Estrogen receptor alpha signaling in dendritic cells modulates autoimmune disease phenotype in mice

Estrogen is a disease‐modifying factor in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE) via estrogen receptor alpha (ERα). However, the mechanisms by which ERα signaling contributes to changes in disease pathogenesis have not been completely elucidated....

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Veröffentlicht in:	EMBO reports 2023-03, Vol.24 (3), p.e54228-n/a
Hauptverfasser:	Khaw, Yee Ming, Anwar, Shehata, Zhou, Jinyan, Kawano, Tasuku, Lin, Po‐Ching, Otero, Ashley, Barakat, Radwa, Drnevich, Jenny, Takahashi, Tomoko, Ko, CheMyong Jay, Inoue, Makoto
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Autoimmune diseases CD4 antigen Cell activation Central nervous system Clonal deletion CNS neurodegenerative Dendritic cells Dendritic Cells - metabolism Dendritic structure Disease control Effector cells EMBO19 EMBO24 EMBO37 Encephalomyelitis Encephalomyelitis, Autoimmune, Experimental estrogen Estrogen Receptor alpha - genetics Estrogen Receptor alpha - metabolism Estrogen receptors Estrogens Estrogens - pharmacology Experimental allergic encephalomyelitis extragonadal organ Genotype & phenotype Interferon Interferon regulatory factor 3 Life Sciences Lymph nodes Lymphocytes Lymphocytes T Lymphotoxin Lymphotoxin beta Receptor - genetics Lymphotoxin beta Receptor - metabolism membrane lymphotoxin Membranes Mice Mice, Inbred C57BL Multiple sclerosis Nervous system Neurodegeneration Neurotoxicity Nuclear transport Pathogenesis Phenotype phenotype change Phenotypes Receptors Signaling Signs and symptoms TLR4 protein TNF Receptor-Associated Factor 3 - genetics TNF Receptor-Associated Factor 3 - metabolism Toll-like receptors Translocation Ubiquitination β-Interferon
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