The super elongation complex (SEC) mediates phase transition of SPT5 during transcriptional pause release

Release of promoter‐proximally paused RNA Pol II into elongation is a tightly regulated and rate‐limiting step in metazoan gene transcription. However, the biophysical mechanism underlying pause release remains unclear. Here, we demonstrate that the pausing and elongation regulator SPT5 undergoes ph...

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Veröffentlicht in:	EMBO reports 2023-03, Vol.24 (3), p.e55699-n/a
Hauptverfasser:	Guo, Chenghao, Zhang, Yadi, Shuai, Shimin, Sigbessia, Abire, Hao, Shaohua, Xie, Peng, Jiang, Xu, Luo, Zhuojuan, Lin, Chengqi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Clusters Depletion DNA-directed RNA polymerase Domains Droplets Elongation EMBO09 Life Sciences Mutation paused Pol II phase separation Phase transitions Relocation RNA Polymerase II - metabolism SPT5 super elongation complex (SEC) Transcription elongation Transcription, Genetic Transcriptional Activation Transcriptional Elongation Factors - genetics Transcriptional Elongation Factors - metabolism
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