Immunoexpression of Tumor Infiltrating Lymphocytes(TILS) CD4 + and CD8 + in Oral Squamous Cell Carcinoma (OSCC) in Correlations with Clinicopathological Characteristics and Prognosis
This study aimed to analyze CD4 +and CD8 + TILs in oral squamous cell carcinoma (OSCC) and to correlate it with histologic grade of malignancy and clinicopathologic data. The sample was composed of 43 archived specimens. Clinical features and histological grade of malignancy were obtained. The infil...
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| Veröffentlicht in: | Asian Pacific Journal of Cancer Prevention 2022-12, Vol.23 (12), p.4177-4183 |
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| creator | Wahbi, Hanan Salman Manadili, Ahmad |
| description | This study aimed to analyze CD4 +and CD8 + TILs in oral squamous cell carcinoma (OSCC) and to correlate it with histologic grade of malignancy and clinicopathologic data.
The sample was composed of 43 archived specimens. Clinical features and histological grade of malignancy were obtained. The infiltrating intensity of CD4 +, CD8 positive cells were assessed by immunohistochemistry. One-way ANOVA was used to study the association between CD4 +, CD8 + and the grade of OSCC. The cut-off values of the proposed diagnostic indices were received from calculating the coordinates of the receiver operating characteristic (ROC) curve. For clinicopathologic data Independent-Samples T test, Pearson Correlation Coefficient, Correlation Coefficient were used clinicopathologic characteristics.
CD4 +and CD8 + were observed in all specimens. CD4 + were more frequent in poorly differentiated specimens (74.14) (P= 0.0210.05). CD4 +/ CD8 ratio was higher in low-grade specimens (180.28) (P=0.017 |
| doi_str_mv | 10.31557/APJCP.2022.23.12.4177 |
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The sample was composed of 43 archived specimens. Clinical features and histological grade of malignancy were obtained. The infiltrating intensity of CD4 +, CD8 positive cells were assessed by immunohistochemistry. One-way ANOVA was used to study the association between CD4 +, CD8 + and the grade of OSCC. The cut-off values of the proposed diagnostic indices were received from calculating the coordinates of the receiver operating characteristic (ROC) curve. For clinicopathologic data Independent-Samples T test, Pearson Correlation Coefficient, Correlation Coefficient were used clinicopathologic characteristics.
CD4 +and CD8 + were observed in all specimens. CD4 + were more frequent in poorly differentiated specimens (74.14) (P= 0.021<0.05). CD8 + were more frequent in well- differentiated specimens (51.18). None of these correlations were significant (P=0.454>0.05). CD4 +/ CD8 ratio was higher in low-grade specimens (180.28) (P=0.017<0.05). No differences between CD4 +, CD8 +and CD4 +/ CD8 ratio between poorly- differentiated and moderately- differentiated groups ROC P value (0.370, 0.248, 0.126) respectively. there is a difference between CD4 +, CD4 +/ CD8ratio between poorly- differentiated and well- differentiated groups ROC P value (0.022, 0.341, 0.012) Sensitivity (0.857, 0.882), specificity (0.706, 0.857) respectively. and no differences between CD8 + poorly- differentiated and well- differentiated groups ROC P value (0.341). there is a difference between CD4 + between moderately - differentiated and well- differentiated groups ROC P value (0.038) Sensitivity (0.368), specificity (0,765). No significant correlation was obtained with clinicopathologic findings of OSCC.
CD4 + and CD4 +/ CD8 + ratio are independent prognostic factor in OSCC.</description><identifier>ISSN: 2476-762X</identifier><identifier>ISSN: 1513-7368</identifier><identifier>EISSN: 2476-762X</identifier><identifier>DOI: 10.31557/APJCP.2022.23.12.4177</identifier><identifier>PMID: 36580000</identifier><language>eng</language><publisher>Thailand: West Asia Organization for Cancer Prevention</publisher><subject>Carcinoma, Squamous Cell - pathology ; CD8-Positive T-Lymphocytes - pathology ; Head and Neck Neoplasms - pathology ; Humans ; Lymphocytes, Tumor-Infiltrating - pathology ; Mouth Neoplasms - pathology ; Prognosis ; Squamous Cell Carcinoma of Head and Neck - pathology</subject><ispartof>Asian Pacific Journal of Cancer Prevention, 2022-12, Vol.23 (12), p.4177-4183</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3297-c80725b76e24d3ee9b1fecbd4ca50e5607faf18631cd6ab2e860107a3ccf8773</citedby><orcidid>0000-0001-5061-2097</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9971484/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9971484/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,27926,27927,53793,53795</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36580000$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wahbi, Hanan Salman</creatorcontrib><creatorcontrib>Manadili, Ahmad</creatorcontrib><title>Immunoexpression of Tumor Infiltrating Lymphocytes(TILS) CD4 + and CD8 + in Oral Squamous Cell Carcinoma (OSCC) in Correlations with Clinicopathological Characteristics and Prognosis</title><title>Asian Pacific Journal of Cancer Prevention</title><addtitle>Asian Pac J Cancer Prev</addtitle><description>This study aimed to analyze CD4 +and CD8 + TILs in oral squamous cell carcinoma (OSCC) and to correlate it with histologic grade of malignancy and clinicopathologic data.
The sample was composed of 43 archived specimens. Clinical features and histological grade of malignancy were obtained. The infiltrating intensity of CD4 +, CD8 positive cells were assessed by immunohistochemistry. One-way ANOVA was used to study the association between CD4 +, CD8 + and the grade of OSCC. The cut-off values of the proposed diagnostic indices were received from calculating the coordinates of the receiver operating characteristic (ROC) curve. For clinicopathologic data Independent-Samples T test, Pearson Correlation Coefficient, Correlation Coefficient were used clinicopathologic characteristics.
CD4 +and CD8 + were observed in all specimens. CD4 + were more frequent in poorly differentiated specimens (74.14) (P= 0.021<0.05). CD8 + were more frequent in well- differentiated specimens (51.18). None of these correlations were significant (P=0.454>0.05). CD4 +/ CD8 ratio was higher in low-grade specimens (180.28) (P=0.017<0.05). No differences between CD4 +, CD8 +and CD4 +/ CD8 ratio between poorly- differentiated and moderately- differentiated groups ROC P value (0.370, 0.248, 0.126) respectively. there is a difference between CD4 +, CD4 +/ CD8ratio between poorly- differentiated and well- differentiated groups ROC P value (0.022, 0.341, 0.012) Sensitivity (0.857, 0.882), specificity (0.706, 0.857) respectively. and no differences between CD8 + poorly- differentiated and well- differentiated groups ROC P value (0.341). there is a difference between CD4 + between moderately - differentiated and well- differentiated groups ROC P value (0.038) Sensitivity (0.368), specificity (0,765). No significant correlation was obtained with clinicopathologic findings of OSCC.
CD4 + and CD4 +/ CD8 + ratio are independent prognostic factor in OSCC.</description><subject>Carcinoma, Squamous Cell - pathology</subject><subject>CD8-Positive T-Lymphocytes - pathology</subject><subject>Head and Neck Neoplasms - pathology</subject><subject>Humans</subject><subject>Lymphocytes, Tumor-Infiltrating - pathology</subject><subject>Mouth Neoplasms - pathology</subject><subject>Prognosis</subject><subject>Squamous Cell Carcinoma of Head and Neck - pathology</subject><issn>2476-762X</issn><issn>1513-7368</issn><issn>2476-762X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkd1q2zAYhsXoWLuut1B02DLi6ceWnJNC0f4yAgkkBz0TsizHKrLkSna33Niub06ylU4nekF6nw--B4BrjDKKi4J_ul__EOuMIEIyQjNMshxz_gZckJyzGWfk4exVPgfvU3pEKC9KXrwD55QVJZrOBfi96LrRB_OrjyYlGzwMDdyOXYhw4RvrhqgG63dwue_6Nuj9YNLNdrHc3ELxOYcfofL1lMopWQ9XUTm4eRpVF8YEhXEOChW19aFT8Ga1EeL28E2EGI2buMEn-NMOLRTOeqtDr4Y2uLCzeuKIVkWlBxNtGqxOx0nrGHY-JJs-gLeNcslc_b0vwfbrl634Pluuvi3E_XKmKZnzmS4RJ0XFmSF5TY2ZV7gxuqpzrQpkCoZ4oxpcMop1zVRFTMkQRlxRrZuSc3oJ7k7Yfqw6U2vjp3042UfbqbiXQVn5_4u3rdyFZzmfc5yX-QRgJ4COIaVompcuRvIoUh5FyoNISajERB5ETsXr15Nfav_M0T9yqZ5b</recordid><startdate>20221201</startdate><enddate>20221201</enddate><creator>Wahbi, Hanan Salman</creator><creator>Manadili, Ahmad</creator><general>West Asia Organization for Cancer Prevention</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5061-2097</orcidid></search><sort><creationdate>20221201</creationdate><title>Immunoexpression of Tumor Infiltrating Lymphocytes(TILS) CD4 + and CD8 + in Oral Squamous Cell Carcinoma (OSCC) in Correlations with Clinicopathological Characteristics and Prognosis</title><author>Wahbi, Hanan Salman ; Manadili, Ahmad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3297-c80725b76e24d3ee9b1fecbd4ca50e5607faf18631cd6ab2e860107a3ccf8773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Carcinoma, Squamous Cell - pathology</topic><topic>CD8-Positive T-Lymphocytes - pathology</topic><topic>Head and Neck Neoplasms - pathology</topic><topic>Humans</topic><topic>Lymphocytes, Tumor-Infiltrating - pathology</topic><topic>Mouth Neoplasms - pathology</topic><topic>Prognosis</topic><topic>Squamous Cell Carcinoma of Head and Neck - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wahbi, Hanan Salman</creatorcontrib><creatorcontrib>Manadili, Ahmad</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Asian Pacific Journal of Cancer Prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wahbi, Hanan Salman</au><au>Manadili, Ahmad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunoexpression of Tumor Infiltrating Lymphocytes(TILS) CD4 + and CD8 + in Oral Squamous Cell Carcinoma (OSCC) in Correlations with Clinicopathological Characteristics and Prognosis</atitle><jtitle>Asian Pacific Journal of Cancer Prevention</jtitle><addtitle>Asian Pac J Cancer Prev</addtitle><date>2022-12-01</date><risdate>2022</risdate><volume>23</volume><issue>12</issue><spage>4177</spage><epage>4183</epage><pages>4177-4183</pages><issn>2476-762X</issn><issn>1513-7368</issn><eissn>2476-762X</eissn><abstract>This study aimed to analyze CD4 +and CD8 + TILs in oral squamous cell carcinoma (OSCC) and to correlate it with histologic grade of malignancy and clinicopathologic data.
The sample was composed of 43 archived specimens. Clinical features and histological grade of malignancy were obtained. The infiltrating intensity of CD4 +, CD8 positive cells were assessed by immunohistochemistry. One-way ANOVA was used to study the association between CD4 +, CD8 + and the grade of OSCC. The cut-off values of the proposed diagnostic indices were received from calculating the coordinates of the receiver operating characteristic (ROC) curve. For clinicopathologic data Independent-Samples T test, Pearson Correlation Coefficient, Correlation Coefficient were used clinicopathologic characteristics.
CD4 +and CD8 + were observed in all specimens. CD4 + were more frequent in poorly differentiated specimens (74.14) (P= 0.021<0.05). CD8 + were more frequent in well- differentiated specimens (51.18). None of these correlations were significant (P=0.454>0.05). CD4 +/ CD8 ratio was higher in low-grade specimens (180.28) (P=0.017<0.05). No differences between CD4 +, CD8 +and CD4 +/ CD8 ratio between poorly- differentiated and moderately- differentiated groups ROC P value (0.370, 0.248, 0.126) respectively. there is a difference between CD4 +, CD4 +/ CD8ratio between poorly- differentiated and well- differentiated groups ROC P value (0.022, 0.341, 0.012) Sensitivity (0.857, 0.882), specificity (0.706, 0.857) respectively. and no differences between CD8 + poorly- differentiated and well- differentiated groups ROC P value (0.341). there is a difference between CD4 + between moderately - differentiated and well- differentiated groups ROC P value (0.038) Sensitivity (0.368), specificity (0,765). No significant correlation was obtained with clinicopathologic findings of OSCC.
CD4 + and CD4 +/ CD8 + ratio are independent prognostic factor in OSCC.</abstract><cop>Thailand</cop><pub>West Asia Organization for Cancer Prevention</pub><pmid>36580000</pmid><doi>10.31557/APJCP.2022.23.12.4177</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-5061-2097</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free E- Journals |
| subjects | Carcinoma, Squamous Cell - pathology CD8-Positive T-Lymphocytes - pathology Head and Neck Neoplasms - pathology Humans Lymphocytes, Tumor-Infiltrating - pathology Mouth Neoplasms - pathology Prognosis Squamous Cell Carcinoma of Head and Neck - pathology |
| title | Immunoexpression of Tumor Infiltrating Lymphocytes(TILS) CD4 + and CD8 + in Oral Squamous Cell Carcinoma (OSCC) in Correlations with Clinicopathological Characteristics and Prognosis |
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