It's a small world for parasites: evidence supporting the North American invasion of European Echinococcus multilocularis
( ), the causative agent of human alveolar echinococcosis (AE), is present in the Holarctic region, and several genetic variants deem to have differential infectivity and pathogenicity. An unprecedented outbreak of human AE cases in Western Canada infected with a European-like strain circulating in...
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| Veröffentlicht in: | Proceedings of the Royal Society. B, Biological sciences Biological sciences, 2023-03, Vol.290 (1994), p.20230128-20230128 |
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| container_end_page | 20230128 |
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| container_issue | 1994 |
| container_start_page | 20230128 |
| container_title | Proceedings of the Royal Society. B, Biological sciences |
| container_volume | 290 |
| creator | Santa, Maria A Umhang, Gerald Klein, Claudia Grant, Danielle M Ruckstuhl, Kathreen E Musiani, Marco Gilleard, John S Massolo, Alessandro |
| description | (
), the causative agent of human alveolar echinococcosis (AE), is present in the Holarctic region, and several genetic variants deem to have differential infectivity and pathogenicity. An unprecedented outbreak of human AE cases in Western Canada infected with a European-like strain circulating in wild hosts warranted assessment of whether this strain was derived from a recent invasion or was endemic but undetected. Using nuclear and mitochondrial markers, we investigated the genetic diversity of
in wild coyotes and red foxes from Western Canada, compared the genetic variants identified to global isolates and assessed their spatial distribution to infer possible invasion dynamics. Genetic variants from Western Canada were closely related to the original European clade, with lesser genetic diversity than that expected for a long-established strain and spatial genetic discontinuities within the study area, supporting the hypothesis of a relatively recent invasion with various founder events. |
| doi_str_mv | 10.1098/rspb.2023.0128 |
| format | Article |
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), the causative agent of human alveolar echinococcosis (AE), is present in the Holarctic region, and several genetic variants deem to have differential infectivity and pathogenicity. An unprecedented outbreak of human AE cases in Western Canada infected with a European-like strain circulating in wild hosts warranted assessment of whether this strain was derived from a recent invasion or was endemic but undetected. Using nuclear and mitochondrial markers, we investigated the genetic diversity of
in wild coyotes and red foxes from Western Canada, compared the genetic variants identified to global isolates and assessed their spatial distribution to infer possible invasion dynamics. Genetic variants from Western Canada were closely related to the original European clade, with lesser genetic diversity than that expected for a long-established strain and spatial genetic discontinuities within the study area, supporting the hypothesis of a relatively recent invasion with various founder events.</description><identifier>ISSN: 0962-8452</identifier><identifier>EISSN: 1471-2954</identifier><identifier>DOI: 10.1098/rspb.2023.0128</identifier><identifier>PMID: 36883278</identifier><language>eng</language><publisher>England: Royal Society, The</publisher><subject>Animals ; Canada ; Echinococcosis ; Echinococcosis - epidemiology ; Echinococcosis - veterinary ; Echinococcus multilocularis - genetics ; Ecology ; Foxes ; Humans ; Life Sciences ; Microbiology and Parasitology ; Parasites ; Parasitology</subject><ispartof>Proceedings of the Royal Society. B, Biological sciences, 2023-03, Vol.290 (1994), p.20230128-20230128</ispartof><rights>Attribution</rights><rights>2023 The Authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c575t-1de435009710f67fe6dd0f2c6cb3caf514b435cd517724dbf48eb7165947f27e3</citedby><cites>FETCH-LOGICAL-c575t-1de435009710f67fe6dd0f2c6cb3caf514b435cd517724dbf48eb7165947f27e3</cites><orcidid>0000-0002-6333-4281 ; 0000-0003-2512-1573 ; 0000-0001-6944-7474</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9993045/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9993045/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36883278$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://anses.hal.science/anses-04127178$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Santa, Maria A</creatorcontrib><creatorcontrib>Umhang, Gerald</creatorcontrib><creatorcontrib>Klein, Claudia</creatorcontrib><creatorcontrib>Grant, Danielle M</creatorcontrib><creatorcontrib>Ruckstuhl, Kathreen E</creatorcontrib><creatorcontrib>Musiani, Marco</creatorcontrib><creatorcontrib>Gilleard, John S</creatorcontrib><creatorcontrib>Massolo, Alessandro</creatorcontrib><title>It's a small world for parasites: evidence supporting the North American invasion of European Echinococcus multilocularis</title><title>Proceedings of the Royal Society. B, Biological sciences</title><addtitle>Proc Biol Sci</addtitle><description>(
), the causative agent of human alveolar echinococcosis (AE), is present in the Holarctic region, and several genetic variants deem to have differential infectivity and pathogenicity. An unprecedented outbreak of human AE cases in Western Canada infected with a European-like strain circulating in wild hosts warranted assessment of whether this strain was derived from a recent invasion or was endemic but undetected. Using nuclear and mitochondrial markers, we investigated the genetic diversity of
in wild coyotes and red foxes from Western Canada, compared the genetic variants identified to global isolates and assessed their spatial distribution to infer possible invasion dynamics. Genetic variants from Western Canada were closely related to the original European clade, with lesser genetic diversity than that expected for a long-established strain and spatial genetic discontinuities within the study area, supporting the hypothesis of a relatively recent invasion with various founder events.</description><subject>Animals</subject><subject>Canada</subject><subject>Echinococcosis</subject><subject>Echinococcosis - epidemiology</subject><subject>Echinococcosis - veterinary</subject><subject>Echinococcus multilocularis - genetics</subject><subject>Ecology</subject><subject>Foxes</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Microbiology and Parasitology</subject><subject>Parasites</subject><subject>Parasitology</subject><issn>0962-8452</issn><issn>1471-2954</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc2PFCEQxYnRuOPq1aPhponpkc-m8bDJZDO6m0z0omdC07CNoaGF7jH738tk1o16okK99wrqB8BrjLYYye5DLnO_JYjQLcKkewI2mAncEMnZU7BBsiVNxzi5AC9K-YEQkrzjz8EFbbuOEtFtwP3t8rZADcukQ4C_Ug4DdCnDWWdd_GLLR2iPfrDRWFjWeU558fEOLqOFX2o9wt1kszc6Qh-P1ZEiTA7u15xmWy_3ZvQxmWTMWuC0hsWHZNagsy8vwTOnQ7GvHs5L8P3T_tv1TXP4-vn2endoDBd8afBgGeX15QIj1wpn22FAjpjW9NRoxzHra98MHAtB2NA71tle4JZLJhwRll6Cq3PuvPaTHYyNS9ZBzdlPOt-rpL36txP9qO7SUUkpKWK8Brw_B4z_2W52B6VjsUUhhonAojviqn73MC6nn6sti5p8MTYEHW1ai6pb51gKSVmVbs9Sk1Mp2brHdIzUia460VUnuupEtxre_P2VR_kfnPQ3UYyj5g</recordid><startdate>20230308</startdate><enddate>20230308</enddate><creator>Santa, Maria A</creator><creator>Umhang, Gerald</creator><creator>Klein, Claudia</creator><creator>Grant, Danielle M</creator><creator>Ruckstuhl, Kathreen E</creator><creator>Musiani, Marco</creator><creator>Gilleard, John S</creator><creator>Massolo, Alessandro</creator><general>Royal Society, The</general><general>The Royal Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6333-4281</orcidid><orcidid>https://orcid.org/0000-0003-2512-1573</orcidid><orcidid>https://orcid.org/0000-0001-6944-7474</orcidid></search><sort><creationdate>20230308</creationdate><title>It's a small world for parasites: evidence supporting the North American invasion of European Echinococcus multilocularis</title><author>Santa, Maria A ; Umhang, Gerald ; Klein, Claudia ; Grant, Danielle M ; Ruckstuhl, Kathreen E ; Musiani, Marco ; Gilleard, John S ; Massolo, Alessandro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c575t-1de435009710f67fe6dd0f2c6cb3caf514b435cd517724dbf48eb7165947f27e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Animals</topic><topic>Canada</topic><topic>Echinococcosis</topic><topic>Echinococcosis - epidemiology</topic><topic>Echinococcosis - veterinary</topic><topic>Echinococcus multilocularis - genetics</topic><topic>Ecology</topic><topic>Foxes</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Microbiology and Parasitology</topic><topic>Parasites</topic><topic>Parasitology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Santa, Maria A</creatorcontrib><creatorcontrib>Umhang, Gerald</creatorcontrib><creatorcontrib>Klein, Claudia</creatorcontrib><creatorcontrib>Grant, Danielle M</creatorcontrib><creatorcontrib>Ruckstuhl, Kathreen E</creatorcontrib><creatorcontrib>Musiani, Marco</creatorcontrib><creatorcontrib>Gilleard, John S</creatorcontrib><creatorcontrib>Massolo, Alessandro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the Royal Society. B, Biological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Santa, Maria A</au><au>Umhang, Gerald</au><au>Klein, Claudia</au><au>Grant, Danielle M</au><au>Ruckstuhl, Kathreen E</au><au>Musiani, Marco</au><au>Gilleard, John S</au><au>Massolo, Alessandro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>It's a small world for parasites: evidence supporting the North American invasion of European Echinococcus multilocularis</atitle><jtitle>Proceedings of the Royal Society. B, Biological sciences</jtitle><addtitle>Proc Biol Sci</addtitle><date>2023-03-08</date><risdate>2023</risdate><volume>290</volume><issue>1994</issue><spage>20230128</spage><epage>20230128</epage><pages>20230128-20230128</pages><issn>0962-8452</issn><eissn>1471-2954</eissn><abstract>(
), the causative agent of human alveolar echinococcosis (AE), is present in the Holarctic region, and several genetic variants deem to have differential infectivity and pathogenicity. An unprecedented outbreak of human AE cases in Western Canada infected with a European-like strain circulating in wild hosts warranted assessment of whether this strain was derived from a recent invasion or was endemic but undetected. Using nuclear and mitochondrial markers, we investigated the genetic diversity of
in wild coyotes and red foxes from Western Canada, compared the genetic variants identified to global isolates and assessed their spatial distribution to infer possible invasion dynamics. Genetic variants from Western Canada were closely related to the original European clade, with lesser genetic diversity than that expected for a long-established strain and spatial genetic discontinuities within the study area, supporting the hypothesis of a relatively recent invasion with various founder events.</abstract><cop>England</cop><pub>Royal Society, The</pub><pmid>36883278</pmid><doi>10.1098/rspb.2023.0128</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-6333-4281</orcidid><orcidid>https://orcid.org/0000-0003-2512-1573</orcidid><orcidid>https://orcid.org/0000-0001-6944-7474</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Proceedings of the Royal Society. B, Biological sciences, 2023-03, Vol.290 (1994), p.20230128-20230128 |
| issn | 0962-8452 1471-2954 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9993045 |
| source | MEDLINE; PubMed Central |
| subjects | Animals Canada Echinococcosis Echinococcosis - epidemiology Echinococcosis - veterinary Echinococcus multilocularis - genetics Ecology Foxes Humans Life Sciences Microbiology and Parasitology Parasites Parasitology |
| title | It's a small world for parasites: evidence supporting the North American invasion of European Echinococcus multilocularis |
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