Aging and CNS Myeloid Cell Depletion Attenuate Breast Cancer Brain Metastasis

Breast cancer diagnosed in young patients is often aggressive. Because primary breast tumors from young and older patients have similar mutational patterns, we hypothesized that the young host microenvironment promotes more aggressive metastatic disease. Triple-negative or luminal B breast cancer ce...

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Veröffentlicht in:	Clinical cancer research 2021-08, Vol.27 (15), p.4422-4434
Hauptverfasser:	Wu, Alex Man Lai, Gossa, Selamawit, Samala, Ramakrishna, Chung, Monika A, Gril, Brunilde, Yang, Howard H, Thorsheim, Helen R, Tran, Andy D, Wei, Debbie, Taner, Esra, Isanogle, Kristine, Yang, Yuan, Dolan, Emma L, Robinson, Christina, Difilippantonio, Simone, Lee, Maxwell P, Khan, Imran, Smith, Quentin R, McGavern, Dorian B, Wakefield, Lalage M, Steeg, Patricia S
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Animals Brain Neoplasms - secondary Cell Line, Tumor Central Nervous System - cytology Humans Mice Myeloid Cells Receptor, Macrophage Colony-Stimulating Factor - physiology Triple Negative Breast Neoplasms - pathology
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