Structural basis of antifolate recognition and transport by PCFT

Folates (also known as vitamin B9) have a critical role in cellular metabolism as the starting point in the synthesis of nucleic acids, amino acids and the universal methylating agent S -adenylsmethionine 1 , 2 . Folate deficiency is associated with a number of developmental, immune and neurological...

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Veröffentlicht in:	Nature (London) 2021-07, Vol.595 (7865), p.130-134
Hauptverfasser:	Parker, Joanne L., Deme, Justin C., Kuteyi, Gabriel, Wu, Zhiyi, Huo, Jiandong, Goldman, I. David, Owens, Raymond J., Biggin, Philip C., Lea, Susan M., Newstead, Simon
Format:	Artikel
Sprache:	eng
Schlagworte:	631/535/1258/1259 631/57/2283 631/67/1059/153 Amino acids Antifolate agents Apoproteins - chemistry Apoproteins - metabolism Apoproteins - ultrastructure Binding sites Biological Transport Cancer therapies Cryoelectron Microscopy Drug delivery Drugs Electron microscopy Folic acid Folic Acid Antagonists - chemistry Folic Acid Antagonists - metabolism Humanities and Social Sciences Humans Immunosuppressive agents Ligands Microscopy Models, Molecular multidisciplinary Mutation Nucleic acids Pemetrexed - chemistry Pemetrexed - metabolism Proteins Proton-Coupled Folate Transporter - chemistry Proton-Coupled Folate Transporter - metabolism Proton-Coupled Folate Transporter - ultrastructure Protons Recognition Salt Science Science (multidisciplinary) Substrates Vitamin B Vitamin deficiency
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