Anti-inflammatory constituents isolated from the flowers of Hosta plantaginea via suppression of the NF-κB signaling pathway in LPS-stimulated RAW 264.7 macrophages
(Lam.) Aschers flower is traditionally used in China as an important herbal medicine for the treatment of inflammatory disease. The present study isolated one new compound, namely (3 )-dihydrobonducellin (1), and five known ones, -hydroxycinnamic acid (2), paprazine (3), thymidine (4), bis(2-ethylhe...
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| creator | He, Jie-Wei Guo, Ping Yang, Li He, Jun-Wei |
| description | (Lam.) Aschers flower is traditionally used in China as an important herbal medicine for the treatment of inflammatory disease. The present study isolated one new compound, namely (3
)-dihydrobonducellin (1), and five known ones,
-hydroxycinnamic acid (2), paprazine (3), thymidine (4), bis(2-ethylhexyl) phthalate (5), and dibutyl phthalate (6) from
flowers. These structures were elucidated from spectroscopic data. Among them, compounds 1-4 remarkably suppressed nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264.7 cells with half maximal inhibitory concentration (IC
) values of 19.88 ± 1.81, 39.80 ± 0.85, 19.03 ± 2.35, and 34.63 ± 2.38 μM, respectively. Furthermore, compounds 1 and 3 (20 μM) significantly decreased levels of tumor necrosis factor α (TNF-α), prostaglandin E2 (PGE2), interleukin 1β (IL-1β), and IL-6. Additionally, compounds 1 and 3 (20 μM) prominently reduced the phosphorylation protein level of nuclear factor kappa-B (NF-κB) p65. The present findings indicated that compounds 1 and 3 may be new candidates against inflammation
blocking the NF-κB signaling pathway. |
| doi_str_mv | 10.1039/d2ra07623c |
| format | Article |
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)-dihydrobonducellin (1), and five known ones,
-hydroxycinnamic acid (2), paprazine (3), thymidine (4), bis(2-ethylhexyl) phthalate (5), and dibutyl phthalate (6) from
flowers. These structures were elucidated from spectroscopic data. Among them, compounds 1-4 remarkably suppressed nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264.7 cells with half maximal inhibitory concentration (IC
) values of 19.88 ± 1.81, 39.80 ± 0.85, 19.03 ± 2.35, and 34.63 ± 2.38 μM, respectively. Furthermore, compounds 1 and 3 (20 μM) significantly decreased levels of tumor necrosis factor α (TNF-α), prostaglandin E2 (PGE2), interleukin 1β (IL-1β), and IL-6. Additionally, compounds 1 and 3 (20 μM) prominently reduced the phosphorylation protein level of nuclear factor kappa-B (NF-κB) p65. The present findings indicated that compounds 1 and 3 may be new candidates against inflammation
blocking the NF-κB signaling pathway.</description><identifier>ISSN: 2046-2069</identifier><identifier>EISSN: 2046-2069</identifier><identifier>DOI: 10.1039/d2ra07623c</identifier><identifier>PMID: 36875879</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Chemistry ; Dibutyl phthalate ; Dioctyl phthalate ; Flowers ; Herbal medicine ; Hydroxycinnamic acid ; Interleukins ; Macrophages ; Nitric oxide ; Phosphorylation ; Signaling ; Thymidine ; Tumor necrosis factor-TNF</subject><ispartof>RSC advances, 2023-03, Vol.13 (11), p.7179-7184</ispartof><rights>This journal is © The Royal Society of Chemistry.</rights><rights>Copyright Royal Society of Chemistry 2023</rights><rights>This journal is © The Royal Society of Chemistry 2023 The Royal Society of Chemistry</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c321c-13a4567512a23ca0c8ed9032adedc34dcf9c6cd8372a15dc8b0ecd32afcebe443</citedby><cites>FETCH-LOGICAL-c321c-13a4567512a23ca0c8ed9032adedc34dcf9c6cd8372a15dc8b0ecd32afcebe443</cites><orcidid>0000-0001-6376-3505</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9982826/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9982826/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36875879$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>He, Jie-Wei</creatorcontrib><creatorcontrib>Guo, Ping</creatorcontrib><creatorcontrib>Yang, Li</creatorcontrib><creatorcontrib>He, Jun-Wei</creatorcontrib><title>Anti-inflammatory constituents isolated from the flowers of Hosta plantaginea via suppression of the NF-κB signaling pathway in LPS-stimulated RAW 264.7 macrophages</title><title>RSC advances</title><addtitle>RSC Adv</addtitle><description>(Lam.) Aschers flower is traditionally used in China as an important herbal medicine for the treatment of inflammatory disease. The present study isolated one new compound, namely (3
)-dihydrobonducellin (1), and five known ones,
-hydroxycinnamic acid (2), paprazine (3), thymidine (4), bis(2-ethylhexyl) phthalate (5), and dibutyl phthalate (6) from
flowers. These structures were elucidated from spectroscopic data. Among them, compounds 1-4 remarkably suppressed nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264.7 cells with half maximal inhibitory concentration (IC
) values of 19.88 ± 1.81, 39.80 ± 0.85, 19.03 ± 2.35, and 34.63 ± 2.38 μM, respectively. Furthermore, compounds 1 and 3 (20 μM) significantly decreased levels of tumor necrosis factor α (TNF-α), prostaglandin E2 (PGE2), interleukin 1β (IL-1β), and IL-6. Additionally, compounds 1 and 3 (20 μM) prominently reduced the phosphorylation protein level of nuclear factor kappa-B (NF-κB) p65. The present findings indicated that compounds 1 and 3 may be new candidates against inflammation
blocking the NF-κB signaling pathway.</description><subject>Chemistry</subject><subject>Dibutyl phthalate</subject><subject>Dioctyl phthalate</subject><subject>Flowers</subject><subject>Herbal medicine</subject><subject>Hydroxycinnamic acid</subject><subject>Interleukins</subject><subject>Macrophages</subject><subject>Nitric oxide</subject><subject>Phosphorylation</subject><subject>Signaling</subject><subject>Thymidine</subject><subject>Tumor necrosis factor-TNF</subject><issn>2046-2069</issn><issn>2046-2069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpdks9u1DAQxi0EolXphQdAlrggpLT-kzjOBWlZKK20AlRAHK1Zx8m6SuxgO632gXgJHoJnwtstVcEXW5rfzDfzeRB6TskJJbw5bVkAUgvG9SN0yEgpCkZE8_jB-wAdx3hF8hEVZYI-RQdcyLqSdXOIfi5csoV13QDjCMmHLdbexWTTbFyK2EY_QDIt7oIfcdoY3A3-xoSIfYfPfUyApwFcgt46A_jaAo7zNAUTo_VuB-1yPp4Vv3-9xdH2DgbrejxB2tzAFluHV5-_FFlvnPc6l4vvmInypMYj6OCnDfQmPkNPOhiiOb67j9C3s_dfl-fF6tOHi-ViVWjOqC4oh7ISdZ4Ssh9AtDRtQziD1rSal63uGi10K3nNgFatlmtidJvjnTZrU5b8CL3Z153m9ZhzsgUBBjUFO0LYKg9W_RtxdqN6f62aRjLJRC7w6q5A8D9mE5MabdRmyBYZP0fF6iwuJW1kRl_-h175OWR_bilBGCOkytTrPZW9iDGY7r4ZStRuAdQ7drm4XYBlhl88bP8e_fvd_A9by6_5</recordid><startdate>20230301</startdate><enddate>20230301</enddate><creator>He, Jie-Wei</creator><creator>Guo, Ping</creator><creator>Yang, Li</creator><creator>He, Jun-Wei</creator><general>Royal Society of Chemistry</general><general>The Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6376-3505</orcidid></search><sort><creationdate>20230301</creationdate><title>Anti-inflammatory constituents isolated from the flowers of Hosta plantaginea via suppression of the NF-κB signaling pathway in LPS-stimulated RAW 264.7 macrophages</title><author>He, Jie-Wei ; Guo, Ping ; Yang, Li ; He, Jun-Wei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c321c-13a4567512a23ca0c8ed9032adedc34dcf9c6cd8372a15dc8b0ecd32afcebe443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Chemistry</topic><topic>Dibutyl phthalate</topic><topic>Dioctyl phthalate</topic><topic>Flowers</topic><topic>Herbal medicine</topic><topic>Hydroxycinnamic acid</topic><topic>Interleukins</topic><topic>Macrophages</topic><topic>Nitric oxide</topic><topic>Phosphorylation</topic><topic>Signaling</topic><topic>Thymidine</topic><topic>Tumor necrosis factor-TNF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>He, Jie-Wei</creatorcontrib><creatorcontrib>Guo, Ping</creatorcontrib><creatorcontrib>Yang, Li</creatorcontrib><creatorcontrib>He, Jun-Wei</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>RSC advances</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>He, Jie-Wei</au><au>Guo, Ping</au><au>Yang, Li</au><au>He, Jun-Wei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-inflammatory constituents isolated from the flowers of Hosta plantaginea via suppression of the NF-κB signaling pathway in LPS-stimulated RAW 264.7 macrophages</atitle><jtitle>RSC advances</jtitle><addtitle>RSC Adv</addtitle><date>2023-03-01</date><risdate>2023</risdate><volume>13</volume><issue>11</issue><spage>7179</spage><epage>7184</epage><pages>7179-7184</pages><issn>2046-2069</issn><eissn>2046-2069</eissn><abstract>(Lam.) Aschers flower is traditionally used in China as an important herbal medicine for the treatment of inflammatory disease. The present study isolated one new compound, namely (3
)-dihydrobonducellin (1), and five known ones,
-hydroxycinnamic acid (2), paprazine (3), thymidine (4), bis(2-ethylhexyl) phthalate (5), and dibutyl phthalate (6) from
flowers. These structures were elucidated from spectroscopic data. Among them, compounds 1-4 remarkably suppressed nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264.7 cells with half maximal inhibitory concentration (IC
) values of 19.88 ± 1.81, 39.80 ± 0.85, 19.03 ± 2.35, and 34.63 ± 2.38 μM, respectively. Furthermore, compounds 1 and 3 (20 μM) significantly decreased levels of tumor necrosis factor α (TNF-α), prostaglandin E2 (PGE2), interleukin 1β (IL-1β), and IL-6. Additionally, compounds 1 and 3 (20 μM) prominently reduced the phosphorylation protein level of nuclear factor kappa-B (NF-κB) p65. The present findings indicated that compounds 1 and 3 may be new candidates against inflammation
blocking the NF-κB signaling pathway.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>36875879</pmid><doi>10.1039/d2ra07623c</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-6376-3505</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Chemistry Dibutyl phthalate Dioctyl phthalate Flowers Herbal medicine Hydroxycinnamic acid Interleukins Macrophages Nitric oxide Phosphorylation Signaling Thymidine Tumor necrosis factor-TNF |
| title | Anti-inflammatory constituents isolated from the flowers of Hosta plantaginea via suppression of the NF-κB signaling pathway in LPS-stimulated RAW 264.7 macrophages |
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