Efficient controlled release of cannabinoids loaded in γ-CD-MOFs and DPPC liposomes as novel delivery systems in oral health
Olivetol (OLV), as a cannabidiol (CBD) analog, was incorporated in γ-cyclodextrin metal-organic frameworks (γ-CD-MOFs) and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) liposomes as potential analgesic drug delivery systems (DDS) for dental hypersensitivity (DH) treatment. These DDS have been s...
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| Veröffentlicht in: | Mikrochimica acta (1966) 2023-04, Vol.190 (4), p.125-125, Article 125 |
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| container_title | Mikrochimica acta (1966) |
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| creator | Rodríguez-Martínez, Jorge Sánchez-Martín, María-Jesús Valiente, Manuel |
| description | Olivetol (OLV), as a cannabidiol (CBD) analog, was incorporated in γ-cyclodextrin metal-organic frameworks (γ-CD-MOFs) and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) liposomes as potential analgesic drug delivery systems (DDS) for dental hypersensitivity (DH) treatment. These DDS have been scarcely employed in oral health, being the first time in case of MOFs loaded with cannabinoids.
In vitro
experiments using bovine teeth were performed to verify if the drug is able to reach the dentin, where it can flow to the pulp tissues and exert its analgesic effect; enamel and dentin regions were analyzed by synchrotron radiation-based FTIR microspectroscopy. Principal component analysis (PCA) was used to process the spectroscopic data as a powerful chemometric tool, and it revealed a similar behavior in both regions. The studied DDS have been characterized by different techniques, and is was demonstrated that DDS is an efficient way to carry the drug through dental tissues without compromising their structure.
Graphical Abstract |
| doi_str_mv | 10.1007/s00604-023-05692-4 |
| format | Article |
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In vitro
experiments using bovine teeth were performed to verify if the drug is able to reach the dentin, where it can flow to the pulp tissues and exert its analgesic effect; enamel and dentin regions were analyzed by synchrotron radiation-based FTIR microspectroscopy. Principal component analysis (PCA) was used to process the spectroscopic data as a powerful chemometric tool, and it revealed a similar behavior in both regions. The studied DDS have been characterized by different techniques, and is was demonstrated that DDS is an efficient way to carry the drug through dental tissues without compromising their structure.
Graphical Abstract</description><identifier>ISSN: 0026-3672</identifier><identifier>EISSN: 1436-5073</identifier><identifier>DOI: 10.1007/s00604-023-05692-4</identifier><identifier>PMID: 36894805</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Analytical Chemistry ; Animals ; Cannabinoids ; Cattle ; Characterization and Evaluation of Materials ; Chemistry ; Chemistry and Materials Science ; Delayed-Action Preparations ; gamma-Cyclodextrins - chemistry ; Liposomes - chemistry ; Metal-Organic Frameworks - chemistry ; Microengineering ; Nanochemistry ; Nanotechnology ; Oral Health ; Original Paper</subject><ispartof>Mikrochimica acta (1966), 2023-04, Vol.190 (4), p.125-125, Article 125</ispartof><rights>The Author(s) 2023</rights><rights>2023. The Author(s).</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c446t-a28d9d40eb26a57865bdb01c5228363c127898f872dabad1d4aa5ac031546a8b3</citedby><cites>FETCH-LOGICAL-c446t-a28d9d40eb26a57865bdb01c5228363c127898f872dabad1d4aa5ac031546a8b3</cites><orcidid>0000-0003-1678-6055</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00604-023-05692-4$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00604-023-05692-4$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36894805$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rodríguez-Martínez, Jorge</creatorcontrib><creatorcontrib>Sánchez-Martín, María-Jesús</creatorcontrib><creatorcontrib>Valiente, Manuel</creatorcontrib><title>Efficient controlled release of cannabinoids loaded in γ-CD-MOFs and DPPC liposomes as novel delivery systems in oral health</title><title>Mikrochimica acta (1966)</title><addtitle>Microchim Acta</addtitle><addtitle>Mikrochim Acta</addtitle><description>Olivetol (OLV), as a cannabidiol (CBD) analog, was incorporated in γ-cyclodextrin metal-organic frameworks (γ-CD-MOFs) and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) liposomes as potential analgesic drug delivery systems (DDS) for dental hypersensitivity (DH) treatment. These DDS have been scarcely employed in oral health, being the first time in case of MOFs loaded with cannabinoids.
In vitro
experiments using bovine teeth were performed to verify if the drug is able to reach the dentin, where it can flow to the pulp tissues and exert its analgesic effect; enamel and dentin regions were analyzed by synchrotron radiation-based FTIR microspectroscopy. Principal component analysis (PCA) was used to process the spectroscopic data as a powerful chemometric tool, and it revealed a similar behavior in both regions. The studied DDS have been characterized by different techniques, and is was demonstrated that DDS is an efficient way to carry the drug through dental tissues without compromising their structure.
Graphical Abstract</description><subject>Analytical Chemistry</subject><subject>Animals</subject><subject>Cannabinoids</subject><subject>Cattle</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Delayed-Action Preparations</subject><subject>gamma-Cyclodextrins - chemistry</subject><subject>Liposomes - chemistry</subject><subject>Metal-Organic Frameworks - chemistry</subject><subject>Microengineering</subject><subject>Nanochemistry</subject><subject>Nanotechnology</subject><subject>Oral Health</subject><subject>Original Paper</subject><issn>0026-3672</issn><issn>1436-5073</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9UctuEzEUtRCIpoEfYIG8ZONy_RiPZ4OE0haQitoFrC2P7WlcOXawJ5Gy4Kv4D74Jl5QKNqyu5PO45_og9IrCGQXo31YACYIA4wQ6OTAinqAFFVySDnr-FC0AmCRc9uwEndZ6B0B7ycRzdMKlGoSCboG-X0xTsMGnGduc5pJj9A4XH72pHucJW5OSGUPKwVUcs3ENDgn__EFW5-Tz9WXFJjl8fnOzwjFsc80b354qTnnvI3Y-hr0vB1wPdfabei_NxUS89ibO6xfo2WRi9S8f5hJ9vbz4svpIrq4_fFq9vyJWCDkTw5QbnAA_Mmm6XsludCNQ2zGmuOSWsl4NalI9c2Y0jjphTGcscNoJadTIl-jd0Xe7Gzfe2XZuC6G3JWxMOehsgv4XSWGtb_NeD8OgOOXN4M2DQcnfdr7OehOq9TGa5POu6hZAwsB54y4RO1JtybUWPz2uoaDve9PH3nTrTf_uTYsmev13wEfJn6IagR8JtUHp1hd9l3cltU_7n-0vaVamEg</recordid><startdate>20230401</startdate><enddate>20230401</enddate><creator>Rodríguez-Martínez, Jorge</creator><creator>Sánchez-Martín, María-Jesús</creator><creator>Valiente, Manuel</creator><general>Springer Vienna</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1678-6055</orcidid></search><sort><creationdate>20230401</creationdate><title>Efficient controlled release of cannabinoids loaded in γ-CD-MOFs and DPPC liposomes as novel delivery systems in oral health</title><author>Rodríguez-Martínez, Jorge ; Sánchez-Martín, María-Jesús ; Valiente, Manuel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c446t-a28d9d40eb26a57865bdb01c5228363c127898f872dabad1d4aa5ac031546a8b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Analytical Chemistry</topic><topic>Animals</topic><topic>Cannabinoids</topic><topic>Cattle</topic><topic>Characterization and Evaluation of Materials</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Delayed-Action Preparations</topic><topic>gamma-Cyclodextrins - chemistry</topic><topic>Liposomes - chemistry</topic><topic>Metal-Organic Frameworks - chemistry</topic><topic>Microengineering</topic><topic>Nanochemistry</topic><topic>Nanotechnology</topic><topic>Oral Health</topic><topic>Original Paper</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rodríguez-Martínez, Jorge</creatorcontrib><creatorcontrib>Sánchez-Martín, María-Jesús</creatorcontrib><creatorcontrib>Valiente, Manuel</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Mikrochimica acta (1966)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rodríguez-Martínez, Jorge</au><au>Sánchez-Martín, María-Jesús</au><au>Valiente, Manuel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficient controlled release of cannabinoids loaded in γ-CD-MOFs and DPPC liposomes as novel delivery systems in oral health</atitle><jtitle>Mikrochimica acta (1966)</jtitle><stitle>Microchim Acta</stitle><addtitle>Mikrochim Acta</addtitle><date>2023-04-01</date><risdate>2023</risdate><volume>190</volume><issue>4</issue><spage>125</spage><epage>125</epage><pages>125-125</pages><artnum>125</artnum><issn>0026-3672</issn><eissn>1436-5073</eissn><abstract>Olivetol (OLV), as a cannabidiol (CBD) analog, was incorporated in γ-cyclodextrin metal-organic frameworks (γ-CD-MOFs) and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) liposomes as potential analgesic drug delivery systems (DDS) for dental hypersensitivity (DH) treatment. These DDS have been scarcely employed in oral health, being the first time in case of MOFs loaded with cannabinoids.
In vitro
experiments using bovine teeth were performed to verify if the drug is able to reach the dentin, where it can flow to the pulp tissues and exert its analgesic effect; enamel and dentin regions were analyzed by synchrotron radiation-based FTIR microspectroscopy. Principal component analysis (PCA) was used to process the spectroscopic data as a powerful chemometric tool, and it revealed a similar behavior in both regions. The studied DDS have been characterized by different techniques, and is was demonstrated that DDS is an efficient way to carry the drug through dental tissues without compromising their structure.
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| source | MEDLINE; SpringerLink Journals (MCLS) |
| subjects | Analytical Chemistry Animals Cannabinoids Cattle Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Delayed-Action Preparations gamma-Cyclodextrins - chemistry Liposomes - chemistry Metal-Organic Frameworks - chemistry Microengineering Nanochemistry Nanotechnology Oral Health Original Paper |
| title | Efficient controlled release of cannabinoids loaded in γ-CD-MOFs and DPPC liposomes as novel delivery systems in oral health |
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