Shikonin reverses pyruvate kinase isoform M2‐mediated propranolol resistance in infantile hemangioma through reactive oxygen species‐induced autophagic dysfunction

Infantile hemangioma (IH) is the most common benign tumor in infancy. Propranolol, a nonselective β‐adrenergic receptor blocker, is now the first‐line therapy for IH. Recently, low sensitivity to propranolol therapy has become one major reason for the failure of IH treatment. However, the exact unde...

Ausführliche Beschreibung