Factors Related to Plasma Homocysteine Concentration in Young Adults: A Retrospective Study Based on Checkup Populations
The distribution profile of plasma homocysteine (Hcy) in young adults and its related factors are not well understood. We performed a generalized estimating equations (GEE) analysis for plasma-Hcy-correlated factors in 2436 young adults, aged 20-39 years, from a health checkup population. We observe...
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| Veröffentlicht in: | Journal of clinical medicine 2023-02, Vol.12 (4), p.1656 |
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| creator | Li, Zhihua Zhao, Jing Hou, Chengbei Sun, Fei Dong, Jing Guo, Yansu Chu, Xi |
| description | The distribution profile of plasma homocysteine (Hcy) in young adults and its related factors are not well understood. We performed a generalized estimating equations (GEE) analysis for plasma-Hcy-correlated factors in 2436 young adults, aged 20-39 years, from a health checkup population. We observed that the mean Hcy concentration in males (16.7 ± 10.3 μmol/L) was significantly higher than that in females (10.3 ± 4.0 μmol/L), and hyperhomocysteinemia (HHcy) prevalence in males was 5.37 times than that in females (33.3% vs. 6.2%). A GEE analysis stratified by sex indicated that age (B = -0.398,
< 0.001) and LDL-C (B = -1.602,
= 0.043) were negatively correlated, while BMI (B = 0.400,
= 0.042) was positively correlated, with the Hcy level in young males. ALT (B = -0.021,
= 0.033), LDL-C (B = -1.198,
< 0.001) and Glu (B = -0.446,
= 0.006) were negatively correlated, while AST (B = 0.022,
= 0.048), CREA (B = 0.035,
< 0.001), UA (B = 0.004,
= 0.003) and TG (B = 1.042,
< 0.001) were positively correlated, with the Hcy level in young females. These results suggest that young males have a significantly higher plasma Hcy level and HHcy prevalence than young females; therefore, more attention should be paid to the reason for and effect of the higher HHcy prevalence in young males. |
| doi_str_mv | 10.3390/jcm12041656 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9967549</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A750334966</galeid><sourcerecordid>A750334966</sourcerecordid><originalsourceid>FETCH-LOGICAL-c434t-8a2c627c7f66c410179c8b4cd3444f1b4aad54fc0f68dfbf1646e302fe27bd363</originalsourceid><addsrcrecordid>eNptks9vFCEUx4nR2Gbtybsh8WJitoWBgRkPJuvG_kia2LR68EQY5rFlnYFxYBr3v5ft1ro1woEX-LwvvC8PodeUHDNWk5O16WlBOBWleIYOCyLlnLCKPd-LD9BRjGuSR1XxgsqX6ICJiglak0P061SbFMaIr6HTCVqcAr7qdOw1Pg99MJuYwHnAy-AN-DTq5ILHzuPvYfIrvGinLsUPeJHz0xjiACa5O8A3aWo3-JOOWTHzy1swP6YBX4Vh6u4l4iv0wuouwtHDOkPfTj9_XZ7PL7-cXSwXl3PDGU_zShdGFNJIK4ThlFBZm6rhpmWcc0sbrnVbcmuIFVVrG0sFF8BIYaGQTcsEm6GPO91hanpod0V0ahhdr8eNCtqppyfe3apVuFN1LWTJ6yzw7kFgDD8niEn1LhroOu0hTFEVssrOFmV2eobe_oOuwzT6XF6mZF2WPHv-l1rpDpTzNuR7zVZULWRJGOO12L77-D9Uni30zgQP1uX9Jwnvdwkm_0McwT7WSIna9ora65VMv9m35ZH90xnsN06FuhY</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2779554190</pqid></control><display><type>article</type><title>Factors Related to Plasma Homocysteine Concentration in Young Adults: A Retrospective Study Based on Checkup Populations</title><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Li, Zhihua ; Zhao, Jing ; Hou, Chengbei ; Sun, Fei ; Dong, Jing ; Guo, Yansu ; Chu, Xi</creator><creatorcontrib>Li, Zhihua ; Zhao, Jing ; Hou, Chengbei ; Sun, Fei ; Dong, Jing ; Guo, Yansu ; Chu, Xi</creatorcontrib><description>The distribution profile of plasma homocysteine (Hcy) in young adults and its related factors are not well understood. We performed a generalized estimating equations (GEE) analysis for plasma-Hcy-correlated factors in 2436 young adults, aged 20-39 years, from a health checkup population. We observed that the mean Hcy concentration in males (16.7 ± 10.3 μmol/L) was significantly higher than that in females (10.3 ± 4.0 μmol/L), and hyperhomocysteinemia (HHcy) prevalence in males was 5.37 times than that in females (33.3% vs. 6.2%). A GEE analysis stratified by sex indicated that age (B = -0.398,
< 0.001) and LDL-C (B = -1.602,
= 0.043) were negatively correlated, while BMI (B = 0.400,
= 0.042) was positively correlated, with the Hcy level in young males. ALT (B = -0.021,
= 0.033), LDL-C (B = -1.198,
< 0.001) and Glu (B = -0.446,
= 0.006) were negatively correlated, while AST (B = 0.022,
= 0.048), CREA (B = 0.035,
< 0.001), UA (B = 0.004,
= 0.003) and TG (B = 1.042,
< 0.001) were positively correlated, with the Hcy level in young females. These results suggest that young males have a significantly higher plasma Hcy level and HHcy prevalence than young females; therefore, more attention should be paid to the reason for and effect of the higher HHcy prevalence in young males.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm12041656</identifier><identifier>PMID: 36836190</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Age groups ; Blood ; Blood plasma ; Body mass index ; Brief Report ; Cardiovascular disease ; Cholesterol ; Clinical medicine ; Composition ; Coronary vessels ; Correlation analysis ; DNA methylation ; Health aspects ; High density lipoprotein ; Homocysteine ; Hospitals ; Males ; Measurement ; Medical examination ; Metabolism ; Plasma ; Risk factors ; Young adults</subject><ispartof>Journal of clinical medicine, 2023-02, Vol.12 (4), p.1656</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c434t-8a2c627c7f66c410179c8b4cd3444f1b4aad54fc0f68dfbf1646e302fe27bd363</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967549/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967549/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36836190$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Zhihua</creatorcontrib><creatorcontrib>Zhao, Jing</creatorcontrib><creatorcontrib>Hou, Chengbei</creatorcontrib><creatorcontrib>Sun, Fei</creatorcontrib><creatorcontrib>Dong, Jing</creatorcontrib><creatorcontrib>Guo, Yansu</creatorcontrib><creatorcontrib>Chu, Xi</creatorcontrib><title>Factors Related to Plasma Homocysteine Concentration in Young Adults: A Retrospective Study Based on Checkup Populations</title><title>Journal of clinical medicine</title><addtitle>J Clin Med</addtitle><description>The distribution profile of plasma homocysteine (Hcy) in young adults and its related factors are not well understood. We performed a generalized estimating equations (GEE) analysis for plasma-Hcy-correlated factors in 2436 young adults, aged 20-39 years, from a health checkup population. We observed that the mean Hcy concentration in males (16.7 ± 10.3 μmol/L) was significantly higher than that in females (10.3 ± 4.0 μmol/L), and hyperhomocysteinemia (HHcy) prevalence in males was 5.37 times than that in females (33.3% vs. 6.2%). A GEE analysis stratified by sex indicated that age (B = -0.398,
< 0.001) and LDL-C (B = -1.602,
= 0.043) were negatively correlated, while BMI (B = 0.400,
= 0.042) was positively correlated, with the Hcy level in young males. ALT (B = -0.021,
= 0.033), LDL-C (B = -1.198,
< 0.001) and Glu (B = -0.446,
= 0.006) were negatively correlated, while AST (B = 0.022,
= 0.048), CREA (B = 0.035,
< 0.001), UA (B = 0.004,
= 0.003) and TG (B = 1.042,
< 0.001) were positively correlated, with the Hcy level in young females. These results suggest that young males have a significantly higher plasma Hcy level and HHcy prevalence than young females; therefore, more attention should be paid to the reason for and effect of the higher HHcy prevalence in young males.</description><subject>Age groups</subject><subject>Blood</subject><subject>Blood plasma</subject><subject>Body mass index</subject><subject>Brief Report</subject><subject>Cardiovascular disease</subject><subject>Cholesterol</subject><subject>Clinical medicine</subject><subject>Composition</subject><subject>Coronary vessels</subject><subject>Correlation analysis</subject><subject>DNA methylation</subject><subject>Health aspects</subject><subject>High density lipoprotein</subject><subject>Homocysteine</subject><subject>Hospitals</subject><subject>Males</subject><subject>Measurement</subject><subject>Medical examination</subject><subject>Metabolism</subject><subject>Plasma</subject><subject>Risk factors</subject><subject>Young adults</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNptks9vFCEUx4nR2Gbtybsh8WJitoWBgRkPJuvG_kia2LR68EQY5rFlnYFxYBr3v5ft1ro1woEX-LwvvC8PodeUHDNWk5O16WlBOBWleIYOCyLlnLCKPd-LD9BRjGuSR1XxgsqX6ICJiglak0P061SbFMaIr6HTCVqcAr7qdOw1Pg99MJuYwHnAy-AN-DTq5ILHzuPvYfIrvGinLsUPeJHz0xjiACa5O8A3aWo3-JOOWTHzy1swP6YBX4Vh6u4l4iv0wuouwtHDOkPfTj9_XZ7PL7-cXSwXl3PDGU_zShdGFNJIK4ThlFBZm6rhpmWcc0sbrnVbcmuIFVVrG0sFF8BIYaGQTcsEm6GPO91hanpod0V0ahhdr8eNCtqppyfe3apVuFN1LWTJ6yzw7kFgDD8niEn1LhroOu0hTFEVssrOFmV2eobe_oOuwzT6XF6mZF2WPHv-l1rpDpTzNuR7zVZULWRJGOO12L77-D9Uni30zgQP1uX9Jwnvdwkm_0McwT7WSIna9ora65VMv9m35ZH90xnsN06FuhY</recordid><startdate>20230219</startdate><enddate>20230219</enddate><creator>Li, Zhihua</creator><creator>Zhao, Jing</creator><creator>Hou, Chengbei</creator><creator>Sun, Fei</creator><creator>Dong, Jing</creator><creator>Guo, Yansu</creator><creator>Chu, Xi</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20230219</creationdate><title>Factors Related to Plasma Homocysteine Concentration in Young Adults: A Retrospective Study Based on Checkup Populations</title><author>Li, Zhihua ; Zhao, Jing ; Hou, Chengbei ; Sun, Fei ; Dong, Jing ; Guo, Yansu ; Chu, Xi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-8a2c627c7f66c410179c8b4cd3444f1b4aad54fc0f68dfbf1646e302fe27bd363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Age groups</topic><topic>Blood</topic><topic>Blood plasma</topic><topic>Body mass index</topic><topic>Brief Report</topic><topic>Cardiovascular disease</topic><topic>Cholesterol</topic><topic>Clinical medicine</topic><topic>Composition</topic><topic>Coronary vessels</topic><topic>Correlation analysis</topic><topic>DNA methylation</topic><topic>Health aspects</topic><topic>High density lipoprotein</topic><topic>Homocysteine</topic><topic>Hospitals</topic><topic>Males</topic><topic>Measurement</topic><topic>Medical examination</topic><topic>Metabolism</topic><topic>Plasma</topic><topic>Risk factors</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Zhihua</creatorcontrib><creatorcontrib>Zhao, Jing</creatorcontrib><creatorcontrib>Hou, Chengbei</creatorcontrib><creatorcontrib>Sun, Fei</creatorcontrib><creatorcontrib>Dong, Jing</creatorcontrib><creatorcontrib>Guo, Yansu</creatorcontrib><creatorcontrib>Chu, Xi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Zhihua</au><au>Zhao, Jing</au><au>Hou, Chengbei</au><au>Sun, Fei</au><au>Dong, Jing</au><au>Guo, Yansu</au><au>Chu, Xi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factors Related to Plasma Homocysteine Concentration in Young Adults: A Retrospective Study Based on Checkup Populations</atitle><jtitle>Journal of clinical medicine</jtitle><addtitle>J Clin Med</addtitle><date>2023-02-19</date><risdate>2023</risdate><volume>12</volume><issue>4</issue><spage>1656</spage><pages>1656-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>The distribution profile of plasma homocysteine (Hcy) in young adults and its related factors are not well understood. We performed a generalized estimating equations (GEE) analysis for plasma-Hcy-correlated factors in 2436 young adults, aged 20-39 years, from a health checkup population. We observed that the mean Hcy concentration in males (16.7 ± 10.3 μmol/L) was significantly higher than that in females (10.3 ± 4.0 μmol/L), and hyperhomocysteinemia (HHcy) prevalence in males was 5.37 times than that in females (33.3% vs. 6.2%). A GEE analysis stratified by sex indicated that age (B = -0.398,
< 0.001) and LDL-C (B = -1.602,
= 0.043) were negatively correlated, while BMI (B = 0.400,
= 0.042) was positively correlated, with the Hcy level in young males. ALT (B = -0.021,
= 0.033), LDL-C (B = -1.198,
< 0.001) and Glu (B = -0.446,
= 0.006) were negatively correlated, while AST (B = 0.022,
= 0.048), CREA (B = 0.035,
< 0.001), UA (B = 0.004,
= 0.003) and TG (B = 1.042,
< 0.001) were positively correlated, with the Hcy level in young females. These results suggest that young males have a significantly higher plasma Hcy level and HHcy prevalence than young females; therefore, more attention should be paid to the reason for and effect of the higher HHcy prevalence in young males.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>36836190</pmid><doi>10.3390/jcm12041656</doi><oa>free_for_read</oa></addata></record> |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Age groups Blood Blood plasma Body mass index Brief Report Cardiovascular disease Cholesterol Clinical medicine Composition Coronary vessels Correlation analysis DNA methylation Health aspects High density lipoprotein Homocysteine Hospitals Males Measurement Medical examination Metabolism Plasma Risk factors Young adults |
| title | Factors Related to Plasma Homocysteine Concentration in Young Adults: A Retrospective Study Based on Checkup Populations |
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