Clinical and economic burden of pneumococcal disease among individuals aged 16 years and older in Germany
This study assessed the incidence rate of all-cause pneumonia (ACP) and invasive pneumococcal disease (IPD) and associated medical costs among individuals aged ≥16 in the German InGef database from 2016 to 2019. Incidence rate was expressed as the number of episodes per 100 000 person-years (PY). He...
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| Veröffentlicht in: | Epidemiology and infection 2022-11, Vol.150, p.e204-e204, Article e204 |
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| creator | Deb, Arijita Podmore, Bélène Barnett, Rosemarie Beier, Dominik Galetzka, Wolfgang Qizilbash, Nawab Haeckl, Dennis Mihm, Sarah Johnson, Kelly D. Weiss, Thomas |
| description | This study assessed the incidence rate of all-cause pneumonia (ACP) and invasive pneumococcal disease (IPD) and associated medical costs among individuals aged ≥16 in the German InGef database from 2016 to 2019. Incidence rate was expressed as the number of episodes per 100 000 person-years (PY). Healthcare resource utilisation was investigated by age group and by risk group (healthy, at-risk, high-risk). Direct medical costs per ACP/IPD episode were estimated as the total costs of all inpatient and outpatient visits. The overall incidence rate of ACP was 1345 (95% CI 1339–1352) and 8.25 (95% CI 7.76–8.77) per 100 000 PY for IPD. For both ACP and IPD, incidence rates increased with age and were higher in the high-risk and at-risk groups, in comparison to the healthy group. ACP inpatient admission rate increased with age but remained steady across age-groups for IPD. The mean direct medical costs per episode were €8075 (95% CI 7121–9028) for IPD and €1454 (95% CI 1426–1482) for ACP. The aggregate direct medical costs for IPD and ACP episodes were estimated to be €8.5 million and €248.9 million respectively. The clinical and economic burden of IPD and ACP among German adults is substantial regardless of age. |
| doi_str_mv | 10.1017/S0950268822001182 |
| format | Article |
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Incidence rate was expressed as the number of episodes per 100 000 person-years (PY). Healthcare resource utilisation was investigated by age group and by risk group (healthy, at-risk, high-risk). Direct medical costs per ACP/IPD episode were estimated as the total costs of all inpatient and outpatient visits. The overall incidence rate of ACP was 1345 (95% CI 1339–1352) and 8.25 (95% CI 7.76–8.77) per 100 000 PY for IPD. For both ACP and IPD, incidence rates increased with age and were higher in the high-risk and at-risk groups, in comparison to the healthy group. ACP inpatient admission rate increased with age but remained steady across age-groups for IPD. The mean direct medical costs per episode were €8075 (95% CI 7121–9028) for IPD and €1454 (95% CI 1426–1482) for ACP. The aggregate direct medical costs for IPD and ACP episodes were estimated to be €8.5 million and €248.9 million respectively. The clinical and economic burden of IPD and ACP among German adults is substantial regardless of age.</description><identifier>ISSN: 0950-2688</identifier><identifier>EISSN: 1469-4409</identifier><identifier>DOI: 10.1017/S0950268822001182</identifier><identifier>PMID: 36345842</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adult ; Age ; Chronic illnesses ; Codes ; Congenital diseases ; Costs ; Costs and Cost Analysis ; Economics ; Hospitals ; Humans ; Incidence ; Infections ; Lung diseases ; Medical research ; Meningitis ; Mortality ; Older people ; Original Paper ; Pneumococcal Infections - epidemiology ; Pneumococcal Vaccines ; Pneumonia ; Pneumonia - complications ; Population ; Risk ; Risk Factors ; Risk groups ; Streptococcus infections ; Transplants & implants ; Vaccines</subject><ispartof>Epidemiology and infection, 2022-11, Vol.150, p.e204-e204, Article e204</ispartof><rights>Copyright © Merck & Co., Inc., Rahway, NJ, USA and its affiliates and the Author(s), 2022. Published by Cambridge University Press</rights><rights>Copyright © Merck & Co., Inc., Rahway, NJ, USA and its affiliates and the Author(s), 2022. Published by Cambridge University Press. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Cambridge University Press 2022 2022 Cambridge University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c498t-d58ca536878cce8929857ab5028c57cbe72166ca717921aab564a4609eadeb6f3</citedby><cites>FETCH-LOGICAL-c498t-d58ca536878cce8929857ab5028c57cbe72166ca717921aab564a4609eadeb6f3</cites><orcidid>0000-0002-2215-4970</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9987016/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0950268822001182/type/journal_article$$EHTML$$P50$$Gcambridge$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,23323,27929,27930,53796,53798,55809</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36345842$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Deb, Arijita</creatorcontrib><creatorcontrib>Podmore, Bélène</creatorcontrib><creatorcontrib>Barnett, Rosemarie</creatorcontrib><creatorcontrib>Beier, Dominik</creatorcontrib><creatorcontrib>Galetzka, Wolfgang</creatorcontrib><creatorcontrib>Qizilbash, Nawab</creatorcontrib><creatorcontrib>Haeckl, Dennis</creatorcontrib><creatorcontrib>Mihm, Sarah</creatorcontrib><creatorcontrib>Johnson, Kelly D.</creatorcontrib><creatorcontrib>Weiss, Thomas</creatorcontrib><title>Clinical and economic burden of pneumococcal disease among individuals aged 16 years and older in Germany</title><title>Epidemiology and infection</title><addtitle>Epidemiol. Infect</addtitle><description>This study assessed the incidence rate of all-cause pneumonia (ACP) and invasive pneumococcal disease (IPD) and associated medical costs among individuals aged ≥16 in the German InGef database from 2016 to 2019. Incidence rate was expressed as the number of episodes per 100 000 person-years (PY). Healthcare resource utilisation was investigated by age group and by risk group (healthy, at-risk, high-risk). Direct medical costs per ACP/IPD episode were estimated as the total costs of all inpatient and outpatient visits. The overall incidence rate of ACP was 1345 (95% CI 1339–1352) and 8.25 (95% CI 7.76–8.77) per 100 000 PY for IPD. For both ACP and IPD, incidence rates increased with age and were higher in the high-risk and at-risk groups, in comparison to the healthy group. ACP inpatient admission rate increased with age but remained steady across age-groups for IPD. The mean direct medical costs per episode were €8075 (95% CI 7121–9028) for IPD and €1454 (95% CI 1426–1482) for ACP. The aggregate direct medical costs for IPD and ACP episodes were estimated to be €8.5 million and €248.9 million respectively. 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Epidemiology and infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Deb, Arijita</au><au>Podmore, Bélène</au><au>Barnett, Rosemarie</au><au>Beier, Dominik</au><au>Galetzka, Wolfgang</au><au>Qizilbash, Nawab</au><au>Haeckl, Dennis</au><au>Mihm, Sarah</au><au>Johnson, Kelly D.</au><au>Weiss, Thomas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical and economic burden of pneumococcal disease among individuals aged 16 years and older in Germany</atitle><jtitle>Epidemiology and infection</jtitle><addtitle>Epidemiol. Infect</addtitle><date>2022-11-08</date><risdate>2022</risdate><volume>150</volume><spage>e204</spage><epage>e204</epage><pages>e204-e204</pages><artnum>e204</artnum><issn>0950-2688</issn><eissn>1469-4409</eissn><abstract>This study assessed the incidence rate of all-cause pneumonia (ACP) and invasive pneumococcal disease (IPD) and associated medical costs among individuals aged ≥16 in the German InGef database from 2016 to 2019. Incidence rate was expressed as the number of episodes per 100 000 person-years (PY). Healthcare resource utilisation was investigated by age group and by risk group (healthy, at-risk, high-risk). Direct medical costs per ACP/IPD episode were estimated as the total costs of all inpatient and outpatient visits. The overall incidence rate of ACP was 1345 (95% CI 1339–1352) and 8.25 (95% CI 7.76–8.77) per 100 000 PY for IPD. For both ACP and IPD, incidence rates increased with age and were higher in the high-risk and at-risk groups, in comparison to the healthy group. ACP inpatient admission rate increased with age but remained steady across age-groups for IPD. The mean direct medical costs per episode were €8075 (95% CI 7121–9028) for IPD and €1454 (95% CI 1426–1482) for ACP. The aggregate direct medical costs for IPD and ACP episodes were estimated to be €8.5 million and €248.9 million respectively. The clinical and economic burden of IPD and ACP among German adults is substantial regardless of age.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>36345842</pmid><doi>10.1017/S0950268822001182</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-2215-4970</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Cambridge Journals Open Access; DOAJ Directory of Open Access Journals; PubMed Central |
| subjects | Adult Age Chronic illnesses Codes Congenital diseases Costs Costs and Cost Analysis Economics Hospitals Humans Incidence Infections Lung diseases Medical research Meningitis Mortality Older people Original Paper Pneumococcal Infections - epidemiology Pneumococcal Vaccines Pneumonia Pneumonia - complications Population Risk Risk Factors Risk groups Streptococcus infections Transplants & implants Vaccines |
| title | Clinical and economic burden of pneumococcal disease among individuals aged 16 years and older in Germany |
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