Lactate dehydrogenase: relationship with the diagnostic GLIM criterion for cachexia in patients with advanced cancer
Background Although suggestive of dysregulated metabolism, the relationship between serum LDH level, phenotypic/aetiologic diagnostic Global Leadership Initiative on Malnutrition (GLIM) criteria and survival in patients with advanced cancer has yet to examined. Methods Prospectively collected data f...
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| Veröffentlicht in: | British journal of cancer 2023-03, Vol.128 (5), p.760-765 |
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| creator | McGovern, Josh Dolan, Ross D. Simmons, Claribel P. L. Daly, Louise E. Ryan, Aoife M. Power, Derek G. Maguire, Donogh Fallon, Marie T. Laird, Barry J. McMillan, Donald C. |
| description | Background
Although suggestive of dysregulated metabolism, the relationship between serum LDH level, phenotypic/aetiologic diagnostic Global Leadership Initiative on Malnutrition (GLIM) criteria and survival in patients with advanced cancer has yet to examined.
Methods
Prospectively collected data from patients with advanced cancer, undergoing anti-cancer therapy with palliative intent, across nine sites in the UK and Ireland between 2011–2016, was retrospectively analysed. LDH values were grouped as 500 Units/L. Relationships were examined using χ
2
test for linear-by-linear association and binary logistics regression analysis.
Results
A total of 436 patients met the inclusion criteria. 46% (
n
= 200) were male and 59% (
n
= 259) were ≥65 years of age. The median serum LDH was 394 Units/L and 33.5% (
n
= 146) had an LDH > 500 Units/L. LDH was significantly associated with ECOG-PS (
p
|
| doi_str_mv | 10.1038/s41416-022-02099-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9977728</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2754858913</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-ee499e1e93ea60516f86fd2abe4daef3be7454c1e65ed4547df9cdf4ed43bf593</originalsourceid><addsrcrecordid>eNp9kcFvFCEUxomxsWv1H_BgSLx4GQszMAweTJpGa5M1XvRMWHizQzMLK7DV_vc-nVpbDx7I44Xf9_FePkJecPaGs244LYIL3jesbfEwrRv5iKy47NqGD616TFaMMdUw3bJj8rSUK2w1G9QTctz1kisp2YrUtXXVVqAephuf0xaiLfCWZphtDSmWKezp91AnWieEgt3GVGpw9GJ9-Ym6HCpkxOiYMnXWTfAjWBoi3aMaYi2L1vprGx14RLDkZ-RotHOB57f1hHz98P7L-cdm_fni8vxs3TihRG0AhNbAQXdgeyZ5Pw796Fu7AeEtjN0GlJDCcegleLwpP2rnR4FNtxml7k7Iu8V3f9jswDscKNvZ7HPY2Xxjkg3m4UsMk9mma6O1Uqod0OD1rUFO3w5QqtmF4mCebYR0KKZVUgxy0LxD9NU_6FU65IjrITVgXr1SPVLtQrmcSskw3g3DmfkVqllCNRiq-R2qkSh6eX-NO8mfFBHoFqDgU9xC_vv3f2x_Av54sJM</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2781036776</pqid></control><display><type>article</type><title>Lactate dehydrogenase: relationship with the diagnostic GLIM criterion for cachexia in patients with advanced cancer</title><source>MEDLINE</source><source>SpringerLink Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>McGovern, Josh ; Dolan, Ross D. ; Simmons, Claribel P. L. ; Daly, Louise E. ; Ryan, Aoife M. ; Power, Derek G. ; Maguire, Donogh ; Fallon, Marie T. ; Laird, Barry J. ; McMillan, Donald C.</creator><creatorcontrib>McGovern, Josh ; Dolan, Ross D. ; Simmons, Claribel P. L. ; Daly, Louise E. ; Ryan, Aoife M. ; Power, Derek G. ; Maguire, Donogh ; Fallon, Marie T. ; Laird, Barry J. ; McMillan, Donald C.</creatorcontrib><description><![CDATA[Background
Although suggestive of dysregulated metabolism, the relationship between serum LDH level, phenotypic/aetiologic diagnostic Global Leadership Initiative on Malnutrition (GLIM) criteria and survival in patients with advanced cancer has yet to examined.
Methods
Prospectively collected data from patients with advanced cancer, undergoing anti-cancer therapy with palliative intent, across nine sites in the UK and Ireland between 2011–2016, was retrospectively analysed. LDH values were grouped as <250/250–500/>500 Units/L. Relationships were examined using χ
2
test for linear-by-linear association and binary logistics regression analysis.
Results
A total of 436 patients met the inclusion criteria. 46% (
n
= 200) were male and 59% (
n
= 259) were ≥65 years of age. The median serum LDH was 394 Units/L and 33.5% (
n
= 146) had an LDH > 500 Units/L. LDH was significantly associated with ECOG-PS (
p
< 0.001), NLR (
p
< 0.05), mGPS (
p
< 0.05) and 3-month survival (
p
< 0.001). LDH was significantly associated with 3-month survival independent of weight loss (
p
< 0.01), BMI (
p
< 0.05), skeletal muscle mass (
p
< 0.01), metastatic disease (
p
< 0.05), NLR (
p
< 0.05) and mGPS (
p
< 0.01).
Discussion
LDH was associated with performance status, systemic inflammation and survival in patients with advanced cancer. LDH measurement may be considered as an aetiologic criteria and become a potential therapeutic target in the treatment of cancer cachexia.]]></description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/s41416-022-02099-5</identifier><identifier>PMID: 36517550</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/67/2327 ; 631/80/221 ; Biomedical and Life Sciences ; Biomedicine ; Cachexia ; Cancer ; Cancer Research ; Drug Resistance ; Epidemiology ; Female ; Humans ; L-Lactate Dehydrogenase ; Lactic acid ; Leadership ; Male ; Malnutrition ; Malnutrition - diagnosis ; Medical diagnosis ; Metastases ; Molecular Medicine ; Neoplasms - pathology ; Nutrition Assessment ; Nutritional Status ; Oncology ; Retrospective Studies ; Skeletal muscle ; Survival ; Therapeutic targets</subject><ispartof>British journal of cancer, 2023-03, Vol.128 (5), p.760-765</ispartof><rights>The Author(s) 2022</rights><rights>2022. The Author(s).</rights><rights>The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-ee499e1e93ea60516f86fd2abe4daef3be7454c1e65ed4547df9cdf4ed43bf593</citedby><cites>FETCH-LOGICAL-c474t-ee499e1e93ea60516f86fd2abe4daef3be7454c1e65ed4547df9cdf4ed43bf593</cites><orcidid>0000-0003-4260-5334 ; 0000-0002-5272-5906 ; 0000-0002-6889-6240</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977728/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977728/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36517550$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McGovern, Josh</creatorcontrib><creatorcontrib>Dolan, Ross D.</creatorcontrib><creatorcontrib>Simmons, Claribel P. L.</creatorcontrib><creatorcontrib>Daly, Louise E.</creatorcontrib><creatorcontrib>Ryan, Aoife M.</creatorcontrib><creatorcontrib>Power, Derek G.</creatorcontrib><creatorcontrib>Maguire, Donogh</creatorcontrib><creatorcontrib>Fallon, Marie T.</creatorcontrib><creatorcontrib>Laird, Barry J.</creatorcontrib><creatorcontrib>McMillan, Donald C.</creatorcontrib><title>Lactate dehydrogenase: relationship with the diagnostic GLIM criterion for cachexia in patients with advanced cancer</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description><![CDATA[Background
Although suggestive of dysregulated metabolism, the relationship between serum LDH level, phenotypic/aetiologic diagnostic Global Leadership Initiative on Malnutrition (GLIM) criteria and survival in patients with advanced cancer has yet to examined.
Methods
Prospectively collected data from patients with advanced cancer, undergoing anti-cancer therapy with palliative intent, across nine sites in the UK and Ireland between 2011–2016, was retrospectively analysed. LDH values were grouped as <250/250–500/>500 Units/L. Relationships were examined using χ
2
test for linear-by-linear association and binary logistics regression analysis.
Results
A total of 436 patients met the inclusion criteria. 46% (
n
= 200) were male and 59% (
n
= 259) were ≥65 years of age. The median serum LDH was 394 Units/L and 33.5% (
n
= 146) had an LDH > 500 Units/L. LDH was significantly associated with ECOG-PS (
p
< 0.001), NLR (
p
< 0.05), mGPS (
p
< 0.05) and 3-month survival (
p
< 0.001). LDH was significantly associated with 3-month survival independent of weight loss (
p
< 0.01), BMI (
p
< 0.05), skeletal muscle mass (
p
< 0.01), metastatic disease (
p
< 0.05), NLR (
p
< 0.05) and mGPS (
p
< 0.01).
Discussion
LDH was associated with performance status, systemic inflammation and survival in patients with advanced cancer. LDH measurement may be considered as an aetiologic criteria and become a potential therapeutic target in the treatment of cancer cachexia.]]></description><subject>631/67/2327</subject><subject>631/80/221</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cachexia</subject><subject>Cancer</subject><subject>Cancer Research</subject><subject>Drug Resistance</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>L-Lactate Dehydrogenase</subject><subject>Lactic acid</subject><subject>Leadership</subject><subject>Male</subject><subject>Malnutrition</subject><subject>Malnutrition - diagnosis</subject><subject>Medical diagnosis</subject><subject>Metastases</subject><subject>Molecular Medicine</subject><subject>Neoplasms - pathology</subject><subject>Nutrition Assessment</subject><subject>Nutritional Status</subject><subject>Oncology</subject><subject>Retrospective Studies</subject><subject>Skeletal muscle</subject><subject>Survival</subject><subject>Therapeutic targets</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kcFvFCEUxomxsWv1H_BgSLx4GQszMAweTJpGa5M1XvRMWHizQzMLK7DV_vc-nVpbDx7I44Xf9_FePkJecPaGs244LYIL3jesbfEwrRv5iKy47NqGD616TFaMMdUw3bJj8rSUK2w1G9QTctz1kisp2YrUtXXVVqAephuf0xaiLfCWZphtDSmWKezp91AnWieEgt3GVGpw9GJ9-Ym6HCpkxOiYMnXWTfAjWBoi3aMaYi2L1vprGx14RLDkZ-RotHOB57f1hHz98P7L-cdm_fni8vxs3TihRG0AhNbAQXdgeyZ5Pw796Fu7AeEtjN0GlJDCcegleLwpP2rnR4FNtxml7k7Iu8V3f9jswDscKNvZ7HPY2Xxjkg3m4UsMk9mma6O1Uqod0OD1rUFO3w5QqtmF4mCebYR0KKZVUgxy0LxD9NU_6FU65IjrITVgXr1SPVLtQrmcSskw3g3DmfkVqllCNRiq-R2qkSh6eX-NO8mfFBHoFqDgU9xC_vv3f2x_Av54sJM</recordid><startdate>20230323</startdate><enddate>20230323</enddate><creator>McGovern, Josh</creator><creator>Dolan, Ross D.</creator><creator>Simmons, Claribel P. L.</creator><creator>Daly, Louise E.</creator><creator>Ryan, Aoife M.</creator><creator>Power, Derek G.</creator><creator>Maguire, Donogh</creator><creator>Fallon, Marie T.</creator><creator>Laird, Barry J.</creator><creator>McMillan, Donald C.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4260-5334</orcidid><orcidid>https://orcid.org/0000-0002-5272-5906</orcidid><orcidid>https://orcid.org/0000-0002-6889-6240</orcidid></search><sort><creationdate>20230323</creationdate><title>Lactate dehydrogenase: relationship with the diagnostic GLIM criterion for cachexia in patients with advanced cancer</title><author>McGovern, Josh ; Dolan, Ross D. ; Simmons, Claribel P. L. ; Daly, Louise E. ; Ryan, Aoife M. ; Power, Derek G. ; Maguire, Donogh ; Fallon, Marie T. ; Laird, Barry J. ; McMillan, Donald C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-ee499e1e93ea60516f86fd2abe4daef3be7454c1e65ed4547df9cdf4ed43bf593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>631/67/2327</topic><topic>631/80/221</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cachexia</topic><topic>Cancer</topic><topic>Cancer Research</topic><topic>Drug Resistance</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>L-Lactate Dehydrogenase</topic><topic>Lactic acid</topic><topic>Leadership</topic><topic>Male</topic><topic>Malnutrition</topic><topic>Malnutrition - diagnosis</topic><topic>Medical diagnosis</topic><topic>Metastases</topic><topic>Molecular Medicine</topic><topic>Neoplasms - pathology</topic><topic>Nutrition Assessment</topic><topic>Nutritional Status</topic><topic>Oncology</topic><topic>Retrospective Studies</topic><topic>Skeletal muscle</topic><topic>Survival</topic><topic>Therapeutic targets</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McGovern, Josh</creatorcontrib><creatorcontrib>Dolan, Ross D.</creatorcontrib><creatorcontrib>Simmons, Claribel P. L.</creatorcontrib><creatorcontrib>Daly, Louise E.</creatorcontrib><creatorcontrib>Ryan, Aoife M.</creatorcontrib><creatorcontrib>Power, Derek G.</creatorcontrib><creatorcontrib>Maguire, Donogh</creatorcontrib><creatorcontrib>Fallon, Marie T.</creatorcontrib><creatorcontrib>Laird, Barry J.</creatorcontrib><creatorcontrib>McMillan, Donald C.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McGovern, Josh</au><au>Dolan, Ross D.</au><au>Simmons, Claribel P. L.</au><au>Daly, Louise E.</au><au>Ryan, Aoife M.</au><au>Power, Derek G.</au><au>Maguire, Donogh</au><au>Fallon, Marie T.</au><au>Laird, Barry J.</au><au>McMillan, Donald C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lactate dehydrogenase: relationship with the diagnostic GLIM criterion for cachexia in patients with advanced cancer</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>2023-03-23</date><risdate>2023</risdate><volume>128</volume><issue>5</issue><spage>760</spage><epage>765</epage><pages>760-765</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><abstract><![CDATA[Background
Although suggestive of dysregulated metabolism, the relationship between serum LDH level, phenotypic/aetiologic diagnostic Global Leadership Initiative on Malnutrition (GLIM) criteria and survival in patients with advanced cancer has yet to examined.
Methods
Prospectively collected data from patients with advanced cancer, undergoing anti-cancer therapy with palliative intent, across nine sites in the UK and Ireland between 2011–2016, was retrospectively analysed. LDH values were grouped as <250/250–500/>500 Units/L. Relationships were examined using χ
2
test for linear-by-linear association and binary logistics regression analysis.
Results
A total of 436 patients met the inclusion criteria. 46% (
n
= 200) were male and 59% (
n
= 259) were ≥65 years of age. The median serum LDH was 394 Units/L and 33.5% (
n
= 146) had an LDH > 500 Units/L. LDH was significantly associated with ECOG-PS (
p
< 0.001), NLR (
p
< 0.05), mGPS (
p
< 0.05) and 3-month survival (
p
< 0.001). LDH was significantly associated with 3-month survival independent of weight loss (
p
< 0.01), BMI (
p
< 0.05), skeletal muscle mass (
p
< 0.01), metastatic disease (
p
< 0.05), NLR (
p
< 0.05) and mGPS (
p
< 0.01).
Discussion
LDH was associated with performance status, systemic inflammation and survival in patients with advanced cancer. LDH measurement may be considered as an aetiologic criteria and become a potential therapeutic target in the treatment of cancer cachexia.]]></abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>36517550</pmid><doi>10.1038/s41416-022-02099-5</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-4260-5334</orcidid><orcidid>https://orcid.org/0000-0002-5272-5906</orcidid><orcidid>https://orcid.org/0000-0002-6889-6240</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0007-0920 |
| ispartof | British journal of cancer, 2023-03, Vol.128 (5), p.760-765 |
| issn | 0007-0920 1532-1827 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9977728 |
| source | MEDLINE; SpringerLink Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | 631/67/2327 631/80/221 Biomedical and Life Sciences Biomedicine Cachexia Cancer Cancer Research Drug Resistance Epidemiology Female Humans L-Lactate Dehydrogenase Lactic acid Leadership Male Malnutrition Malnutrition - diagnosis Medical diagnosis Metastases Molecular Medicine Neoplasms - pathology Nutrition Assessment Nutritional Status Oncology Retrospective Studies Skeletal muscle Survival Therapeutic targets |
| title | Lactate dehydrogenase: relationship with the diagnostic GLIM criterion for cachexia in patients with advanced cancer |
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