Relapsing Polychondritis and Aseptic Meningoencephalitis
We herein report a 49-year-old Japanese man with relapsing polychondritis (RP) and aseptic meningoencephalitis. Four years ago, the patient was diagnosed with RP. Prednisolone (PSL) was started at 30 mg/day, and the symptoms promptly disappeared. However, cognitive impairment gradually appeared from...
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| Veröffentlicht in: | Internal Medicine 2023/02/01, Vol.62(3), pp.481-486 |
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| container_title | Internal Medicine |
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| creator | Yokota, Kazuhiro Tachibana, Hideyuki Miyake, Akifumi Yamamoto, Toshimasa Mimura, Toshihide |
| description | We herein report a 49-year-old Japanese man with relapsing polychondritis (RP) and aseptic meningoencephalitis. Four years ago, the patient was diagnosed with RP. Prednisolone (PSL) was started at 30 mg/day, and the symptoms promptly disappeared. However, cognitive impairment gradually appeared from six months before hospitalization. Methylprednisolone pulse therapy was immediately initiated, followed by administration of PSL at 1 mg/kg/day. Intravenous cyclophosphamide was combined with PSL. After treatment, the patient's cognitive impairment clearly improved. In conclusion, RP rarely causes aseptic meningoencephalitis, highlighting the need for prompt and aggressive immunosuppressive therapy. |
| doi_str_mv | 10.2169/internalmedicine.9411-22 |
| format | Article |
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Four years ago, the patient was diagnosed with RP. Prednisolone (PSL) was started at 30 mg/day, and the symptoms promptly disappeared. However, cognitive impairment gradually appeared from six months before hospitalization. Methylprednisolone pulse therapy was immediately initiated, followed by administration of PSL at 1 mg/kg/day. Intravenous cyclophosphamide was combined with PSL. After treatment, the patient's cognitive impairment clearly improved. In conclusion, RP rarely causes aseptic meningoencephalitis, highlighting the need for prompt and aggressive immunosuppressive therapy.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.9411-22</identifier><identifier>PMID: 35831110</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>aseptic meningoencephalitis ; Case Report ; Cognitive ability ; Cyclophosphamide ; Cyclophosphamide - therapeutic use ; glucocorticoids ; Humans ; immunosuppressants ; Immunosuppression Therapy - adverse effects ; Immunosuppressive agents ; interleukin-6 ; Internal medicine ; Male ; Meningoencephalitis ; Meningoencephalitis - complications ; Meningoencephalitis - diagnosis ; Meningoencephalitis - drug therapy ; Methylprednisolone ; Middle Aged ; Polychondritis ; Polychondritis, Relapsing - complications ; Polychondritis, Relapsing - diagnosis ; Polychondritis, Relapsing - drug therapy ; Prednisolone ; Prednisolone - therapeutic use ; relapsing polychondritis</subject><ispartof>Internal Medicine, 2023/02/01, Vol.62(3), pp.481-486</ispartof><rights>2023 by The Japanese Society of Internal Medicine</rights><rights>Copyright Japan Science and Technology Agency 2023</rights><rights>Copyright © 2023 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c666t-efe1a2da48c147a21e22aebf87f88d8145468d79978ff54ed0473593eef3adab3</citedby><cites>FETCH-LOGICAL-c666t-efe1a2da48c147a21e22aebf87f88d8145468d79978ff54ed0473593eef3adab3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9970797/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9970797/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,1883,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35831110$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yokota, Kazuhiro</creatorcontrib><creatorcontrib>Tachibana, Hideyuki</creatorcontrib><creatorcontrib>Miyake, Akifumi</creatorcontrib><creatorcontrib>Yamamoto, Toshimasa</creatorcontrib><creatorcontrib>Mimura, Toshihide</creatorcontrib><title>Relapsing Polychondritis and Aseptic Meningoencephalitis</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>We herein report a 49-year-old Japanese man with relapsing polychondritis (RP) and aseptic meningoencephalitis. Four years ago, the patient was diagnosed with RP. Prednisolone (PSL) was started at 30 mg/day, and the symptoms promptly disappeared. However, cognitive impairment gradually appeared from six months before hospitalization. Methylprednisolone pulse therapy was immediately initiated, followed by administration of PSL at 1 mg/kg/day. Intravenous cyclophosphamide was combined with PSL. After treatment, the patient's cognitive impairment clearly improved. In conclusion, RP rarely causes aseptic meningoencephalitis, highlighting the need for prompt and aggressive immunosuppressive therapy.</description><subject>aseptic meningoencephalitis</subject><subject>Case Report</subject><subject>Cognitive ability</subject><subject>Cyclophosphamide</subject><subject>Cyclophosphamide - therapeutic use</subject><subject>glucocorticoids</subject><subject>Humans</subject><subject>immunosuppressants</subject><subject>Immunosuppression Therapy - adverse effects</subject><subject>Immunosuppressive agents</subject><subject>interleukin-6</subject><subject>Internal medicine</subject><subject>Male</subject><subject>Meningoencephalitis</subject><subject>Meningoencephalitis - complications</subject><subject>Meningoencephalitis - diagnosis</subject><subject>Meningoencephalitis - drug therapy</subject><subject>Methylprednisolone</subject><subject>Middle Aged</subject><subject>Polychondritis</subject><subject>Polychondritis, Relapsing - complications</subject><subject>Polychondritis, Relapsing - diagnosis</subject><subject>Polychondritis, Relapsing - drug therapy</subject><subject>Prednisolone</subject><subject>Prednisolone - therapeutic use</subject><subject>relapsing polychondritis</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkcmOEzEQhi0EYsLAK6CWuHDpwVt7uSCNRsMiDYsQnK2Kuzpx5Lgbu4M0b49bCREMl6pDffXX8hPSMHrFmbJvQpoxJ4h77IMPCa-sZKzl_BFZMSFtq7noHpMVtcy0vIYL8qyUHaXCaMufkgvRGcEYoytivmGEqYS0ab6O8d5vx9TnMIfSQOqb64LTHHzzCVMlRkwepy3Epf6cPBkgFnxxypfkx7vb7zcf2rsv7z_eXN-1Xik1tzggA96DNJ5JDZwh54DrwejBmN4w2Ullem2tNsPQSeyp1KKzAnEQ0MNaXJK3R93psK7nekxzhuimHPaQ790Iwf1bSWHrNuMvVyWptroKvD4J5PHnAcvs9qF4jBESjofiuDJW6bpIV9FXD9DdeFj-XCmtlZAdZaJS5kj5PJaScTgvw6hb7HEP7XGLPY7z2vry72POjX_8qMDnI7ArM2zwDECuNkT8X1lxJ5ZwmnAG_RaywyR-A_pNr4A</recordid><startdate>20230201</startdate><enddate>20230201</enddate><creator>Yokota, Kazuhiro</creator><creator>Tachibana, Hideyuki</creator><creator>Miyake, Akifumi</creator><creator>Yamamoto, Toshimasa</creator><creator>Mimura, Toshihide</creator><general>The Japanese Society of Internal Medicine</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20230201</creationdate><title>Relapsing Polychondritis and Aseptic Meningoencephalitis</title><author>Yokota, Kazuhiro ; Tachibana, Hideyuki ; Miyake, Akifumi ; Yamamoto, Toshimasa ; Mimura, Toshihide</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c666t-efe1a2da48c147a21e22aebf87f88d8145468d79978ff54ed0473593eef3adab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>aseptic meningoencephalitis</topic><topic>Case Report</topic><topic>Cognitive ability</topic><topic>Cyclophosphamide</topic><topic>Cyclophosphamide - therapeutic use</topic><topic>glucocorticoids</topic><topic>Humans</topic><topic>immunosuppressants</topic><topic>Immunosuppression Therapy - adverse effects</topic><topic>Immunosuppressive agents</topic><topic>interleukin-6</topic><topic>Internal medicine</topic><topic>Male</topic><topic>Meningoencephalitis</topic><topic>Meningoencephalitis - complications</topic><topic>Meningoencephalitis - diagnosis</topic><topic>Meningoencephalitis - drug therapy</topic><topic>Methylprednisolone</topic><topic>Middle Aged</topic><topic>Polychondritis</topic><topic>Polychondritis, Relapsing - complications</topic><topic>Polychondritis, Relapsing - diagnosis</topic><topic>Polychondritis, Relapsing - drug therapy</topic><topic>Prednisolone</topic><topic>Prednisolone - therapeutic use</topic><topic>relapsing polychondritis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yokota, Kazuhiro</creatorcontrib><creatorcontrib>Tachibana, Hideyuki</creatorcontrib><creatorcontrib>Miyake, Akifumi</creatorcontrib><creatorcontrib>Yamamoto, Toshimasa</creatorcontrib><creatorcontrib>Mimura, Toshihide</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yokota, Kazuhiro</au><au>Tachibana, Hideyuki</au><au>Miyake, Akifumi</au><au>Yamamoto, Toshimasa</au><au>Mimura, Toshihide</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relapsing Polychondritis and Aseptic Meningoencephalitis</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2023-02-01</date><risdate>2023</risdate><volume>62</volume><issue>3</issue><spage>481</spage><epage>486</epage><pages>481-486</pages><artnum>9411-22</artnum><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>We herein report a 49-year-old Japanese man with relapsing polychondritis (RP) and aseptic meningoencephalitis. Four years ago, the patient was diagnosed with RP. Prednisolone (PSL) was started at 30 mg/day, and the symptoms promptly disappeared. However, cognitive impairment gradually appeared from six months before hospitalization. Methylprednisolone pulse therapy was immediately initiated, followed by administration of PSL at 1 mg/kg/day. Intravenous cyclophosphamide was combined with PSL. After treatment, the patient's cognitive impairment clearly improved. In conclusion, RP rarely causes aseptic meningoencephalitis, highlighting the need for prompt and aggressive immunosuppressive therapy.</abstract><cop>Japan</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>35831110</pmid><doi>10.2169/internalmedicine.9411-22</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | aseptic meningoencephalitis Case Report Cognitive ability Cyclophosphamide Cyclophosphamide - therapeutic use glucocorticoids Humans immunosuppressants Immunosuppression Therapy - adverse effects Immunosuppressive agents interleukin-6 Internal medicine Male Meningoencephalitis Meningoencephalitis - complications Meningoencephalitis - diagnosis Meningoencephalitis - drug therapy Methylprednisolone Middle Aged Polychondritis Polychondritis, Relapsing - complications Polychondritis, Relapsing - diagnosis Polychondritis, Relapsing - drug therapy Prednisolone Prednisolone - therapeutic use relapsing polychondritis |
| title | Relapsing Polychondritis and Aseptic Meningoencephalitis |
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