Collateralizing ventral subiculum melanocortin 4 receptor circuits regulate energy balance and food motivation

•NAc-projecting vSUBMC4R+ neurons send collateral projections to hypothalamic nuclei.•Activation of NAc-projecting vSUBMC4R+neurons affect appetitive behavior.•Re-expression of vSUBMC4Rs partially ameliorate obesity in MC4R-null mice. Hippocampal dysfunction is associated with major depressive disor...

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Veröffentlicht in:	Physiology & behavior 2023-04, Vol.262, p.114105-114105, Article 114105
Hauptverfasser:	Singh, Uday, Saito, Kenji, Khan, Michael Z., Jiang, Jingwei, Toth, Brandon A., Rodeghiero, Samuel R., Dickey, Jacob E., Deng, Yue, Deng, Guorui, Kim, Young-Cho, Cui, Huxing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Depressive Disorder, Major - metabolism Energy homeostasis Food motivation Hippocampus - metabolism Major depressive disorder Melanocortin 4 receptor Mice Mice, Knockout Motivation Nucleus accumbens Nucleus Accumbens - metabolism Receptor, Melanocortin, Type 4 - metabolism Ventral subiculum
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