SMARCA4 biology in alveolar rhabdomyosarcoma

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and phenocopies a muscle precursor that fails to undergo terminal differentiation. The alveolar subtype (ARMS) has the poorest prognosis and represents the greatest unmet medical need for RMS. Emerging evidence supports the ro...

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Veröffentlicht in:	Oncogene 2022-03, Vol.41 (11), p.1647-1656
Hauptverfasser:	Bharathy, Narendra, Cleary, Megan M., Kim, Jin-Ah, Nagamori, Kiyo, Crawford, Kenneth A., Wang, Eric, Saha, Debarya, Settelmeyer, Teagan P., Purohit, Reshma, Skopelitis, Damianos, Chang, Kenneth, Doran, Jessica A., Kirschbaum, C. Ward, Bharathy, Suriya, Crews, Davis W., Randolph, Matthew E., Karnezis, Anthony N., Hudson-Price, Lisa, Dhawan, Jyotsna, Michalek, Joel E., Ciulli, Alessio, Vakoc, Christopher R., Keller, Charles
Format:	Artikel
Sprache:	eng
Schlagworte:	13/89 14/63 45/90 45/91 631/45/475 631/67/2332 64/110 64/60 82/80 96/1 96/109 Alveoli Apoptosis Biology BRG1 protein Cell Biology Cell survival Child Chromatin remodeling CRISPR DNA Helicases - genetics Epigenetics Human Genetics Humans Internal Medicine Medical prognosis Medicine Medicine & Public Health Neoplasms Nuclear Proteins - genetics Oncology Rhabdomyosarcoma Rhabdomyosarcoma, Alveolar - genetics Rhabdomyosarcoma, Embryonal Snf2 protein Soft tissue sarcoma SWI/SNF complex Therapeutic targets Transcription Factors - genetics Tumors
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