Succinate‐GPR‐91 receptor signalling is responsible for nonalcoholic steatohepatitis‐associated fibrosis: Effects of DHA supplementation

Background and aims Treatment of non‐alcoholic steatohepatitis (NASH) is challenging, because suppressing fibrotic progression has not been achieved consistently by drug candidates currently in clinical trials. The aim of this study was to investigate the molecular interplays underlying NASH‐associa...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Liver international 2020-04, Vol.40 (4), p.830-843
Hauptverfasser:	Liu, Xue‐Jing, Xie, Li, Du, Kuo, Liu, Chang, Zhang, Ning‐Ping, Gu, Chen‐Jian, Wang, Ying, Abdelmalek, Manal F., Dong, Wen‐Yue, Liu, Xiu‐Ping, Niu, Chen, Yang, Chen, Diehl, Anna Mae, Wu, Jian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biopsy Clinical trials Dietary Supplements Docosahexaenoic acid Docosahexaenoic Acids - pharmacology Drinking behavior Drinking water Drug development Extracellular matrix Fatty acids Fibrosis Fructose GPR‐91 receptor hepatic stellate cells Hepatocytes High fat diet Histology Liver - pathology Mice Mice, Inbred C57BL Non-alcoholic Fatty Liver Disease - drug therapy Non-alcoholic Fatty Liver Disease - pathology nonalcoholic steatohepatitis Oxidants Oxidizing agents Receptors Signaling Stellate cells succinate Succinate dehydrogenase Succinic Acid
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!