TNFR2 is a potent prognostic biomarker for post-transplant lung metastasis in patients with hepatocellular carcinoma
Lung metastasis is a common and fatal complication of liver transplantation for hepatocellular carcinoma (HCC). The precise prediction of post-transplant lung metastasis in the early phase is of great value. The mRNA profiles of primary and paired lung metastatic lesions were analyzed to determine k...
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| Veröffentlicht in: | Chinese journal of cancer research 2023-02, Vol.35 (1), p.66-80 |
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| creator | Li, Huigang Lin, Zuyuan Zhuo, Jianyong Yang, Modan Shen, Wei Hu, Zhihang Ding, Yichen Chen, Hao He, Chiyu Yang, Xinyu Dong, Siyi Wei, Xuyong Sun, Beicheng Zheng, Shusen Lang, Ren Lu, Di Xu, Xiao |
| description | Lung metastasis is a common and fatal complication of liver transplantation for hepatocellular carcinoma (HCC). The precise prediction of post-transplant lung metastasis in the early phase is of great value.
The mRNA profiles of primary and paired lung metastatic lesions were analyzed to determine key signaling pathways. We enrolled 241 HCC patients who underwent liver transplantation from three centers. Tissue microarrays were used to evaluate the prognostic capacity of tumor necrosis factor (TNF), tumor necrosis factor receptor 1 (TNFR1), and TNFR2, particularly for post-transplant lung metastasis.
Comparison of primary and lung metastatic lesions revealed that the TNF-dependent signaling pathway was related to lung metastasis of HCC. The expression of TNF was degraded in comparison to that in para-tumor tissues (P |
| doi_str_mv | 10.21147/j.issn.1000-9604.2023.01.07 |
| format | Article |
| fullrecord | <record><control><sourceid>wanfang_jour_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9992998</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><wanfj_id>zgazyj202301007</wanfj_id><sourcerecordid>zgazyj202301007</sourcerecordid><originalsourceid>FETCH-LOGICAL-c394t-b3dc098ac718b8bd9ec89daeaf0ec7f01aa2a955306657f3334c5397bfc51c633</originalsourceid><addsrcrecordid>eNpVUV1rFTEQDaL0y_4FyYOgL7udbPYrIEIptgpFQepzmM3N7s26N1mTrKX99WZ721IhkAxzcs6ZOYS8Z5AXjJXN2ZibEGzOACATNZR5AQXPgeXQvCJHTAieQc3Z6_R-ghyS4xBGgKqpgB2QQ14LBm1VHJF48_3yZ0FNoEhnF7WNdPZusC5Eo2hn3A79b-1p73zqh5hFjzbMEybgtNiB7nTEkE5iMJbOGE3iCPTWxC3d6lQ7padpmdBThV4Zmxjfkjc9TkGfPt4n5Nfll5uLr9n1j6tvF-fXmeKijFnHNwpEi6phbdd2G6FVKzaosQetmh4YYoGiqjjUddX0nPNSVVw0Xa8qpmrOT8jnPe-8dDu9UcmZx0nO3qSp7qRDI__vWLOVg_srhRCFEG0i-LAnuEXbox3k6BZvk2V5P-D93bhuHtKWm4T8-Cjl3Z9Fhyh3JqyTo9VuCbJo2rpiHIoyQT_tocq7ELzunw0xkA8Ry1GuEcs1P7nmJ1chCUw-KL17OdTz56dM-T94EahP</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2786513024</pqid></control><display><type>article</type><title>TNFR2 is a potent prognostic biomarker for post-transplant lung metastasis in patients with hepatocellular carcinoma</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Li, Huigang ; Lin, Zuyuan ; Zhuo, Jianyong ; Yang, Modan ; Shen, Wei ; Hu, Zhihang ; Ding, Yichen ; Chen, Hao ; He, Chiyu ; Yang, Xinyu ; Dong, Siyi ; Wei, Xuyong ; Sun, Beicheng ; Zheng, Shusen ; Lang, Ren ; Lu, Di ; Xu, Xiao</creator><creatorcontrib>Li, Huigang ; Lin, Zuyuan ; Zhuo, Jianyong ; Yang, Modan ; Shen, Wei ; Hu, Zhihang ; Ding, Yichen ; Chen, Hao ; He, Chiyu ; Yang, Xinyu ; Dong, Siyi ; Wei, Xuyong ; Sun, Beicheng ; Zheng, Shusen ; Lang, Ren ; Lu, Di ; Xu, Xiao ; Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China ; Department of Hepatobiliary Surgery, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing 100020, China ; Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China ; Department of Hepatobiliary and Pancreatic Surgery, Shulan (Hangzhou) Hospital, Hangzhou 311112, China ; NHC Key Laboratory of Combined Multi-organ Transplantation, Hangzhou 310003, China ; Institute of Organ Transplantation, Zhejiang University, Hangzhou 310003, China ; Zhejiang University School of Medicine, Hangzhou 310058, China ; Department of Hepatobiliary Surgery, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China ; The Institute for Organ Repair and Regenerative Medicine of Hangzhou, Hangzhou 310006, China ; National Center for Healthcare Quality Management in Liver Transplant, Hangzhou 310003, China</creatorcontrib><description>Lung metastasis is a common and fatal complication of liver transplantation for hepatocellular carcinoma (HCC). The precise prediction of post-transplant lung metastasis in the early phase is of great value.
The mRNA profiles of primary and paired lung metastatic lesions were analyzed to determine key signaling pathways. We enrolled 241 HCC patients who underwent liver transplantation from three centers. Tissue microarrays were used to evaluate the prognostic capacity of tumor necrosis factor (TNF), tumor necrosis factor receptor 1 (TNFR1), and TNFR2, particularly for post-transplant lung metastasis.
Comparison of primary and lung metastatic lesions revealed that the TNF-dependent signaling pathway was related to lung metastasis of HCC. The expression of TNF was degraded in comparison to that in para-tumor tissues (P<0.001). The expression of key receptors in the TNF-dependent signaling pathway, TNFR1 and TNFR2, was higher in HCC tissues than in para-tumor tissues (P<0.001). TNF and TNFR1 showed no relationship with patients' outcomes, whereas elevated TNFR2 in tumor tissue was significantly associated with worse overall survival (OS) and increased recurrence risk (5-year OS rate: 31.9%
62.5%, P<0.001). Notably, elevated TNFR2 levels were also associated with an increased risk of post-transplant lung metastasis (hazard ratio: 1.146; P<0.001). Cox regression analysis revealed that TNFR2, Hangzhou criteria, age, and hepatitis B surface antigen were independent risk factors for post-transplant lung metastasis, and a novel nomogram was established accordingly. The nomogram achieved excellent prognostic efficiency (area under time-dependent receiver operating characteristic =0.755, concordance-index =0.779) and was superior to conventional models, such as the Milan criteria.
TNFR2 is a potent prognostic biomarker for predicting post-transplant lung metastasis in patients with HCC. A nomogram incorporating TNFR2 deserves to be a helpful prognostic tool in liver transplantation for HCC.</description><identifier>ISSN: 1000-9604</identifier><identifier>EISSN: 1993-0631</identifier><identifier>DOI: 10.21147/j.issn.1000-9604.2023.01.07</identifier><identifier>PMID: 36910852</identifier><language>eng</language><publisher>China: Zhejiang University School of Medicine,Hangzhou 310058,China</publisher><subject>Original</subject><ispartof>Chinese journal of cancer research, 2023-02, Vol.35 (1), p.66-80</ispartof><rights>Copyright ©2023 Chinese Journal of Cancer Research. All rights reserved.</rights><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c394t-b3dc098ac718b8bd9ec89daeaf0ec7f01aa2a955306657f3334c5397bfc51c633</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.wanfangdata.com.cn/images/PeriodicalImages/zgazyj/zgazyj.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9992998/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9992998/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36910852$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Huigang</creatorcontrib><creatorcontrib>Lin, Zuyuan</creatorcontrib><creatorcontrib>Zhuo, Jianyong</creatorcontrib><creatorcontrib>Yang, Modan</creatorcontrib><creatorcontrib>Shen, Wei</creatorcontrib><creatorcontrib>Hu, Zhihang</creatorcontrib><creatorcontrib>Ding, Yichen</creatorcontrib><creatorcontrib>Chen, Hao</creatorcontrib><creatorcontrib>He, Chiyu</creatorcontrib><creatorcontrib>Yang, Xinyu</creatorcontrib><creatorcontrib>Dong, Siyi</creatorcontrib><creatorcontrib>Wei, Xuyong</creatorcontrib><creatorcontrib>Sun, Beicheng</creatorcontrib><creatorcontrib>Zheng, Shusen</creatorcontrib><creatorcontrib>Lang, Ren</creatorcontrib><creatorcontrib>Lu, Di</creatorcontrib><creatorcontrib>Xu, Xiao</creatorcontrib><creatorcontrib>Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China</creatorcontrib><creatorcontrib>Department of Hepatobiliary Surgery, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing 100020, China</creatorcontrib><creatorcontrib>Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China</creatorcontrib><creatorcontrib>Department of Hepatobiliary and Pancreatic Surgery, Shulan (Hangzhou) Hospital, Hangzhou 311112, China</creatorcontrib><creatorcontrib>NHC Key Laboratory of Combined Multi-organ Transplantation, Hangzhou 310003, China</creatorcontrib><creatorcontrib>Institute of Organ Transplantation, Zhejiang University, Hangzhou 310003, China</creatorcontrib><creatorcontrib>Zhejiang University School of Medicine, Hangzhou 310058, China</creatorcontrib><creatorcontrib>Department of Hepatobiliary Surgery, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China</creatorcontrib><creatorcontrib>The Institute for Organ Repair and Regenerative Medicine of Hangzhou, Hangzhou 310006, China</creatorcontrib><creatorcontrib>National Center for Healthcare Quality Management in Liver Transplant, Hangzhou 310003, China</creatorcontrib><title>TNFR2 is a potent prognostic biomarker for post-transplant lung metastasis in patients with hepatocellular carcinoma</title><title>Chinese journal of cancer research</title><addtitle>Chin J Cancer Res</addtitle><description>Lung metastasis is a common and fatal complication of liver transplantation for hepatocellular carcinoma (HCC). The precise prediction of post-transplant lung metastasis in the early phase is of great value.
The mRNA profiles of primary and paired lung metastatic lesions were analyzed to determine key signaling pathways. We enrolled 241 HCC patients who underwent liver transplantation from three centers. Tissue microarrays were used to evaluate the prognostic capacity of tumor necrosis factor (TNF), tumor necrosis factor receptor 1 (TNFR1), and TNFR2, particularly for post-transplant lung metastasis.
Comparison of primary and lung metastatic lesions revealed that the TNF-dependent signaling pathway was related to lung metastasis of HCC. The expression of TNF was degraded in comparison to that in para-tumor tissues (P<0.001). The expression of key receptors in the TNF-dependent signaling pathway, TNFR1 and TNFR2, was higher in HCC tissues than in para-tumor tissues (P<0.001). TNF and TNFR1 showed no relationship with patients' outcomes, whereas elevated TNFR2 in tumor tissue was significantly associated with worse overall survival (OS) and increased recurrence risk (5-year OS rate: 31.9%
62.5%, P<0.001). Notably, elevated TNFR2 levels were also associated with an increased risk of post-transplant lung metastasis (hazard ratio: 1.146; P<0.001). Cox regression analysis revealed that TNFR2, Hangzhou criteria, age, and hepatitis B surface antigen were independent risk factors for post-transplant lung metastasis, and a novel nomogram was established accordingly. The nomogram achieved excellent prognostic efficiency (area under time-dependent receiver operating characteristic =0.755, concordance-index =0.779) and was superior to conventional models, such as the Milan criteria.
TNFR2 is a potent prognostic biomarker for predicting post-transplant lung metastasis in patients with HCC. A nomogram incorporating TNFR2 deserves to be a helpful prognostic tool in liver transplantation for HCC.</description><subject>Original</subject><issn>1000-9604</issn><issn>1993-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpVUV1rFTEQDaL0y_4FyYOgL7udbPYrIEIptgpFQepzmM3N7s26N1mTrKX99WZ721IhkAxzcs6ZOYS8Z5AXjJXN2ZibEGzOACATNZR5AQXPgeXQvCJHTAieQc3Z6_R-ghyS4xBGgKqpgB2QQ14LBm1VHJF48_3yZ0FNoEhnF7WNdPZusC5Eo2hn3A79b-1p73zqh5hFjzbMEybgtNiB7nTEkE5iMJbOGE3iCPTWxC3d6lQ7padpmdBThV4Zmxjfkjc9TkGfPt4n5Nfll5uLr9n1j6tvF-fXmeKijFnHNwpEi6phbdd2G6FVKzaosQetmh4YYoGiqjjUddX0nPNSVVw0Xa8qpmrOT8jnPe-8dDu9UcmZx0nO3qSp7qRDI__vWLOVg_srhRCFEG0i-LAnuEXbox3k6BZvk2V5P-D93bhuHtKWm4T8-Cjl3Z9Fhyh3JqyTo9VuCbJo2rpiHIoyQT_tocq7ELzunw0xkA8Ry1GuEcs1P7nmJ1chCUw-KL17OdTz56dM-T94EahP</recordid><startdate>20230228</startdate><enddate>20230228</enddate><creator>Li, Huigang</creator><creator>Lin, Zuyuan</creator><creator>Zhuo, Jianyong</creator><creator>Yang, Modan</creator><creator>Shen, Wei</creator><creator>Hu, Zhihang</creator><creator>Ding, Yichen</creator><creator>Chen, Hao</creator><creator>He, Chiyu</creator><creator>Yang, Xinyu</creator><creator>Dong, Siyi</creator><creator>Wei, Xuyong</creator><creator>Sun, Beicheng</creator><creator>Zheng, Shusen</creator><creator>Lang, Ren</creator><creator>Lu, Di</creator><creator>Xu, Xiao</creator><general>Zhejiang University School of Medicine,Hangzhou 310058,China</general><general>The Institute for Organ Repair and Regenerative Medicine of Hangzhou,Hangzhou 310006,China</general><general>National Center for Healthcare Quality Management in Liver Transplant,Hangzhou 310003,China</general><general>Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province,Department of Hepatobiliary and Pancreatic Surgery,Affiliated Hangzhou First People's Hospital,Zhejiang University School of Medicine,Hangzhou 310006,China</general><general>Department of Hepatobiliary and Pancreatic Surgery,the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China</general><general>Institute of Organ Transplantation,Zhejiang University,Hangzhou 310003,China%Zhejiang University School of Medicine,Hangzhou 310058,China%National Center for Healthcare Quality Management in Liver Transplant,Hangzhou 310003,China%Department of Hepatobiliary Surgery,the Affiliated Drum Tower Hospital of Nanjing University Medical School,Nanjing 210008,China%Institute of Organ Transplantation,Zhejiang University,Hangzhou 310003,China</general><general>Department of Hepatobiliary and Pancreatic Surgery,Shulan(Hangzhou)Hospital,Hangzhou 311112,China</general><general>NHC Key Laboratory of Combined Multi-organ Transplantation,Hangzhou 310003,China%Department of Hepatobiliary Surgery,Beijing Chaoyang Hospital Affiliated to Capital Medical University,Beijing 100020,China%Zhejiang University School of Medicine,Hangzhou 310058,China</general><general>Institute of Organ Transplantation,Zhejiang University,Hangzhou 310003,China</general><general>AME Publishing Company</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>5PM</scope></search><sort><creationdate>20230228</creationdate><title>TNFR2 is a potent prognostic biomarker for post-transplant lung metastasis in patients with hepatocellular carcinoma</title><author>Li, Huigang ; Lin, Zuyuan ; Zhuo, Jianyong ; Yang, Modan ; Shen, Wei ; Hu, Zhihang ; Ding, Yichen ; Chen, Hao ; He, Chiyu ; Yang, Xinyu ; Dong, Siyi ; Wei, Xuyong ; Sun, Beicheng ; Zheng, Shusen ; Lang, Ren ; Lu, Di ; Xu, Xiao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c394t-b3dc098ac718b8bd9ec89daeaf0ec7f01aa2a955306657f3334c5397bfc51c633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Original</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Huigang</creatorcontrib><creatorcontrib>Lin, Zuyuan</creatorcontrib><creatorcontrib>Zhuo, Jianyong</creatorcontrib><creatorcontrib>Yang, Modan</creatorcontrib><creatorcontrib>Shen, Wei</creatorcontrib><creatorcontrib>Hu, Zhihang</creatorcontrib><creatorcontrib>Ding, Yichen</creatorcontrib><creatorcontrib>Chen, Hao</creatorcontrib><creatorcontrib>He, Chiyu</creatorcontrib><creatorcontrib>Yang, Xinyu</creatorcontrib><creatorcontrib>Dong, Siyi</creatorcontrib><creatorcontrib>Wei, Xuyong</creatorcontrib><creatorcontrib>Sun, Beicheng</creatorcontrib><creatorcontrib>Zheng, Shusen</creatorcontrib><creatorcontrib>Lang, Ren</creatorcontrib><creatorcontrib>Lu, Di</creatorcontrib><creatorcontrib>Xu, Xiao</creatorcontrib><creatorcontrib>Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China</creatorcontrib><creatorcontrib>Department of Hepatobiliary Surgery, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing 100020, China</creatorcontrib><creatorcontrib>Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China</creatorcontrib><creatorcontrib>Department of Hepatobiliary and Pancreatic Surgery, Shulan (Hangzhou) Hospital, Hangzhou 311112, China</creatorcontrib><creatorcontrib>NHC Key Laboratory of Combined Multi-organ Transplantation, Hangzhou 310003, China</creatorcontrib><creatorcontrib>Institute of Organ Transplantation, Zhejiang University, Hangzhou 310003, China</creatorcontrib><creatorcontrib>Zhejiang University School of Medicine, Hangzhou 310058, China</creatorcontrib><creatorcontrib>Department of Hepatobiliary Surgery, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China</creatorcontrib><creatorcontrib>The Institute for Organ Repair and Regenerative Medicine of Hangzhou, Hangzhou 310006, China</creatorcontrib><creatorcontrib>National Center for Healthcare Quality Management in Liver Transplant, Hangzhou 310003, China</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Chinese journal of cancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Huigang</au><au>Lin, Zuyuan</au><au>Zhuo, Jianyong</au><au>Yang, Modan</au><au>Shen, Wei</au><au>Hu, Zhihang</au><au>Ding, Yichen</au><au>Chen, Hao</au><au>He, Chiyu</au><au>Yang, Xinyu</au><au>Dong, Siyi</au><au>Wei, Xuyong</au><au>Sun, Beicheng</au><au>Zheng, Shusen</au><au>Lang, Ren</au><au>Lu, Di</au><au>Xu, Xiao</au><aucorp>Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China</aucorp><aucorp>Department of Hepatobiliary Surgery, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing 100020, China</aucorp><aucorp>Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China</aucorp><aucorp>Department of Hepatobiliary and Pancreatic Surgery, Shulan (Hangzhou) Hospital, Hangzhou 311112, China</aucorp><aucorp>NHC Key Laboratory of Combined Multi-organ Transplantation, Hangzhou 310003, China</aucorp><aucorp>Institute of Organ Transplantation, Zhejiang University, Hangzhou 310003, China</aucorp><aucorp>Zhejiang University School of Medicine, Hangzhou 310058, China</aucorp><aucorp>Department of Hepatobiliary Surgery, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China</aucorp><aucorp>The Institute for Organ Repair and Regenerative Medicine of Hangzhou, Hangzhou 310006, China</aucorp><aucorp>National Center for Healthcare Quality Management in Liver Transplant, Hangzhou 310003, China</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>TNFR2 is a potent prognostic biomarker for post-transplant lung metastasis in patients with hepatocellular carcinoma</atitle><jtitle>Chinese journal of cancer research</jtitle><addtitle>Chin J Cancer Res</addtitle><date>2023-02-28</date><risdate>2023</risdate><volume>35</volume><issue>1</issue><spage>66</spage><epage>80</epage><pages>66-80</pages><issn>1000-9604</issn><eissn>1993-0631</eissn><abstract>Lung metastasis is a common and fatal complication of liver transplantation for hepatocellular carcinoma (HCC). The precise prediction of post-transplant lung metastasis in the early phase is of great value.
The mRNA profiles of primary and paired lung metastatic lesions were analyzed to determine key signaling pathways. We enrolled 241 HCC patients who underwent liver transplantation from three centers. Tissue microarrays were used to evaluate the prognostic capacity of tumor necrosis factor (TNF), tumor necrosis factor receptor 1 (TNFR1), and TNFR2, particularly for post-transplant lung metastasis.
Comparison of primary and lung metastatic lesions revealed that the TNF-dependent signaling pathway was related to lung metastasis of HCC. The expression of TNF was degraded in comparison to that in para-tumor tissues (P<0.001). The expression of key receptors in the TNF-dependent signaling pathway, TNFR1 and TNFR2, was higher in HCC tissues than in para-tumor tissues (P<0.001). TNF and TNFR1 showed no relationship with patients' outcomes, whereas elevated TNFR2 in tumor tissue was significantly associated with worse overall survival (OS) and increased recurrence risk (5-year OS rate: 31.9%
62.5%, P<0.001). Notably, elevated TNFR2 levels were also associated with an increased risk of post-transplant lung metastasis (hazard ratio: 1.146; P<0.001). Cox regression analysis revealed that TNFR2, Hangzhou criteria, age, and hepatitis B surface antigen were independent risk factors for post-transplant lung metastasis, and a novel nomogram was established accordingly. The nomogram achieved excellent prognostic efficiency (area under time-dependent receiver operating characteristic =0.755, concordance-index =0.779) and was superior to conventional models, such as the Milan criteria.
TNFR2 is a potent prognostic biomarker for predicting post-transplant lung metastasis in patients with HCC. A nomogram incorporating TNFR2 deserves to be a helpful prognostic tool in liver transplantation for HCC.</abstract><cop>China</cop><pub>Zhejiang University School of Medicine,Hangzhou 310058,China</pub><pmid>36910852</pmid><doi>10.21147/j.issn.1000-9604.2023.01.07</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Chinese journal of cancer research, 2023-02, Vol.35 (1), p.66-80 |
| issn | 1000-9604 1993-0631 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9992998 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Original |
| title | TNFR2 is a potent prognostic biomarker for post-transplant lung metastasis in patients with hepatocellular carcinoma |
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