Identification of astrocyte regulators by nucleic acid cytometry

Multiple sclerosis is a chronic inflammatory disease of the central nervous system 1 . Astrocytes are heterogeneous glial cells that are resident in the central nervous system and participate in the pathogenesis of multiple sclerosis and its model experimental autoimmune encephalomyelitis 2 , 3 . Ho...

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Veröffentlicht in:	Nature (London) 2023-02, Vol.614 (7947), p.326-333
Hauptverfasser:	Clark, Iain C., Wheeler, Michael A., Lee, Hong-Gyun, Li, Zhaorong, Sanmarco, Liliana M., Thaploo, Shravan, Polonio, Carolina M., Shin, Seung Won, Scalisi, Giulia, Henry, Amy R., Rone, Joseph M., Giovannoni, Federico, Charabati, Marc, Akl, Camilo Faust, Aleman, Dulce M., Zandee, Stephanie E. J., Prat, Alexandre, Douek, Daniel C., Boritz, Eli A., Quintana, Francisco J., Abate, Adam R.
Format:	Artikel
Sprache:	eng
Schlagworte:	38/22 38/62 38/90 38/91 631/1647/514 631/250/371 Acids Animals Astrocytes Astrocytes - metabolism Astrocytes - pathology Autoimmune diseases Biomarkers Cells Central nervous system Cytometry Droplets Encephalomyelitis, Autoimmune, Experimental Experimental allergic encephalomyelitis Gene Editing Gene expression Gene Expression Regulation Gene sequencing Genomes Glial cells Humanities and Social Sciences Humans Hydrogels In vivo methods and tests Inflammatory diseases Interrogation Mice Mice, Knockout Microfluidics Microfluidics - methods multidisciplinary Multiple sclerosis Multiple Sclerosis - pathology Nervous system Nucleic acids Nucleic Acids - analysis Pathogenesis Pathology Perturbation Science Science (multidisciplinary) Single-Cell Gene Expression Analysis - methods Splicing Surface markers Target detection Therapeutic targets Thermal cycling Transcription activation Transcription factors Transcriptomics
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