The Drosophila dopamine 2‐like receptor D2R (Dop2R) is required in the blood brain barrier for male courtship
The blood brain barrier (BBB) has the essential function to protect the brain from potentially hazardous molecules while also enabling controlled selective uptake. How these processes and signaling inside BBB cells control neuronal function is an intense area of interest. Signaling in the adult Dros...
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| Veröffentlicht in: | Genes, brain and behavior brain and behavior, 2023-02, Vol.22 (1), p.e12836-n/a |
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| creator | Love, Cameron R. Gautam, Sumit Lama, Chamala Le, Nhu Hoa Dauwalder, Brigitte |
| description | The blood brain barrier (BBB) has the essential function to protect the brain from potentially hazardous molecules while also enabling controlled selective uptake. How these processes and signaling inside BBB cells control neuronal function is an intense area of interest. Signaling in the adult Drosophila BBB is required for normal male courtship behavior and relies on male‐specific molecules in the BBB. Here we show that the dopamine receptor D2R is expressed in the BBB and is required in mature males for normal mating behavior. Conditional adult male knockdown of D2R in BBB cells causes courtship defects. The courtship defects observed in genetic D2R mutants can be rescued by expression of normal D2R specifically in the BBB of adult males. Drosophila BBB cells are glial cells. Our findings thus identify a specific glial function for the DR2 receptor and dopamine signaling in the regulation of a complex behavior. |
| doi_str_mv | 10.1111/gbb.12836 |
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How these processes and signaling inside BBB cells control neuronal function is an intense area of interest. Signaling in the adult Drosophila BBB is required for normal male courtship behavior and relies on male‐specific molecules in the BBB. Here we show that the dopamine receptor D2R is expressed in the BBB and is required in mature males for normal mating behavior. Conditional adult male knockdown of D2R in BBB cells causes courtship defects. The courtship defects observed in genetic D2R mutants can be rescued by expression of normal D2R specifically in the BBB of adult males. Drosophila BBB cells are glial cells. Our findings thus identify a specific glial function for the DR2 receptor and dopamine signaling in the regulation of a complex behavior.</description><identifier>ISSN: 1601-1848</identifier><identifier>EISSN: 1601-183X</identifier><identifier>DOI: 10.1111/gbb.12836</identifier><identifier>PMID: 36636829</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Behavior ; Blood-brain barrier ; Blood-Brain Barrier - metabolism ; Courtship ; Dopamine ; Dopamine - metabolism ; Dopamine D2 receptors ; Drosophila ; Drosophila - physiology ; Drosophila melanogaster - genetics ; Drosophila Proteins - genetics ; Drosophila Proteins - metabolism ; Experiments ; glia ; Glial cells ; Insects ; Male ; Males ; Mating behavior ; Original ; Parkinson's disease ; Proteins ; Schizophrenia ; Sexual Behavior, Animal - physiology ; Variance analysis</subject><ispartof>Genes, brain and behavior, 2023-02, Vol.22 (1), p.e12836-n/a</ispartof><rights>2023 The Authors. Genes, Brain and Behavior published by International Behavioural and Neural Genetics Society and John Wiley & Sons Ltd.</rights><rights>2023. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the "License"). 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How these processes and signaling inside BBB cells control neuronal function is an intense area of interest. Signaling in the adult Drosophila BBB is required for normal male courtship behavior and relies on male‐specific molecules in the BBB. Here we show that the dopamine receptor D2R is expressed in the BBB and is required in mature males for normal mating behavior. Conditional adult male knockdown of D2R in BBB cells causes courtship defects. The courtship defects observed in genetic D2R mutants can be rescued by expression of normal D2R specifically in the BBB of adult males. Drosophila BBB cells are glial cells. Our findings thus identify a specific glial function for the DR2 receptor and dopamine signaling in the regulation of a complex behavior.</description><subject>Animals</subject><subject>Behavior</subject><subject>Blood-brain barrier</subject><subject>Blood-Brain Barrier - metabolism</subject><subject>Courtship</subject><subject>Dopamine</subject><subject>Dopamine - metabolism</subject><subject>Dopamine D2 receptors</subject><subject>Drosophila</subject><subject>Drosophila - physiology</subject><subject>Drosophila melanogaster - genetics</subject><subject>Drosophila Proteins - genetics</subject><subject>Drosophila Proteins - metabolism</subject><subject>Experiments</subject><subject>glia</subject><subject>Glial cells</subject><subject>Insects</subject><subject>Male</subject><subject>Males</subject><subject>Mating behavior</subject><subject>Original</subject><subject>Parkinson's disease</subject><subject>Proteins</subject><subject>Schizophrenia</subject><subject>Sexual Behavior, Animal - physiology</subject><subject>Variance analysis</subject><issn>1601-1848</issn><issn>1601-183X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kc1q3DAQx0VpaD7aQ1-gCHpJDpvow5btS6HJNmkgEAgp9CYkeTarVLYcyW7IrY_QZ-yTZLabLmmhQiBp9Js_M_Mn5C1nhxzX0Y21h1zUUr0gO1wxPuO1_Ppycy_qbbKb8y1jvJI1f0W2pVJS1aLZIfF6CXSeYo7D0gdD2ziYzvdAxa8fP4P_BjSBg2GMic7FFd2fx0FcHVCfMX43-QQt9T0dUcSGGFtqk8G3NSl5SHSBaZ0JQF2c0piXfnhNthYmZHjzdO6RL6efrk8-zy4uz85PPl7MXFFINZMA3CrbOguGS8ttYZyQQlW4magVMs7KBUZZ01SlEAzKVjkphBNW1CD3yIe17jDZDloH_ZhM0EPynUkPOhqv__7p_VLfxO-6aZoCx4QC-08CKd5NkEfd-ewgBNNDnLIWlSqrqijLFfr-H_QW2-2xPaQqUTeMqRV1sKYcTjsnWGyK4UyvbNRoo_5tI7Lvnle_If_4hsDRGrj3AR7-r6TPjo_Xko-8Cqdq</recordid><startdate>202302</startdate><enddate>202302</enddate><creator>Love, Cameron R.</creator><creator>Gautam, Sumit</creator><creator>Lama, Chamala</creator><creator>Le, Nhu Hoa</creator><creator>Dauwalder, Brigitte</creator><general>Blackwell Publishing Ltd</general><general>John Wiley & Sons, Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5593-6090</orcidid></search><sort><creationdate>202302</creationdate><title>The Drosophila dopamine 2‐like receptor D2R (Dop2R) is required in the blood brain barrier for male courtship</title><author>Love, Cameron R. ; Gautam, Sumit ; Lama, Chamala ; Le, Nhu Hoa ; Dauwalder, Brigitte</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4436-3ee1b6bdcbea13b1b4ac232672670286436cb3f4ac09975220e5d6c322c2b28e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Animals</topic><topic>Behavior</topic><topic>Blood-brain barrier</topic><topic>Blood-Brain Barrier - metabolism</topic><topic>Courtship</topic><topic>Dopamine</topic><topic>Dopamine - metabolism</topic><topic>Dopamine D2 receptors</topic><topic>Drosophila</topic><topic>Drosophila - physiology</topic><topic>Drosophila melanogaster - genetics</topic><topic>Drosophila Proteins - genetics</topic><topic>Drosophila Proteins - metabolism</topic><topic>Experiments</topic><topic>glia</topic><topic>Glial cells</topic><topic>Insects</topic><topic>Male</topic><topic>Males</topic><topic>Mating behavior</topic><topic>Original</topic><topic>Parkinson's disease</topic><topic>Proteins</topic><topic>Schizophrenia</topic><topic>Sexual Behavior, Animal - physiology</topic><topic>Variance analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Love, Cameron R.</creatorcontrib><creatorcontrib>Gautam, Sumit</creatorcontrib><creatorcontrib>Lama, Chamala</creatorcontrib><creatorcontrib>Le, Nhu Hoa</creatorcontrib><creatorcontrib>Dauwalder, Brigitte</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Genes, brain and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Love, Cameron R.</au><au>Gautam, Sumit</au><au>Lama, Chamala</au><au>Le, Nhu Hoa</au><au>Dauwalder, Brigitte</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Drosophila dopamine 2‐like receptor D2R (Dop2R) is required in the blood brain barrier for male courtship</atitle><jtitle>Genes, brain and behavior</jtitle><addtitle>Genes Brain Behav</addtitle><date>2023-02</date><risdate>2023</risdate><volume>22</volume><issue>1</issue><spage>e12836</spage><epage>n/a</epage><pages>e12836-n/a</pages><issn>1601-1848</issn><eissn>1601-183X</eissn><abstract>The blood brain barrier (BBB) has the essential function to protect the brain from potentially hazardous molecules while also enabling controlled selective uptake. 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| subjects | Animals Behavior Blood-brain barrier Blood-Brain Barrier - metabolism Courtship Dopamine Dopamine - metabolism Dopamine D2 receptors Drosophila Drosophila - physiology Drosophila melanogaster - genetics Drosophila Proteins - genetics Drosophila Proteins - metabolism Experiments glia Glial cells Insects Male Males Mating behavior Original Parkinson's disease Proteins Schizophrenia Sexual Behavior, Animal - physiology Variance analysis |
| title | The Drosophila dopamine 2‐like receptor D2R (Dop2R) is required in the blood brain barrier for male courtship |
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