Interleukin-18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis

Nucleotide-binding oligomerization domain-like receptor-family pyrin domain-containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis. Mechanisms and downstream signaling remain incompletely understood. Here, we studied the role of IL-18 in hepatic stellate cells (HSCs)...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2023-06, Vol.77 (6), p.1968-1982
Hauptverfasser:	Knorr, Jana, Kaufmann, Benedikt, Inzaugarat, Maria Eugenia, Holtmann, Theresa Maria, Geisler, Lukas, Hundertmark, Jana, Kohlhepp, Marlene Sophia, Boosheri, Laela M, Chilin-Fuentes, Daisy R, Birmingham, Amanda, Fisch, Kathleen M, Schilling, Joel D, Loosen, Sven H, Trautwein, Christian, Roderburg, Christoph, Demir, Münevver, Tacke, Frank, Hoffman, Hal M, Feldstein, Ariel E, Wree, Alexander
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carrier Proteins - metabolism Fibrosis Hepatic Stellate Cells - metabolism Inflammasomes - metabolism Interleukin-18 Liver - pathology Liver Cirrhosis - pathology Mice NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Original : Liver Pathobiology
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