood mononuclear cell with application as an immunostimulating and emulsifying compound.</description><identifier>ISSN: 2190-572X</identifier><identifier>ISSN: 2190-5738</identifier><identifier>EISSN: 2190-5738</identifier><identifier>DOI: 10.1007/s13205-023-03509-y</identifier><identifier>PMID: 36909979</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Acidification ; Agriculture ; antioxidant activity ; Antioxidants ; Bioinformatics ; Biomaterials ; Biotechnology ; Blood ; Cancer Research ; CD8 antigen ; Cell activation ; Cell culture ; Chemistry ; Chemistry and Materials Science ; Crataeva tapia ; Crateva tapia ; Cytotoxicity ; Erythrocytes ; Ethanol ; Fourier transform infrared spectroscopy ; Fourier transforms ; High performance liquid chromatography ; humans ; Immunomodulation ; Immunomodulators ; immunostimulants ; Immunostimulation ; Inflammation ; Infrared spectroscopy ; Interleukin 10 ; Interleukin 6 ; Lymphocytes ; Lymphocytes T ; mononuclear leukocytes ; NMR ; Nuclear magnetic resonance ; nuclear magnetic resonance spectroscopy ; Original ; Original Article ; Pectin ; pectins ; Peripheral blood mononuclear cells ; Polysaccharides ; solvents ; Stem Cells ; therapeutics ; Toxicity ; Tumor necrosis factor-α ; viability</subject><ispartof>3 Biotech, 2023-04, Vol.13 (4), p.114-114, Article 114</ispartof><rights>King Abdulaziz City for Science and Technology 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>King Abdulaziz City for Science and Technology 2023, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c414t-a09913513b5d74b7842102da0d59ba99614a705ca24177888348f0a910ea76793</cites><orcidid>0000-0002-5650-1088</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998804/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9998804/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36909979$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>da Paz Leôncio Alves, Simone</creatorcontrib><creatorcontrib>Jacob, Iris Trindade Tenório</creatorcontrib><creatorcontrib>Arruda, Marcela Daniela Muniz</creatorcontrib><creatorcontrib>da Silva, Abdênego Rodrigues</creatorcontrib><creatorcontrib>de Sousa, Georon Ferreira</creatorcontrib><creatorcontrib>de Souza, Guilherme Antônio</creatorcontrib><creatorcontrib>de Lima, Maria do Carmo Alves</creatorcontrib><creatorcontrib>de Souza, Ivone Antônia</creatorcontrib><creatorcontrib>de Melo, Cristiane Moutinho Lagos</creatorcontrib><creatorcontrib>da Cruz Filho, Iranildo José</creatorcontrib><creatorcontrib>do Nascimento Santos, Dayane Kelly Dias</creatorcontrib><title>Pectin-like polysaccharide extracted from leaves Crataeva tapia promotes antioxidant, immunomodulatory and emulsifiers applied in therapeutic formulations</title><title>3 Biotech</title><addtitle>3 Biotech</addtitle><addtitle>3 Biotech</addtitle><description>The objective of this work was to isolate a polysaccharide similar to pectin from
Crataeva tapia
leaves, not yet reported in the literature, and to evaluate its antioxidant, cytotoxic and immunomodulatory profile. Pectin was extracted from the leaves in three stages, organic solvent followed by acidified water and ethanol precipitation. With the pectin obtained, the physicochemical characterization of the molecule was carried out using high-performance liquid chromatography, Fourier-transform infrared spectroscopy, nuclear magnetic resonance (
13
C and
1
H) and different thermal and elemental analysis. Furthermore, the antioxidant activities were evaluated in vitro, and using human peripheral blood mononuclear cell culture, cytotoxicity and immunostimulatory actions were investigated. Physical and chemical analyses showed characteristic signs of pectin. Antioxidant activity tests showed that pectin had moderate to low antioxidant activity. Furthermore, pectin did not affect the viability of erythrocytes and PBMC and induced an immunostimulatory state when it promoted the production of cytokines IL-6, IL-10 and TNF-α and increased the activation of CD8 + T lymphocytes. This study showed that pectin from
Crataeva tapia
is not cytotoxic and promoted a pro-inflammatory profile in peripheral blood mononuclear cell with application as an immunostimulating and emulsifying compound.</description><subject>Acidification</subject><subject>Agriculture</subject><subject>antioxidant activity</subject><subject>Antioxidants</subject><subject>Bioinformatics</subject><subject>Biomaterials</subject><subject>Biotechnology</subject><subject>Blood</subject><subject>Cancer Research</subject><subject>CD8 antigen</subject><subject>Cell activation</subject><subject>Cell culture</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Crataeva tapia</subject><subject>Crateva tapia</subject><subject>Cytotoxicity</subject><subject>Erythrocytes</subject><subject>Ethanol</subject><subject>Fourier transform infrared spectroscopy</subject><subject>Fourier transforms</subject><subject>High performance liquid chromatography</subject><subject>humans</subject><subject>Immunomodulation</subject><subject>Immunomodulators</subject><subject>immunostimulants</subject><subject>Immunostimulation</subject><subject>Inflammation</subject><subject>Infrared spectroscopy</subject><subject>Interleukin 10</subject><subject>Interleukin 6</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>mononuclear leukocytes</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>nuclear magnetic resonance spectroscopy</subject><subject>Original</subject><subject>Original Article</subject><subject>Pectin</subject><subject>pectins</subject><subject>Peripheral blood mononuclear cells</subject><subject>Polysaccharides</subject><subject>solvents</subject><subject>Stem Cells</subject><subject>therapeutics</subject><subject>Toxicity</subject><subject>Tumor necrosis factor-α</subject><subject>viability</subject><issn>2190-572X</issn><issn>2190-5738</issn><issn>2190-5738</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNqFks2OFCEUhStG40zGeQEXhsSNC0uhgAY2JqbjXzKJLjRxR25X3ZphrCpKoDrTr-LTetse25-FsoFwvnvgwqmqh4I_E5yb51nIhuuaN7LmUnNX7-5Up41wvNZG2rvHdfP5pDrP-ZrT0EI7we9XJ3LluHPGnVbfPmBbwlQP4QuyOQ67DG17BSl0yPCmJGgLdqxPcWQDwhYzWycogFtgBeYAbCYpFtqHqYR4Ezqan7IwjstEQrcMUGLakdoxHJchhz5gInqeh0DOYWLlChPMuJTQsj6mcV8S4pQfVPd6GDKe385n1afXrz6u39YX79-8W7-8qFslVKmBOhFSC7nRnVEbY1UjeNMB77TbgHMrocBw3UKjhDHWWqlsz4EeAsGsjJNn1YuD77xsRuxanKjtwc8pjJB2PkLwfypTuPKXceudc9ZyRQZPbg1S_LpgLn4MucVhgAnjkr0UWq6UaZT9L9oYu6JfskoS-vgv9DouaaKX2FOaulGCE9UcqDbFnBP2x3sL7vdB8YegeAqK_xEUv6OiR793fCz5GQsC5AHIJE2XmH6d_Q_b79D0zTg</recordid><startdate>20230401</startdate><enddate>20230401</enddate><creator>da Paz Leôncio Alves, Simone</creator><creator>Jacob, Iris Trindade Tenório</creator><creator>Arruda, Marcela Daniela Muniz</creator><creator>da Silva, Abdênego Rodrigues</creator><creator>de Sousa, Georon Ferreira</creator><creator>de Souza, Guilherme Antônio</creator><creator>de Lima, Maria do Carmo Alves</creator><creator>de Souza, Ivone Antônia</creator><creator>de Melo, Cristiane Moutinho Lagos</creator><creator>da Cruz Filho, Iranildo José</creator><creator>do Nascimento Santos, Dayane Kelly Dias</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5650-1088</orcidid></search><sort><creationdate>20230401</creationdate><title>Pectin-like polysaccharide extracted from leaves Crataeva tapia promotes antioxidant, immunomodulatory and emulsifiers applied in therapeutic formulations</title><author>da Paz Leôncio Alves, Simone ; Jacob, Iris Trindade Tenório ; Arruda, Marcela Daniela Muniz ; da Silva, Abdênego Rodrigues ; de Sousa, Georon Ferreira ; de Souza, Guilherme Antônio ; de Lima, Maria do Carmo Alves ; de Souza, Ivone Antônia ; de Melo, Cristiane Moutinho Lagos ; da Cruz Filho, Iranildo José ; do Nascimento Santos, Dayane Kelly Dias</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-a09913513b5d74b7842102da0d59ba99614a705ca24177888348f0a910ea76793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Acidification</topic><topic>Agriculture</topic><topic>antioxidant activity</topic><topic>Antioxidants</topic><topic>Bioinformatics</topic><topic>Biomaterials</topic><topic>Biotechnology</topic><topic>Blood</topic><topic>Cancer Research</topic><topic>CD8 antigen</topic><topic>Cell activation</topic><topic>Cell culture</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Crataeva tapia</topic><topic>Crateva tapia</topic><topic>Cytotoxicity</topic><topic>Erythrocytes</topic><topic>Ethanol</topic><topic>Fourier transform infrared spectroscopy</topic><topic>Fourier transforms</topic><topic>High performance liquid chromatography</topic><topic>humans</topic><topic>Immunomodulation</topic><topic>Immunomodulators</topic><topic>immunostimulants</topic><topic>Immunostimulation</topic><topic>Inflammation</topic><topic>Infrared spectroscopy</topic><topic>Interleukin 10</topic><topic>Interleukin 6</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>mononuclear leukocytes</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>nuclear magnetic resonance spectroscopy</topic><topic>Original</topic><topic>Original Article</topic><topic>Pectin</topic><topic>pectins</topic><topic>Peripheral blood mononuclear cells</topic><topic>Polysaccharides</topic><topic>solvents</topic><topic>Stem Cells</topic><topic>therapeutics</topic><topic>Toxicity</topic><topic>Tumor necrosis factor-α</topic><topic>viability</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>da Paz Leôncio Alves, Simone</creatorcontrib><creatorcontrib>Jacob, Iris Trindade Tenório</creatorcontrib><creatorcontrib>Arruda, Marcela Daniela Muniz</creatorcontrib><creatorcontrib>da Silva, Abdênego Rodrigues</creatorcontrib><creatorcontrib>de Sousa, Georon Ferreira</creatorcontrib><creatorcontrib>de Souza, Guilherme Antônio</creatorcontrib><creatorcontrib>de Lima, Maria do Carmo Alves</creatorcontrib><creatorcontrib>de Souza, Ivone Antônia</creatorcontrib><creatorcontrib>de Melo, Cristiane Moutinho Lagos</creatorcontrib><creatorcontrib>da Cruz Filho, Iranildo José</creatorcontrib><creatorcontrib>do Nascimento Santos, Dayane Kelly Dias</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>3 Biotech</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>da Paz Leôncio Alves, Simone</au><au>Jacob, Iris Trindade Tenório</au><au>Arruda, Marcela Daniela Muniz</au><au>da Silva, Abdênego Rodrigues</au><au>de Sousa, Georon Ferreira</au><au>de Souza, Guilherme Antônio</au><au>de Lima, Maria do Carmo Alves</au><au>de Souza, Ivone Antônia</au><au>de Melo, Cristiane Moutinho Lagos</au><au>da Cruz Filho, Iranildo José</au><au>do Nascimento Santos, Dayane Kelly Dias</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pectin-like polysaccharide extracted from leaves Crataeva tapia promotes antioxidant, immunomodulatory and emulsifiers applied in therapeutic formulations</atitle><jtitle>3 Biotech</jtitle><stitle>3 Biotech</stitle><addtitle>3 Biotech</addtitle><date>2023-04-01</date><risdate>2023</risdate><volume>13</volume><issue>4</issue><spage>114</spage><epage>114</epage><pages>114-114</pages><artnum>114</artnum><issn>2190-572X</issn><issn>2190-5738</issn><eissn>2190-5738</eissn><abstract>The objective of this work was to isolate a polysaccharide similar to pectin from
Crataeva tapia
leaves, not yet reported in the literature, and to evaluate its antioxidant, cytotoxic and immunomodulatory profile. Pectin was extracted from the leaves in three stages, organic solvent followed by acidified water and ethanol precipitation. With the pectin obtained, the physicochemical characterization of the molecule was carried out using high-performance liquid chromatography, Fourier-transform infrared spectroscopy, nuclear magnetic resonance (
13
C and
1
H) and different thermal and elemental analysis. Furthermore, the antioxidant activities were evaluated in vitro, and using human peripheral blood mononuclear cell culture, cytotoxicity and immunostimulatory actions were investigated. Physical and chemical analyses showed characteristic signs of pectin. Antioxidant activity tests showed that pectin had moderate to low antioxidant activity. Furthermore, pectin did not affect the viability of erythrocytes and PBMC and induced an immunostimulatory state when it promoted the production of cytokines IL-6, IL-10 and TNF-α and increased the activation of CD8 + T lymphocytes. This study showed that pectin from
Crataeva tapia
is not cytotoxic and promoted a pro-inflammatory profile in peripheral blood mononuclear cell with application as an immunostimulating and emulsifying compound.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>36909979</pmid><doi>10.1007/s13205-023-03509-y</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-5650-1088</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acidification Agriculture antioxidant activity Antioxidants Bioinformatics Biomaterials Biotechnology Blood Cancer Research CD8 antigen Cell activation Cell culture Chemistry Chemistry and Materials Science Crataeva tapia Crateva tapia Cytotoxicity Erythrocytes Ethanol Fourier transform infrared spectroscopy Fourier transforms High performance liquid chromatography humans Immunomodulation Immunomodulators immunostimulants Immunostimulation Inflammation Infrared spectroscopy Interleukin 10 Interleukin 6 Lymphocytes Lymphocytes T mononuclear leukocytes NMR Nuclear magnetic resonance nuclear magnetic resonance spectroscopy Original Original Article Pectin pectins Peripheral blood mononuclear cells Polysaccharides solvents Stem Cells therapeutics Toxicity Tumor necrosis factor-α viability |
| title | Pectin-like polysaccharide extracted from leaves Crataeva tapia promotes antioxidant, immunomodulatory and emulsifiers applied in therapeutic formulations |
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