Resistance To Poxvirus Lethality Does Not Require the Necroptosis Proteins RIPK3 or MLKL

Receptor-interacting protein kinase 3 (RIPK3) and mixed lineage kinase domain-like pseudokinase (MLKL) are proteins that are critical for necroptosis, a mechanism of programmed cell death that is both activated when apoptosis is inhibited and thought to be antiviral. Here, we investigated the role o...

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Veröffentlicht in:	Journal of virology 2023-02, Vol.97 (2), p.e0194522-e0194522
Hauptverfasser:	Montoya, Brian, Knudson, Cory J, Melo-Silva, Carolina R, Tang, Lingjuan, Kafle, Samita, Sigal, Luis J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ectromelia virus Ectromelia, Infectious - immunology Interferons - metabolism Mice Mice, Inbred C57BL Necroptosis - immunology Pathogenesis and Immunity Protein Kinases - genetics Protein Kinases - immunology Receptor-Interacting Protein Serine-Threonine Kinases - genetics Receptor-Interacting Protein Serine-Threonine Kinases - immunology Virology
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