Helminth egg derivatives as proregenerative immunotherapies

The immune system is increasingly recognized as an important regulator of tissue repair. We developed a regenerative immunotherapy from the helminth soluble egg antigen (SEA) to stimulate production of interleukin (IL)-4 and other type 2-associated cytokines without negative infection-related sequel...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2023-02, Vol.120 (8), p.e2211703120-e2211703120
Hauptverfasser:	Maestas, Jr, David R, Chung, Liam, Han, Jin, Wang, Xiaokun, Sommerfeld, Sven D, Kelly, Sean H, Moore, Erika, Nguyen, Helen Hieu, Mejías, Joscelyn C, Peña, Alexis N, Zhang, Hong, Hooks, Joshua S T, Chin, Alexander F, Andorko, James I, Berlinicke, Cynthia A, Krishnan, Kavita, Choi, Younghwan, Anderson, Amy E, Mahatme, Ronak, Mejia, Christopher, Eric, Marie, Woo, JiWon, Ganguly, Sudipto, Zack, Donald J, Zhao, Liang, Pearce, Edward J, Housseau, Franck, Pardoll, Drew M, Elisseeff, Jennifer H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Antigens, Helminth Biological Sciences Complications Controlled release Cornea Cytokines - metabolism Eggs Eosinophils Fibrosis Helper cells Hydrogels Immune system Immunoregulation Immunotherapy Interleukin 4 Leukocytes (eosinophilic) Lymphocytes Lymphocytes T Mice Muscles Schistosoma mansoni Schistosomiasis mansoni - therapy Soluble egg antigen T-Lymphocytes, Helper-Inducer
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