Integrin-KCNB1 potassium channel complexes regulate neocortical neuronal development and are implicated in epilepsy

Potassium (K + ) channels are robustly expressed during prenatal brain development, including in progenitor cells and migrating neurons, but their function is poorly understood. Here, we investigate the role of voltage-gated K + channel KCNB1 (Kv2.1) in neocortical development. Neuronal migration of...

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Veröffentlicht in:	Cell death and differentiation 2023-03, Vol.30 (3), p.687-701
Hauptverfasser:	Bortolami, Alessandro, Yu, Wei, Forzisi, Elena, Ercan, Koray, Kadakia, Ritik, Murugan, Madhuvika, Fedele, Denise, Estevez, Irving, Boison, Detlev, Rasin, Mladen-Roko, Sesti, Federico
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/1 14 631/80/79/1236 64 64/60 692/308/1426 82 96 Angiotensin Angiotensin II Animals Apoptosis Biochemistry Biomedical and Life Sciences Cell Biology Cell Cycle Analysis Cell migration Channel gating Channelopathy Epilepsy Epilepsy - genetics Etiology Focal adhesion kinase Glutamatergic transmission Integrins Integrins - genetics Life Sciences Mice Mice, Knockout Mutation Neocortex Neural networks Neural stem cells Phenotypes Potassium Potassium channels (voltage-gated) Potassium Channels - genetics Progenitor cells Seizures Stem Cells
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