L-type calcium channel antagonist isradipine age-dependently decreases plaque associated dystrophic neurites in 5XFAD mouse model

Epidemiological studies suggest that L-type calcium channel (LTCC) antagonists may reduce the incidence of age-associated neurodegenerative diseases including Alzheimer's disease (AD). However, the neuroprotective mechanism of LTCC antagonists is unknown. Amyloid-β (Aβ) pathology disrupts intra...

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Veröffentlicht in:	Neuropharmacology 2023-04, Vol.227, p.109454-109454, Article 109454
Hauptverfasser:	Wickline, Jessica L., Smith, Sabrina, Shin, Riley, Odfalk, Kristian, Sanchez, Jesse, Javors, Martin, Ginsburg, Brett, Hopp, Sarah C.
Format:	Artikel
Sprache:	eng
Schlagworte:	5XFAD Alzheimer Disease - metabolism Amyloid Amyloid beta-Peptides - metabolism Amyloid beta-Protein Precursor - metabolism Animals Calcium Channel Blockers Calcium Channels, L-Type - metabolism Disease Models, Animal Isradipine Isradipine - metabolism L-type calcium channel Lysosome Mice Mice, Transgenic Microglia Microglia - metabolism Neurites - metabolism Plaque, Amyloid - metabolism
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