Novel GluN2B-Selective NMDA Receptor Negative Allosteric Modulator Possesses Intrinsic Analgesic Properties and Enhances Analgesia of Morphine in a Rodent Tail Flick Pain Model

Many cases of accidental death associated with drug overdose are due to chronic opioid use, tolerance, and addiction. Analgesic tolerance is characterized by a decreased response to the analgesic effects of opioids, requiring increasingly higher doses to maintain the desired level of pain relief. Ov...

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Veröffentlicht in:	ACS chemical neuroscience 2023-03, Vol.14 (5), p.917-935
Hauptverfasser:	Harris, Lynnea D., Regan, Michael C., Myers, Scott J., Nocilla, Kelsey A., Akins, Nicholas S., Tahirovic, Yesim A., Wilson, Lawrence J., Dingledine, Ray, Furukawa, Hiro, Traynelis, Stephen F., Liotta, Dennis C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesia Analgesics - pharmacology Analgesics - therapeutic use Analgesics, Opioid - pharmacology Analgesics, Opioid - therapeutic use Animals Dose-Response Relationship, Drug Morphine Pain - drug therapy Pain - metabolism Receptors, N-Methyl-D-Aspartate - metabolism Rodentia - metabolism
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