A hepatitis B virus core antigen‐based virus‐like particle vaccine expressing SARS‐CoV‐2 B and T cell epitopes induces epitope‐specific humoral and cell‐mediated immune responses but confers limited protection against SARS‐CoV‐2 infection

The hepatitis B virus core antigen (HBcAg) tolerates insertion of foreign epitopes and maintains its ability to self‐assemble into virus‐like particles (VLPs). We constructed a ∆HBcAg‐based VLP vaccine expressing three predicted severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) B and T ce...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of medical virology 2023-02, Vol.95 (2), p.e28503-n/a
Hauptverfasser:	Hassebroek, Anna M., Sooryanarain, Harini, Heffron, Connie L., Hawks, Seth A., LeRoith, Tanya, Cecere, Thomas E., Stone, William B., Walter, Debra, Mahsoub, Hassan M., Wang, Bo, Tian, Debin, Ivester, Hannah M., Allen, Irving C., Auguste, Albert J., Duggal, Nisha K., Zhang, Chenming, Meng, Xiang‐Jin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens B cell epitope CD8 antigen cell‐mediated immune response Core protein Coronaviruses COVID-19 E coli Epitopes Epitopes, T-Lymphocyte Hepatitis Hepatitis B hepatitis B core antigen (HBcAg) Hepatitis B Core Antigens - genetics Hepatitis B virus - genetics humoral immune response IgG antibody Immune response (humoral) Immunity, Cellular Immunization Immunogenicity Immunoglobulin G Infections Interferon Interleukin 6 Lymphocytes Lymphocytes T Mice Mice, Inbred C57BL Monocyte chemoattractant protein Monocytes Proteins Recombinant Proteins Respiratory diseases SARS-CoV-2 Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Statistical analysis T cell epitope Transgenic mice Tumor necrosis factor-TNF vaccine Vaccines Vaccines, Virus-Like Particle Viral diseases Virology Viruses virus‐like particle (VLP)
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!