Association of macular OCT and OCTA parameters with visual acuity in glaucoma
Background/aimsTo investigate the association of macular optical coherence tomography (OCT)/OCT angiography (OCTA) parameters with visual acuity (VA) in glaucoma.Methods144 pseudophakic primary open-angle glaucoma eyes were included. Foveal (fVD), parafoveal (pf), perifoveal (perifVD) and whole-imag...
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| Veröffentlicht in: | British journal of ophthalmology 2023-11, Vol.107 (11), p.1652-1657 |
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| creator | Wu, Jo-Hsuan Moghimi, Sasan Nishida, Takashi Mohammadzadeh, Vahid Kamalipour, Alireza Zangwill, Linda M Weinreb, Robert N |
| description | Background/aimsTo investigate the association of macular optical coherence tomography (OCT)/OCT angiography (OCTA) parameters with visual acuity (VA) in glaucoma.Methods144 pseudophakic primary open-angle glaucoma eyes were included. Foveal (fVD), parafoveal (pf), perifoveal (perifVD) and whole-image vessel densities (wiVD) of superficial and deep layers, and their corresponding ganglion cell complex (GCC) thicknesses were obtained from OCTA 6×6 mm2 macula scans. Foveal avascular zone (FAZ) area, FAZ circumference and foveal density-300 (FD300) were measured. Correlation between OCT/OCTA parameters and Logarithm of the Minimum Angle of Resolution VA (logMAR VA) in early and moderate-advanced glaucoma was evaluated with age and Signal Strength Index-adjusted mixed models. Area under receiver operating characteristic (AUC) was used to evaluate discriminative power of OCT/OCTA for decreased VA ( |
| doi_str_mv | 10.1136/bjo-2022-321460 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9995602</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2716090064</sourcerecordid><originalsourceid>FETCH-LOGICAL-b416t-e0e9536ccc989980c7589d3435f77c2156766785565c1ea46062f8e8b7385cd33</originalsourceid><addsrcrecordid>eNp1kclLAzEYxYMoti5nbxLwIsholma7CKW4QcWLnkMmzdSUmUlNZhT_e1OqdQFPL8sv78vjAXCE0TnGlF-Ui1AQREhBCR5xtAWGWWQ-EmobDBFCosCY4wHYS2mRt4RjsQsGlOO8QmoI7scpBetN50MLQwUbY_vaRPgweYSmna10DJcmmsZ1Lib45rtn-OpTb2qYUd-9Q9_CeW16GxpzAHYqUyd3-Kn74On66nFyW0wfbu4m42lRjjDvCoecYpRba5VUSiIrmFQzOqKsEsISzLjgXEjGOLPYmRyMk0o6WQoqmZ1Rug8u177LvmzczLq2i6bWy-gbE991MF7_vmn9s56HV62UYhyRbHD6aRDDS-9SpxufrKtr07rQJ00E5kghxEcZPfmDLkIf2xxPEykUIpJTlqmLNWVjSCm6avMZjPSqKp2r0quq9Lqq_OL4Z4YN_9VNBs7WQNksvmf-Z_cB_lubEA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2879028635</pqid></control><display><type>article</type><title>Association of macular OCT and OCTA parameters with visual acuity in glaucoma</title><source>MEDLINE</source><source>PubMed Central</source><creator>Wu, Jo-Hsuan ; Moghimi, Sasan ; Nishida, Takashi ; Mohammadzadeh, Vahid ; Kamalipour, Alireza ; Zangwill, Linda M ; Weinreb, Robert N</creator><creatorcontrib>Wu, Jo-Hsuan ; Moghimi, Sasan ; Nishida, Takashi ; Mohammadzadeh, Vahid ; Kamalipour, Alireza ; Zangwill, Linda M ; Weinreb, Robert N</creatorcontrib><description>Background/aimsTo investigate the association of macular optical coherence tomography (OCT)/OCT angiography (OCTA) parameters with visual acuity (VA) in glaucoma.Methods144 pseudophakic primary open-angle glaucoma eyes were included. Foveal (fVD), parafoveal (pf), perifoveal (perifVD) and whole-image vessel densities (wiVD) of superficial and deep layers, and their corresponding ganglion cell complex (GCC) thicknesses were obtained from OCTA 6×6 mm2 macula scans. Foveal avascular zone (FAZ) area, FAZ circumference and foveal density-300 (FD300) were measured. Correlation between OCT/OCTA parameters and Logarithm of the Minimum Angle of Resolution VA (logMAR VA) in early and moderate-advanced glaucoma was evaluated with age and Signal Strength Index-adjusted mixed models. Area under receiver operating characteristic (AUC) was used to evaluate discriminative power of OCT/OCTA for decreased VA (<20/25).ResultsIn early glaucoma (80 eyes), no parameter correlated with VA. In moderate-advanced glaucoma (64 eyes), greater FAZ area (β=0.228) and circumference (β=0.063) correlated with worse VA (p<0.05), but not FD300. fThinner sectoral and global GCC was associated with worse VA (β=0.002–0.003, p<0.05), except for inferior hemifield perifGCC and wiGCC. For VD, lower superior hemifield superficial perifVD and wiVD (β=0.007–0.008) and deep fVD (β=0.004) correlated with worse VA (p<0.05). OCT/OCTA parameters showed modest ability to discriminate decreased VA, with the superior hemifield performing better than the inferior hemifield. In early glaucoma, GCC and VD showed similar discrimination (AUC=0.67–0.77). In moderate-advanced glaucoma, fGCC and pfGCC yielded higher AUC (0.75–0.81) than VD (AUC=0.63–0.72).ConclusionsSome macular OCT/OCTA parameters were associated with VA in moderate-advanced, but not early glaucoma. These structural parameters may help identify glaucoma patients with impaired vision and reduced quality of life.Trial registration number NCT00221897.</description><identifier>ISSN: 0007-1161</identifier><identifier>ISSN: 1468-2079</identifier><identifier>EISSN: 1468-2079</identifier><identifier>DOI: 10.1136/bjo-2022-321460</identifier><identifier>PMID: 36126109</identifier><language>eng</language><publisher>BMA House, Tavistock Square, London, WC1H 9JR: BMJ Publishing Group Ltd</publisher><subject>Automation ; Clinical science ; Fluorescein Angiography - methods ; Glaucoma ; Glaucoma - diagnosis ; Glaucoma, Open-Angle - diagnosis ; Humans ; Medical imaging ; Optics ; Quality of Life ; Retinal Vessels ; Tomography ; Tomography, Optical Coherence - methods ; Vision ; Visual Acuity</subject><ispartof>British journal of ophthalmology, 2023-11, Vol.107 (11), p.1652-1657</ispartof><rights>Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>2023 Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b416t-e0e9536ccc989980c7589d3435f77c2156766785565c1ea46062f8e8b7385cd33</citedby><cites>FETCH-LOGICAL-b416t-e0e9536ccc989980c7589d3435f77c2156766785565c1ea46062f8e8b7385cd33</cites><orcidid>0000-0002-9435-746X ; 0000-0001-9553-3202 ; 0000-0002-8312-6623 ; 0000-0002-1143-5224</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995602/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995602/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36126109$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Jo-Hsuan</creatorcontrib><creatorcontrib>Moghimi, Sasan</creatorcontrib><creatorcontrib>Nishida, Takashi</creatorcontrib><creatorcontrib>Mohammadzadeh, Vahid</creatorcontrib><creatorcontrib>Kamalipour, Alireza</creatorcontrib><creatorcontrib>Zangwill, Linda M</creatorcontrib><creatorcontrib>Weinreb, Robert N</creatorcontrib><title>Association of macular OCT and OCTA parameters with visual acuity in glaucoma</title><title>British journal of ophthalmology</title><addtitle>Br J Ophthalmol</addtitle><addtitle>Br J Ophthalmol</addtitle><description>Background/aimsTo investigate the association of macular optical coherence tomography (OCT)/OCT angiography (OCTA) parameters with visual acuity (VA) in glaucoma.Methods144 pseudophakic primary open-angle glaucoma eyes were included. Foveal (fVD), parafoveal (pf), perifoveal (perifVD) and whole-image vessel densities (wiVD) of superficial and deep layers, and their corresponding ganglion cell complex (GCC) thicknesses were obtained from OCTA 6×6 mm2 macula scans. Foveal avascular zone (FAZ) area, FAZ circumference and foveal density-300 (FD300) were measured. Correlation between OCT/OCTA parameters and Logarithm of the Minimum Angle of Resolution VA (logMAR VA) in early and moderate-advanced glaucoma was evaluated with age and Signal Strength Index-adjusted mixed models. Area under receiver operating characteristic (AUC) was used to evaluate discriminative power of OCT/OCTA for decreased VA (<20/25).ResultsIn early glaucoma (80 eyes), no parameter correlated with VA. In moderate-advanced glaucoma (64 eyes), greater FAZ area (β=0.228) and circumference (β=0.063) correlated with worse VA (p<0.05), but not FD300. fThinner sectoral and global GCC was associated with worse VA (β=0.002–0.003, p<0.05), except for inferior hemifield perifGCC and wiGCC. For VD, lower superior hemifield superficial perifVD and wiVD (β=0.007–0.008) and deep fVD (β=0.004) correlated with worse VA (p<0.05). OCT/OCTA parameters showed modest ability to discriminate decreased VA, with the superior hemifield performing better than the inferior hemifield. In early glaucoma, GCC and VD showed similar discrimination (AUC=0.67–0.77). In moderate-advanced glaucoma, fGCC and pfGCC yielded higher AUC (0.75–0.81) than VD (AUC=0.63–0.72).ConclusionsSome macular OCT/OCTA parameters were associated with VA in moderate-advanced, but not early glaucoma. These structural parameters may help identify glaucoma patients with impaired vision and reduced quality of life.Trial registration number NCT00221897.</description><subject>Automation</subject><subject>Clinical science</subject><subject>Fluorescein Angiography - methods</subject><subject>Glaucoma</subject><subject>Glaucoma - diagnosis</subject><subject>Glaucoma, Open-Angle - diagnosis</subject><subject>Humans</subject><subject>Medical imaging</subject><subject>Optics</subject><subject>Quality of Life</subject><subject>Retinal Vessels</subject><subject>Tomography</subject><subject>Tomography, Optical Coherence - methods</subject><subject>Vision</subject><subject>Visual Acuity</subject><issn>0007-1161</issn><issn>1468-2079</issn><issn>1468-2079</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kclLAzEYxYMoti5nbxLwIsholma7CKW4QcWLnkMmzdSUmUlNZhT_e1OqdQFPL8sv78vjAXCE0TnGlF-Ui1AQREhBCR5xtAWGWWQ-EmobDBFCosCY4wHYS2mRt4RjsQsGlOO8QmoI7scpBetN50MLQwUbY_vaRPgweYSmna10DJcmmsZ1Lib45rtn-OpTb2qYUd-9Q9_CeW16GxpzAHYqUyd3-Kn74On66nFyW0wfbu4m42lRjjDvCoecYpRba5VUSiIrmFQzOqKsEsISzLjgXEjGOLPYmRyMk0o6WQoqmZ1Rug8u177LvmzczLq2i6bWy-gbE991MF7_vmn9s56HV62UYhyRbHD6aRDDS-9SpxufrKtr07rQJ00E5kghxEcZPfmDLkIf2xxPEykUIpJTlqmLNWVjSCm6avMZjPSqKp2r0quq9Lqq_OL4Z4YN_9VNBs7WQNksvmf-Z_cB_lubEA</recordid><startdate>20231101</startdate><enddate>20231101</enddate><creator>Wu, Jo-Hsuan</creator><creator>Moghimi, Sasan</creator><creator>Nishida, Takashi</creator><creator>Mohammadzadeh, Vahid</creator><creator>Kamalipour, Alireza</creator><creator>Zangwill, Linda M</creator><creator>Weinreb, Robert N</creator><general>BMJ Publishing Group Ltd</general><general>BMJ Publishing Group LTD</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9435-746X</orcidid><orcidid>https://orcid.org/0000-0001-9553-3202</orcidid><orcidid>https://orcid.org/0000-0002-8312-6623</orcidid><orcidid>https://orcid.org/0000-0002-1143-5224</orcidid></search><sort><creationdate>20231101</creationdate><title>Association of macular OCT and OCTA parameters with visual acuity in glaucoma</title><author>Wu, Jo-Hsuan ; Moghimi, Sasan ; Nishida, Takashi ; Mohammadzadeh, Vahid ; Kamalipour, Alireza ; Zangwill, Linda M ; Weinreb, Robert N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b416t-e0e9536ccc989980c7589d3435f77c2156766785565c1ea46062f8e8b7385cd33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Automation</topic><topic>Clinical science</topic><topic>Fluorescein Angiography - methods</topic><topic>Glaucoma</topic><topic>Glaucoma - diagnosis</topic><topic>Glaucoma, Open-Angle - diagnosis</topic><topic>Humans</topic><topic>Medical imaging</topic><topic>Optics</topic><topic>Quality of Life</topic><topic>Retinal Vessels</topic><topic>Tomography</topic><topic>Tomography, Optical Coherence - methods</topic><topic>Vision</topic><topic>Visual Acuity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Jo-Hsuan</creatorcontrib><creatorcontrib>Moghimi, Sasan</creatorcontrib><creatorcontrib>Nishida, Takashi</creatorcontrib><creatorcontrib>Mohammadzadeh, Vahid</creatorcontrib><creatorcontrib>Kamalipour, Alireza</creatorcontrib><creatorcontrib>Zangwill, Linda M</creatorcontrib><creatorcontrib>Weinreb, Robert N</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Jo-Hsuan</au><au>Moghimi, Sasan</au><au>Nishida, Takashi</au><au>Mohammadzadeh, Vahid</au><au>Kamalipour, Alireza</au><au>Zangwill, Linda M</au><au>Weinreb, Robert N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of macular OCT and OCTA parameters with visual acuity in glaucoma</atitle><jtitle>British journal of ophthalmology</jtitle><stitle>Br J Ophthalmol</stitle><addtitle>Br J Ophthalmol</addtitle><date>2023-11-01</date><risdate>2023</risdate><volume>107</volume><issue>11</issue><spage>1652</spage><epage>1657</epage><pages>1652-1657</pages><issn>0007-1161</issn><issn>1468-2079</issn><eissn>1468-2079</eissn><abstract>Background/aimsTo investigate the association of macular optical coherence tomography (OCT)/OCT angiography (OCTA) parameters with visual acuity (VA) in glaucoma.Methods144 pseudophakic primary open-angle glaucoma eyes were included. Foveal (fVD), parafoveal (pf), perifoveal (perifVD) and whole-image vessel densities (wiVD) of superficial and deep layers, and their corresponding ganglion cell complex (GCC) thicknesses were obtained from OCTA 6×6 mm2 macula scans. Foveal avascular zone (FAZ) area, FAZ circumference and foveal density-300 (FD300) were measured. Correlation between OCT/OCTA parameters and Logarithm of the Minimum Angle of Resolution VA (logMAR VA) in early and moderate-advanced glaucoma was evaluated with age and Signal Strength Index-adjusted mixed models. Area under receiver operating characteristic (AUC) was used to evaluate discriminative power of OCT/OCTA for decreased VA (<20/25).ResultsIn early glaucoma (80 eyes), no parameter correlated with VA. In moderate-advanced glaucoma (64 eyes), greater FAZ area (β=0.228) and circumference (β=0.063) correlated with worse VA (p<0.05), but not FD300. fThinner sectoral and global GCC was associated with worse VA (β=0.002–0.003, p<0.05), except for inferior hemifield perifGCC and wiGCC. For VD, lower superior hemifield superficial perifVD and wiVD (β=0.007–0.008) and deep fVD (β=0.004) correlated with worse VA (p<0.05). OCT/OCTA parameters showed modest ability to discriminate decreased VA, with the superior hemifield performing better than the inferior hemifield. In early glaucoma, GCC and VD showed similar discrimination (AUC=0.67–0.77). In moderate-advanced glaucoma, fGCC and pfGCC yielded higher AUC (0.75–0.81) than VD (AUC=0.63–0.72).ConclusionsSome macular OCT/OCTA parameters were associated with VA in moderate-advanced, but not early glaucoma. These structural parameters may help identify glaucoma patients with impaired vision and reduced quality of life.Trial registration number NCT00221897.</abstract><cop>BMA House, Tavistock Square, London, WC1H 9JR</cop><pub>BMJ Publishing Group Ltd</pub><pmid>36126109</pmid><doi>10.1136/bjo-2022-321460</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-9435-746X</orcidid><orcidid>https://orcid.org/0000-0001-9553-3202</orcidid><orcidid>https://orcid.org/0000-0002-8312-6623</orcidid><orcidid>https://orcid.org/0000-0002-1143-5224</orcidid></addata></record> |
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| subjects | Automation Clinical science Fluorescein Angiography - methods Glaucoma Glaucoma - diagnosis Glaucoma, Open-Angle - diagnosis Humans Medical imaging Optics Quality of Life Retinal Vessels Tomography Tomography, Optical Coherence - methods Vision Visual Acuity |
| title | Association of macular OCT and OCTA parameters with visual acuity in glaucoma |
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