High levels of fecal calprotectin and C-reactive protein in patients with colitis
Inflammatory bowel disease (IBD) with a poor prognosis may be due to persistent colitis. According to the latest guidelines, monitoring has become a part of the treatment process for colitis. Adequate monitoring of the patient's condition is necessary to determine the course of the disease to p...
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| Veröffentlicht in: | Journal of medicine and life 2023-01, Vol.16 (1), p.48-51 |
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| creator | Anindita, Brinna Sugihartono, Titong Miftahussurur, Muhammad Maimunah, Ummi Nusi, Iswan Abbas Setiawan, Poernomo Boedi Purbayu, Herry Kholili, Ulfa Widodo, Budi Thamrin, Husin Vidyani, Amie Rezkitha, Yudith Annisa Ayu Yamaoka, Yoshio |
| description | Inflammatory bowel disease (IBD) with a poor prognosis may be due to persistent colitis. According to the latest guidelines, monitoring has become a part of the treatment process for colitis. Adequate monitoring of the patient's condition is necessary to determine the course of the disease to prevent the worsening of the condition and suppress the subclinical inflammatory process. This analytical study with a cross-sectional design was conducted to evaluate the activity of colitis using the results of C-reactive protein (CRP) and fecal calprotectin (FC) assays. FC levels were analyzed by ELISA, while CRP levels were analyzed using Siemens Flex particle-enhanced turbidimetric immunoassay. In 30 subjects with endoscopy and biopsy of colitis, 16 men and 14 women had a median age of 52.5 (18-70) years. The median FC value increased by 67 (7.3-722 g/g) and was positive (≥50 g/g) in 20 subjects (66.7%), and the mean CRP value was 13.64 mg/L, positive (10-15 mg/L) in 13 subjects (43.33%), and negative ( |
| doi_str_mv | 10.25122/jml-2021-0311 |
| format | Article |
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E-mail: muhammad-m@fk.unair.ac.id ; Helicobacter pylori and Microbiota Study Group, Institute Tropical Disease, Universitas Airlangga, Surabaya, Indonesia ; Corresponding Author: Titong Sugihartono, Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia. E-mail: titongsppd@gmail.com ; Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia ; Department of Internal Medicine, Dr. Soetomo Teaching Hospital, Faculty of Medicine Universitas Airlangga, Surabaya, Indonesia ; Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu, Japan ; Department of Internal Medicine, Faculty of Medicine, University of Muhammadiyah Surabaya, Surabaya, Indonesia</creatorcontrib><description>Inflammatory bowel disease (IBD) with a poor prognosis may be due to persistent colitis. According to the latest guidelines, monitoring has become a part of the treatment process for colitis. Adequate monitoring of the patient's condition is necessary to determine the course of the disease to prevent the worsening of the condition and suppress the subclinical inflammatory process. This analytical study with a cross-sectional design was conducted to evaluate the activity of colitis using the results of C-reactive protein (CRP) and fecal calprotectin (FC) assays. FC levels were analyzed by ELISA, while CRP levels were analyzed using Siemens Flex particle-enhanced turbidimetric immunoassay. In 30 subjects with endoscopy and biopsy of colitis, 16 men and 14 women had a median age of 52.5 (18-70) years. The median FC value increased by 67 (7.3-722 g/g) and was positive (≥50 g/g) in 20 subjects (66.7%), and the mean CRP value was 13.64 mg/L, positive (10-15 mg/L) in 13 subjects (43.33%), and negative (<10 mg/L) in 17 subjects (56.67%). This study demonstrated that FC had a significant relationship with CRP (r=0.57; p<0.001) in patients with colitis. Assessing the levels of FC and CRP among patients with colitis can be useful to assess the worsening of symptoms early and reduce mortality and morbidity.</description><identifier>ISSN: 1844-122X</identifier><identifier>EISSN: 1844-3117</identifier><identifier>DOI: 10.25122/jml-2021-0311</identifier><identifier>PMID: 36873123</identifier><language>eng</language><publisher>Romania: Carol Daila University Foundation</publisher><subject>Abdomen ; Aged ; Biomarkers ; Biopsy ; C-Reactive Protein ; Colitis ; Colonoscopy ; Cross-Sectional Studies ; Cytokines ; Diarrhea ; Endoscopy ; Feces ; Female ; Gastroenterology ; Humans ; Immunoassay ; Inflammation ; Inflammatory bowel disease ; Inflammatory Bowel Diseases ; Large intestine ; Leukocyte L1 Antigen Complex ; Male ; Middle Aged ; Original ; Pathology ; Patients ; Proteins ; Remission (Medicine) ; Serology ; Statistical analysis ; Tumor necrosis factor-TNF</subject><ispartof>Journal of medicine and life, 2023-01, Vol.16 (1), p.48-51</ispartof><rights>2022 JOURNAL of MEDICINE and LIFE.</rights><rights>Copyright Carol Daila University Foundation Jan 2023</rights><rights>2022 JOURNAL of MEDICINE and LIFE 2022</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3331-61130def44ded7ff2ea434d17d45cf68a323ea89d39414b0e38165795fee58723</citedby><cites>FETCH-LOGICAL-c3331-61130def44ded7ff2ea434d17d45cf68a323ea89d39414b0e38165795fee58723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979164/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979164/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36873123$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Anindita, Brinna</creatorcontrib><creatorcontrib>Sugihartono, Titong</creatorcontrib><creatorcontrib>Miftahussurur, Muhammad</creatorcontrib><creatorcontrib>Maimunah, Ummi</creatorcontrib><creatorcontrib>Nusi, Iswan Abbas</creatorcontrib><creatorcontrib>Setiawan, Poernomo Boedi</creatorcontrib><creatorcontrib>Purbayu, Herry</creatorcontrib><creatorcontrib>Kholili, Ulfa</creatorcontrib><creatorcontrib>Widodo, Budi</creatorcontrib><creatorcontrib>Thamrin, Husin</creatorcontrib><creatorcontrib>Vidyani, Amie</creatorcontrib><creatorcontrib>Rezkitha, Yudith Annisa Ayu</creatorcontrib><creatorcontrib>Yamaoka, Yoshio</creatorcontrib><creatorcontrib>Muhammad Miftahussurur, Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia. E-mail: muhammad-m@fk.unair.ac.id</creatorcontrib><creatorcontrib>Helicobacter pylori and Microbiota Study Group, Institute Tropical Disease, Universitas Airlangga, Surabaya, Indonesia</creatorcontrib><creatorcontrib>Corresponding Author: Titong Sugihartono, Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia. E-mail: titongsppd@gmail.com</creatorcontrib><creatorcontrib>Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia</creatorcontrib><creatorcontrib>Department of Internal Medicine, Dr. Soetomo Teaching Hospital, Faculty of Medicine Universitas Airlangga, Surabaya, Indonesia</creatorcontrib><creatorcontrib>Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu, Japan</creatorcontrib><creatorcontrib>Department of Internal Medicine, Faculty of Medicine, University of Muhammadiyah Surabaya, Surabaya, Indonesia</creatorcontrib><title>High levels of fecal calprotectin and C-reactive protein in patients with colitis</title><title>Journal of medicine and life</title><addtitle>J Med Life</addtitle><description>Inflammatory bowel disease (IBD) with a poor prognosis may be due to persistent colitis. According to the latest guidelines, monitoring has become a part of the treatment process for colitis. Adequate monitoring of the patient's condition is necessary to determine the course of the disease to prevent the worsening of the condition and suppress the subclinical inflammatory process. This analytical study with a cross-sectional design was conducted to evaluate the activity of colitis using the results of C-reactive protein (CRP) and fecal calprotectin (FC) assays. FC levels were analyzed by ELISA, while CRP levels were analyzed using Siemens Flex particle-enhanced turbidimetric immunoassay. In 30 subjects with endoscopy and biopsy of colitis, 16 men and 14 women had a median age of 52.5 (18-70) years. The median FC value increased by 67 (7.3-722 g/g) and was positive (≥50 g/g) in 20 subjects (66.7%), and the mean CRP value was 13.64 mg/L, positive (10-15 mg/L) in 13 subjects (43.33%), and negative (<10 mg/L) in 17 subjects (56.67%). This study demonstrated that FC had a significant relationship with CRP (r=0.57; p<0.001) in patients with colitis. Assessing the levels of FC and CRP among patients with colitis can be useful to assess the worsening of symptoms early and reduce mortality and morbidity.</description><subject>Abdomen</subject><subject>Aged</subject><subject>Biomarkers</subject><subject>Biopsy</subject><subject>C-Reactive Protein</subject><subject>Colitis</subject><subject>Colonoscopy</subject><subject>Cross-Sectional Studies</subject><subject>Cytokines</subject><subject>Diarrhea</subject><subject>Endoscopy</subject><subject>Feces</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Humans</subject><subject>Immunoassay</subject><subject>Inflammation</subject><subject>Inflammatory bowel disease</subject><subject>Inflammatory Bowel Diseases</subject><subject>Large intestine</subject><subject>Leukocyte L1 Antigen Complex</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Original</subject><subject>Pathology</subject><subject>Patients</subject><subject>Proteins</subject><subject>Remission (Medicine)</subject><subject>Serology</subject><subject>Statistical analysis</subject><subject>Tumor necrosis factor-TNF</subject><issn>1844-122X</issn><issn>1844-3117</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkdFLHDEQxoNUVNTXPkqgL31Zm2SyyealUA6rgiCCQt9C3J14OXKba7J34n_fnJ7SNiRkkvnyMZMfIZ85OxctF-LbYhkbwQRvGHC-R454J2VTQ_1pF1fRr0NyWsqC1SFbpRQckENQnQYu4IjcXYWnOY24wVho8tRj7yKta5XThP0URurGgc6ajK6eNkhfE_W6zpWbAo5Toc9hmtM-xTCFckL2vYsFT3f7MXn4eXE_u2pubi-vZz9umh4AeKM4Bzagl3LAQXsv0EmQA9eDbHuvOgcC0HVmACO5fGQIHVetNq1HbDst4Jh8f_NdrR-XOPS1kOyiXeWwdPnFJhfsv5kxzO1T2lhjtOFKVoOvO4Ocfq-xTHYZSo8xuhHTulihO9CGGWmq9Mt_0kVa57G2Z0VXv5srJreG52-qPqdSMvqPYjizr8BsBWa3wOwWWH1w9ncLH_J3PPAHHEyRIg</recordid><startdate>202301</startdate><enddate>202301</enddate><creator>Anindita, Brinna</creator><creator>Sugihartono, Titong</creator><creator>Miftahussurur, Muhammad</creator><creator>Maimunah, Ummi</creator><creator>Nusi, Iswan Abbas</creator><creator>Setiawan, Poernomo Boedi</creator><creator>Purbayu, Herry</creator><creator>Kholili, Ulfa</creator><creator>Widodo, Budi</creator><creator>Thamrin, Husin</creator><creator>Vidyani, Amie</creator><creator>Rezkitha, Yudith Annisa Ayu</creator><creator>Yamaoka, Yoshio</creator><general>Carol Daila University Foundation</general><general>Carol Davila University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BYOGL</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>202301</creationdate><title>High levels of fecal calprotectin and C-reactive protein in patients with colitis</title><author>Anindita, Brinna ; Sugihartono, Titong ; Miftahussurur, Muhammad ; Maimunah, Ummi ; Nusi, Iswan Abbas ; Setiawan, Poernomo Boedi ; Purbayu, Herry ; Kholili, Ulfa ; Widodo, Budi ; Thamrin, Husin ; Vidyani, Amie ; Rezkitha, Yudith Annisa Ayu ; Yamaoka, Yoshio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3331-61130def44ded7ff2ea434d17d45cf68a323ea89d39414b0e38165795fee58723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Abdomen</topic><topic>Aged</topic><topic>Biomarkers</topic><topic>Biopsy</topic><topic>C-Reactive Protein</topic><topic>Colitis</topic><topic>Colonoscopy</topic><topic>Cross-Sectional Studies</topic><topic>Cytokines</topic><topic>Diarrhea</topic><topic>Endoscopy</topic><topic>Feces</topic><topic>Female</topic><topic>Gastroenterology</topic><topic>Humans</topic><topic>Immunoassay</topic><topic>Inflammation</topic><topic>Inflammatory bowel disease</topic><topic>Inflammatory Bowel Diseases</topic><topic>Large intestine</topic><topic>Leukocyte L1 Antigen Complex</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Original</topic><topic>Pathology</topic><topic>Patients</topic><topic>Proteins</topic><topic>Remission (Medicine)</topic><topic>Serology</topic><topic>Statistical analysis</topic><topic>Tumor necrosis factor-TNF</topic><toplevel>online_resources</toplevel><creatorcontrib>Anindita, Brinna</creatorcontrib><creatorcontrib>Sugihartono, Titong</creatorcontrib><creatorcontrib>Miftahussurur, Muhammad</creatorcontrib><creatorcontrib>Maimunah, Ummi</creatorcontrib><creatorcontrib>Nusi, Iswan Abbas</creatorcontrib><creatorcontrib>Setiawan, Poernomo Boedi</creatorcontrib><creatorcontrib>Purbayu, Herry</creatorcontrib><creatorcontrib>Kholili, Ulfa</creatorcontrib><creatorcontrib>Widodo, Budi</creatorcontrib><creatorcontrib>Thamrin, Husin</creatorcontrib><creatorcontrib>Vidyani, Amie</creatorcontrib><creatorcontrib>Rezkitha, Yudith Annisa Ayu</creatorcontrib><creatorcontrib>Yamaoka, Yoshio</creatorcontrib><creatorcontrib>Muhammad Miftahussurur, Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia. 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E-mail: muhammad-m@fk.unair.ac.id</aucorp><aucorp>Helicobacter pylori and Microbiota Study Group, Institute Tropical Disease, Universitas Airlangga, Surabaya, Indonesia</aucorp><aucorp>Corresponding Author: Titong Sugihartono, Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia. E-mail: titongsppd@gmail.com</aucorp><aucorp>Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia</aucorp><aucorp>Department of Internal Medicine, Dr. Soetomo Teaching Hospital, Faculty of Medicine Universitas Airlangga, Surabaya, Indonesia</aucorp><aucorp>Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu, Japan</aucorp><aucorp>Department of Internal Medicine, Faculty of Medicine, University of Muhammadiyah Surabaya, Surabaya, Indonesia</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High levels of fecal calprotectin and C-reactive protein in patients with colitis</atitle><jtitle>Journal of medicine and life</jtitle><addtitle>J Med Life</addtitle><date>2023-01</date><risdate>2023</risdate><volume>16</volume><issue>1</issue><spage>48</spage><epage>51</epage><pages>48-51</pages><issn>1844-122X</issn><eissn>1844-3117</eissn><abstract>Inflammatory bowel disease (IBD) with a poor prognosis may be due to persistent colitis. According to the latest guidelines, monitoring has become a part of the treatment process for colitis. Adequate monitoring of the patient's condition is necessary to determine the course of the disease to prevent the worsening of the condition and suppress the subclinical inflammatory process. This analytical study with a cross-sectional design was conducted to evaluate the activity of colitis using the results of C-reactive protein (CRP) and fecal calprotectin (FC) assays. FC levels were analyzed by ELISA, while CRP levels were analyzed using Siemens Flex particle-enhanced turbidimetric immunoassay. In 30 subjects with endoscopy and biopsy of colitis, 16 men and 14 women had a median age of 52.5 (18-70) years. The median FC value increased by 67 (7.3-722 g/g) and was positive (≥50 g/g) in 20 subjects (66.7%), and the mean CRP value was 13.64 mg/L, positive (10-15 mg/L) in 13 subjects (43.33%), and negative (<10 mg/L) in 17 subjects (56.67%). 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| fulltext | fulltext |
| identifier | ISSN: 1844-122X |
| ispartof | Journal of medicine and life, 2023-01, Vol.16 (1), p.48-51 |
| issn | 1844-122X 1844-3117 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9979164 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Abdomen Aged Biomarkers Biopsy C-Reactive Protein Colitis Colonoscopy Cross-Sectional Studies Cytokines Diarrhea Endoscopy Feces Female Gastroenterology Humans Immunoassay Inflammation Inflammatory bowel disease Inflammatory Bowel Diseases Large intestine Leukocyte L1 Antigen Complex Male Middle Aged Original Pathology Patients Proteins Remission (Medicine) Serology Statistical analysis Tumor necrosis factor-TNF |
| title | High levels of fecal calprotectin and C-reactive protein in patients with colitis |
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