High-fat/high-sucrose diet worsens metabolic outcomes and widespread hypersensitivity following early-life stress exposure in female mice

Exposure to stress early in life has been associated with adult-onset comorbidities such as chronic pain, metabolic dysregulation, obesity, and inactivity. We have established an early-life stress model using neonatal maternal separation (NMS) in mice, which displays evidence of increased body weigh...

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Veröffentlicht in:	American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2023-03, Vol.324 (3), p.R353-R367
Hauptverfasser:	Frick, Jenna M, Eller, Olivia C, Foright, Rebecca M, Levasseur, Brittni M, Yang, Xiaofang, Wang, Ruipeng, Winter, Michelle K, O'Neil, Maura F, Morris, E Matthew, Thyfault, John P, Christianson, Julie A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue Animals Body Weight Calorimetry Chronic pain Comorbidity Diet Diet, High-Fat - adverse effects Dietary Sucrose - adverse effects Energy expenditure Exposure Fatty liver Female Females Food intake Glucocorticoids Glucose tolerance High fat diet Hyperinsulinemia Hypersensitivity Hypothalamic-pituitary-adrenal axis Hypothalamo-Hypophyseal System - metabolism Hypothalamus Inflammation Maternal Deprivation Metabolism Mice Mice, Inbred C57BL Neonates Obesity Obesity - etiology Obesity - metabolism Pain Pain perception Phosphorylation Pituitary Pituitary-Adrenal System - metabolism Steatosis Stress, Psychological Sucrose Triglycerides
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