Super resolution microscopy analysis reveals increased Orai1 activity in asthma and cystic fibrosis lungs

•In the lung, Orai1 expression is highest in immune cells.•Orai1/STIM1 colocalization is increased in asthma and CF lung epithelial, interstitial, and luminal immune cells.•Orai1 aggregation and activation is increased in asthmatic and CF lung immune cells.•Orai1 activation is elevated in CF patient...

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Veröffentlicht in:	Journal of cystic fibrosis 2023-01, Vol.22 (1), p.161-171
Hauptverfasser:	Goriounova, Alexandra S., Gilmore, Rodney C., Wrennall, Joe A., Tarran, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Asthma Calcium - metabolism Calcium Channels - genetics Calcium Channels - metabolism Cystic Fibrosis Humans Inflammation Lung - metabolism Microscopy ORAI1 Protein Orai1/STIM1 RNAscope Super resolution microscopy
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